MELATONIN AS AN ADJUVANT IN THE CONTROL OF GLYCATED HEMOGLOBIN IN PATIENTS WITH DIABETES AND PERIODONTAL DISEASE

Abstract

Objective: The objective of this narrative review article is to address the possible effectiveness of melatonin as an adjuvant in the control of glycated hemoglobin in patients with diabetes and periodontal disease.

Methodology: This article is a narrative literature review. Therefore, it was necessary to conduct online searches to obtain a set of articles related to the topic addressed in this study. The online searches were conducted in the following online databases: PubMed, Cochrane Library, EMBASE, and Google Scholar. During these searches, to obtain only results related to the present study, the following keywords were used: Melatonin, Salivary, Periodontitis, Glycated Hemoglobin. Furthermore, Boolean terms such as "AND" and "OR" were used in PubMed and Cochrane searches. After conducting the searches, the results were screened, a process divided into three phases: The first phase is the elimination of duplicate articles, eliminating duplicates through the Zotero platform. The second phase was to eliminate articles unrelated to the topic by reading their titles and abstracts. The third and final phase consisted of reading the remaining articles in full, using studies compatible with this narrative review.

Results: Studies have shown that melatonin, either in conjunction with non-surgical periodontal treatment or alone, has a positive effect on glycated hemoglobin levels in diabetic patients with periodontal disease.

Conclusion: A set of studies shows that melatonin is a viable and promising option when used in patients with diabetes and periodontal disease, providing benefits in regulating glycated hemoglobin levels. However, further studies are needed to standardize dosage, duration of use and administration.