LOCALIZED DUODENAL AMYLOIDOSIS: DIAGNOSTIC CHALLENGE IN A PATIENT WITH NONSPECIFIC GASTROINTESTINAL SYMPTOMS
DOI:
https://doi.org/10.56238/arev7n10-090Keywords:
Duodenal Amyloidosis, Diagnosis, Asymptomatic, Amyloid DepositionAbstract
Introduction: Amyloidosis is a condition characterized by the extracellular deposition of misfolded proteins, which can occur systemically or locally. Isolated gastrointestinal amyloidosis is rare, with the duodenum being one of the least frequently affected sites. Diagnosis is challenging due to the nonspecificity of gastrointestinal symptoms and the endoscopic similarity to benign lesions, such as lipomas. Diagnostic confirmation is performed by biopsy with specific staining and immunohistochemistry. Objective: To demonstrate the importance of histopathological investigation in apparently benign lesions through a rare case of duodenal amyloidosis in an asymptomatic patient. Methods: Based on a case reported at Santa Casa de Misericórdia de Presidente Prudente, information was collected from the medical records to prepare this report. Discussion: Amyloidosis tends to affect multiple body systems, making this case rare. Concomitantly, there was no underlying disease or gastrointestinal symptoms, and the discovery was incidental, through an endoscopy requested due to a history of gastric ulcer. Conclusion: Localized duodenal amyloidosis, despite its rarity, should be considered in the differential diagnosis of duodenal lesions, in addition to demonstrating the need for a high degree of clinical suspicion, especially in at-risk populations, even in asymptomatic patients or those without associated diseases.
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