THERAPEUTIC WINDOW AND NEUROPLASTICITY IN THE MANAGEMENT OF ACUTE STROKE
DOI:
https://doi.org/10.56238/arev8n6-010Keywords:
Stroke, Therapeutic Window, Neuroplasticity, Cerebral Ischemia, Reperfusion, Neurological RehabilitationAbstract
Stroke is one of the leading causes of morbidity, mortality, and functional disability worldwide. In the context of acute stroke, the therapeutic window plays a fundamental role in preserving viable brain tissue, while neuroplasticity is crucial for functional recovery. This study aimed to analyze the relationship between the therapeutic window and neuroplasticity mechanisms in the management of acute stroke. This is an integrative literature review conducted using the PubMed, SciELO, and Virtual Health Library databases, including articles published between 2021 and 2026. The results demonstrate that early interventions, such as intravenous thrombolysis and mechanical thrombectomy, are associated with reduced extent of brain injury and improved functional prognosis. At the same time, the activation of neuroplasticity mechanisms, especially during the subacute period, contributes to cortical reorganization and recovery of neurological functions. It is concluded that intervention within the therapeutic window not only reduces neuronal damage but also enhances neuroplasticity, reinforcing the importance of early and integrated approaches in the care of stroke patients.
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