PHEOCHROMOCYTOMA IN A YOUNG PERSON AS A CAUSE OF SECONDARY HYPERTENSION: A CASE REPORT
DOI:
https://doi.org/10.56238/arev8n2-107Keywords:
Pheochromocytoma, Young, Secondary HypertensionAbstract
Systemic Arterial Hypertension (SAH) is one of the most prevalent chronic non-communicable diseases worldwide, with secondary hypertension being less frequent and generally associated with identifiable clinical causes, such as pheochromocytoma. Pheochromocytoma is a rare neuroendocrine tumor originating from chromaffin cells, characterized by the excessive production of catecholamines, resulting in paroxysmal hypertensive crises and autonomic manifestations. This study describes the case of a young patient treated at a public hospital in Minas Gerais, who began presenting with nausea, vomiting, tachypnea, and extreme tachycardia in October 2021. Initially diagnosed with COVID-19 associated with anaphylaxis, he required hospitalization in an intensive care unit. After discharge, he continued outpatient follow-up with recurrent episodes of tachycardia, hypertension, and sweating, in addition to mild left ventricular hypertrophy on echocardiography and hypertensive peaks that were difficult to control. Despite the use of multiple antihypertensive drugs, the symptoms persisted, prompting further etiological investigation. Diagnostic confirmation was obtained through laboratory tests showing a significant elevation of urinary catecholamines and metanephrines, associated with imaging findings compatible with extraadrenal pheochromocytoma. This case reinforces the importance of clinical suspicion and a systematic diagnostic approach in young patients with resistant hypertension and symptoms suggestive of catecholaminergic discharge, aiming for early diagnosis and appropriate management.
Downloads
References
AL GHORANI, H.; BÖHM, M.; GOTZINGER, F.; MAHFOUD, F. Arterial hypertension - Clinical trials update 2021. Nutrition, Metabolism and Cardiovascular Diseases, v. 32, n. 1, p. 21–31, jan. 2022. DOI: https://doi.org/10.1016/j.numecd.2021.09.007
AZEVEDO, P.; CARVALHO, S.; PINHEIRO, L. Hipertensão secundária: além do diagnóstico. Revista Portuguesa de Medicina Geral e Familiar, v. 41, n. 1, p. 78– 82, 2025. Disponível em: https://rpmgf.pt/ojs/index.php/rpmgf/article/view/13914. Acesso em: 11 jun. 2025. DOI: https://doi.org/10.32385/rpmgf.v41i1.13914
BARBOSA, V. M.; BARROSO, A. T. G.; CASTRO, I. B.; MARINHO, L. L.; SILVA, P. A. Hipertensão arterial sistêmica: abordagem atual, diagnóstico e estratégias terapêuticas. Brazilian Journal of Health Review, Curitiba, v. 8, n.2, p. 01-16, 2025. DOI: https://doi.org/10.34119/bjhrv8n2-368
CASEY, R. T.; HENDRIKS, E.; DEAL, C.; WAGUESPACK, S. G.; WIEGERING, V.; REDLICH, A.; AKKER, S.; PRASAD, R.; FASSNACHT, M.; CLIFTON-BLIGH, R. et al. International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents. Nature Reviews Endocrinology, v. 20, p. 729–748, 2024. DOI: https://doi.org/10.1038/s41574-024-01024-5
CELESTINO, K. A. A.; COSTA, C. S. C.; COSTA, G. S.; IMBROZIO, A. M. T.; MARTINS, C. L.; PIRES, M. K. D.; SANTANA, P. F. Hipertensão arterial resistente: desvendando suas principais causas, potenciais complicações e o papel da atenção primária. Brazilian Journal of Health Review, v. 8, n. 1, 2025. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/76938/53506. Acesso em: 11 jun. 2025. DOI: https://doi.org/10.34119/bjhrv8n1-209
COSTA, T.; LEITÃO, D. C. Hipertensão secundária: abordagem nos cuidados de saúde primários. Revista Portuguesa de Medicina Geral e Familiar, v. 37, n. 6, p. 535-548, 2021. DOI: https://doi.org/10.32385/rpmgf.v37i6.12722
CUSPIDI, C.; GHERBESI, E.; FAGGIANO, A.; SALA, C.; CARUGO, S.; GRASSI, G.; TADIC, M. Targeting left ventricular mechanics in patients with pheochromocytoma/paraganglioma: an updated meta-analysis. American Journal of Hypertension, Oxford, v. 36, n. 6, p. 333–340, 2023. DOI: https://doi.org/10.1093/ajh/hpad006
EISENHOFER, G.; PEITZSCH, M.; BECHMANN, N.; HUEBNER, A. Biochemical diagnosis of catecholamine-producing tumors of childhood: neuroblastoma, pheochromocytoma and paraganglioma. Frontiers in Endocrinology, v. 13, p. 901760, 2022. DOI: https://doi.org/10.3389/fendo.2022.901760
GOPINATHANNAIR, R.; OLSHANSKY, B.; CHUNG, M. K.; GORDON, S.; JOGLAR, J. A.; MARCUS, G. M.; MAR, P. L.; RUSSO, A. M.; SRIVATSA, U. N.; WAN, E. Y.; AMERICAN HEART ASSOCIATION ELECTROCARDIOGRAPHY AND ARRHYTHMIAS COMMITTEE OF THE COUNCIL ON CLINICAL CARDIOLOGY; COUNCIL ON BASIC CARDIOVASCULAR SCIENCES; COUNCIL ON CARDIOVASCULAR AND STROKE NURSING; COUNCIL ON GENOMIC AND PRECISION MEDICINE; COUNCIL ON HYPERTENSION. Cardiac arrhythmias and autonomic dysfunction associated with COVID-19: a scientific statement from the American Heart Association. Circulation, v. 150, n. 21, p. e449-e465, 2024. DOI: https://doi.org/10.1161/CIR.0000000000001290
GUPTA, P. K.; MARWAHA, B. Pheochromocytoma. [Updated 2024 Nov 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2025 Jan-. Disponível em: https://www.ncbi.nlm.nih.gov/books/NBK589700/. Acesso em: 15 nov 2025.
HUANG, R.; LIN, T.; CHEN, M.; LI, X.; GUO, H. Diagnostic performance of magnetic resonance imaging features to differentiate adrenal pheochromocytoma from adrenal tumors with positive biochemical testing results. BMC Medical Imaging, v. 24, n. 1, p. 175, 2024. DOI: https://doi.org/10.1186/s12880-024-01350-0
JAMESON, J. L. Harrison: princípios de medicina interna. 21. ed. Rio de Janeiro: McGraw-Hill, 2022.
KVASNIČKA, J.; ZELINKA, T.; PETRÁK, O.; ROSA, J.; ŠTRAUCH, B.; KRÁTKÁ, Z.; INDRA, T.; MARKVARTOVÁ, A.; WIDIMSKÝ, J., Jr.; HOLAJ, R. Catecholamines induce left ventricular subclinical systolic dysfunction: a speckle-tracking echocardiography study. Cancers, v. 11, n. 3, p. 318, 2019. DOI: https://doi.org/10.3390/cancers11030318
JOCHMANOVA, I.; ABCEDE, A. M. T.; GUERRERO, R. J. S.; MALONG, C. L. P.; WESLEY, R.; HUYNH, T.; GONZALES, M. K.; WOLF, K. I.; JHA, A.; KNUE, M.; PRODANOV, T.; NILUBOL, N.; MERCADO-ASIS, L. B.; STRATAKIS, C. A.; PACAK, K. Clinical characteristics and outcomes of SDHB-related pheochromocytoma and paraganglioma in children and adolescents. Journal of Cancer Research and Clinical Oncology, Berlin, v. 146, n. 4, p. 1051–1063, 2020. DOI: https://doi.org/10.1007/s00432-020-03138-5
KOCH, C.; PAPADOPOULOU-MARKETOU, N.; CHROUSOS, G. P. Overview of endocrine hypertension. [Updated 2020 Feb 4]. In: FEINGOLD, K. R.; AHMED, S. F.; ANAWALT, B. et al. (ed.). Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc., 2000-. Disponível em: https://www.ncbi.nlm.nih.gov/books/NBK278980/. Acesso em: 15 nov 2025.
PEIGER-FLORES, B. M.; SÁNCHEZ-SOSA, J. S. Feocromocitoma: Uma causa incomum de angina. Acta Médica Colombiana, v. 49, n. 1, 2023. DOI: https://doi.org/10.36104/amc.2024.2904
SAAVEDRA, T. J. S.; NATI-CASTILLO, H. A.; VALDERRAMA COMETA, L. A.; RIVERA-MARTÍNEZ, W. A.; ASPRILLA, J.; CASTAÑO-GIRALDO, C. M.; SÁNCHEZ, S. L.; HEREDIA-ESPÍN, M.; ARIAS-INTRIAGO, M.; IZQUIERDO-CONDOY, J. S. Pheochromocytoma: an updated scoping review from clinical presentation to management and treatment. Frontiers in Endocrinology, v. 15, p. 1433582, 2024. DOI: https://doi.org/10.3389/fendo.2024.1433582
YUGAR-TOLEDO, J. C.; MORENO JÚNIOR, H.; GUS, M.; ROSITO, G. B. A.; SCALA, L. C. N.; MUXFELDT, E. S.; ALESSI, A.; BRANDÃO, A. A.; MOREIRA FILHO, O.; FEITOSA, A. D. M.; PASSARELLI JÚNIOR, O.; SOUZA, D. D. S. M.; AMODEO, C.; BARROSO, W. K. S.; GOMES, M. A. M.; PAIVA, A. M. G.; BARBOSA, E. C. D.; MIRANDA, R. D.; VILELA-MARTIN, J. F.; NADRUZ JÚNIOR, W.; RODRIGUES, C. I. S.; DRAGER, L. F.; BORTOLOTTO, L. A.; CONSOLIM-COLOMBO, F. M.; SOUSA, M. G.; BORELLI, F. A. O.; KAISER, S. E.; SALLES, G. F.; AZEVEDO, M. F.; MAGALHÃES, L. B. N. C.; PÓVOA, R. M. D. S.; MALACHIAS, M. V. B.; NOGUEIRA, A. D. R.; JARDIM, P. C. B. V.; JARDIM, T. S. V. Brazilian position statement on resistant hypertension – 2020. Arquivos Brasileiros de Cardiologia, v. 114, n. 3, p. 576-596, 2020.