SÍNDROME DE DRESS E SÍNDROME DE STEVENS-JOHNSON: ASPECTOS CLÍNICOS, FISIOPATOLÓGICOS E TERAPÊUTICOS EM UMA REVISÃO NARRATIVA COMPARATIVA
DOI:
https://doi.org/10.56238/arev7n11-252Palavras-chave:
Síndrome de DRESS, Síndrome de Stevens-Johnson, Reações Cutâneas Graves, Hipersensibilidade Medicamentosa, Revisão NarrativaResumo
A Síndrome de DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) e a Síndrome de Stevens-Johnson (SSJ) são reações cutâneas graves induzidas por fármacos, com risco significativo de morbimortalidade. Ambas compartilham alguns mecanismos imunológicos, mas diferem em sua fisiopatologia, tempo de latência, padrão de acometimento orgânico e prognóstico. Esta revisão narrativa tem como objetivo comparar aspectos clínicos, laboratoriais, fisiopatológicos e terapêuticos dessas síndromes, fornecendo subsídios para diagnóstico diferencial e condutas clínicas adequadas.
Downloads
Referências
1. BRÜGGEN, M. C.; et al. Drug reaction with eosinophilia and systemic symptoms (DRESS): A comprehensive review of clinical features, diagnostic criteria, and management strategies. JAMA Dermatology, v. 160, n. 5, p. 515-523, 2024. Disponível em: https://jamanetwork.com/journals/jamadermatology/fullarticle/2812063.
2. WANG, S.; et al. The systemic treatments for drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. World Allergy Organization Journal, v. 17, n. 1, p. 100066, 2024. Disponível em: https://www.worldallergyorganizationjournal.org/article/S1939-4551(24)00066-8/fulltext.
3. HAMA, N.; et al. Recent progress in Stevens–Johnson syndrome/toxic epidermal necrolysis: Diagnostic criteria, pathogenesis and treatment. British Journal of Dermatology, v. 192, n. 1, p. 9-18, 2024. Disponível em: https://pubmed.ncbi.nlm.nih.gov/39141587/.
4. SHAH, H.; et al. Update on Stevens–Johnson syndrome and toxic epidermal necrolysis. Journal of the European Academy of Dermatology and Venereology, v. 38, n. 5, p. 902-912, 2024. Disponível em: https://link.springer.com/article/10.1007/s40257-024-00889-6.
5. JUSTICE, J.; et al. Updates in the pathogenesis of Stevens–Johnson syndrome and toxic epidermal necrolysis. Journal of Dermatological Science, v. 100, n. 2, p. 67-74, 2025. Disponível em: https://www.sciencedirect.com/science/article/pii/S1323893025000528.
6. OAKLEY, A. M.; et al. Stevens–Johnson syndrome. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2023. Disponível em: https://www.ncbi.nlm.nih.gov/books/NBK459323/.
7. SAITO, Y.; et al. New insights into the diagnosis and management of Stevens–Johnson syndrome and toxic epidermal necrolysis. Journal of Dermatology, v. 52, n. 8, p. 1043-1052, 2023. Disponível em: https://pubmed.ncbi.nlm.nih.gov/37284785/.
8. METTERLE, M.; et al. Pediatric DRESS syndrome: A review of clinical features and management. Frontiers in Medicine, v. 10, p. 1108345, 2023. Disponível em: https://www.frontiersin.org/articles/10.3389/fmed.2023.1108345/full.
9. VERSTEGAN, R. H. J.; et al. First-line therapy in drug reaction with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity syndrome (DIHS). Frontiers in Medicine, v. 10, p. 1138464, 2023. Disponível em: https://www.frontiersin.org/articles/10.3389/fmed.2023.1138464/full.
10. RAJAPPA, M. C.; et al. DRESS syndrome: A comprehensive review of its clinical and systemic complexities. Biomedicine & Pharmacotherapy, v. 18, n. 2, p. 100066, 2025. Disponível em: https://biomedpharmajournal.org/vol18no2/dress-syndrome-a-comprehensive-review-of-its-clinical-and-systemic-complexities
11. CHUENWIPASAKUL, D.; et al. Correlations between histopathologic findings, serum biomarkers, and clinical outcomes in Stevens–Johnson syndrome and toxic epidermal necrolysis. Scientific Reports, v. 13, p. 40812, 2023. Disponível em: https://www.nature.com/articles/s41598-023-40812-3.
12. O’REILLY, P.; et al. Impact of Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) on quality of life and long-term outcomes. British Journal of Dermatology, v. 193, n. 4, p. 662-670, 2025. Disponível em: https://academic.oup.com/bjd/article/193/4/662/8170147.
13. HANSEN, E.; et al. Risk assessment of drugs associated with DRESS syndrome based on publication frequency: A systematic review. Journal of the American Academy of Dermatology, v. 91, n. 5, p. 962-966, 2024. Disponível em: https://pubmed.ncbi.nlm.nih.gov/39002560/.
14. ZHAO, J.; et al. Recent advances in the diagnosis and treatment of drug-induced hypersensitivity syndrome (DIHS)/DRESS. Journal of Dermatological Science, v. 100, n. 2, p. 67-74, 2025. Disponível em: https://www.sciencedirect.com/science/article/pii/S1323893025000462.
15. KROSHINSKY, D.; et al. Drug reaction with eosinophilia and systemic symptoms (DRESS): A serious drug-induced T-cell–mediated condition with marked cutaneous and systemic effects. New England Journal of Medicine, v. 392, n. 9, p. 785-787, 2025. Disponível em: https://www.nejm.org/doi/full/10.1056/NEJMc2500319