SURGICAL MANAGEMENT OF GASTROESOPHAGEAL REFLUX DISEASE (GERD): INDICATIONS AND PREOPERATIVE PROTOCOLS
DOI:
https://doi.org/10.56238/arev8n3-007Keywords:
Gastroesophageal Reflux Disease, Laparoscopic Antireflux Surgery, Fundoplication, Esophageal Manometry, pH-Metry, Preoperative ProtocolAbstract
Gastroesophageal Reflux Disease (GERD) is a prevalent chronic condition. Although clinical treatment with Proton Pump Inhibitors (PPIs) is the initial basis, it is estimated that up to 40% of patients present with refractory symptoms. For this group, surgical management, predominantly performed through Laparoscopic Antireflux Fundoplication (LARS), represents an effective alternative to restore the competence of the esophagogastric junction. However, the success of the intervention depends on a rigorous selection of candidates and a comprehensive preoperative protocol. This protocol requires objective confirmation of GERD and exclusion of differential diagnoses, with Upper Digestive Endoscopy (EGD), High-Resolution Esophageal Manometry (to assess motility and guide the surgical technique), and 24-hour esophageal pH-Impedance monitoring (gold standard for documenting pathological reflux, especially in refractory or extraesophageal cases) being indispensable. LARS provides significant symptomatic relief in appropriately selected patients, reinforcing that the integration of clinical data and functional examinations is the cornerstone for a safe and effective surgical indication.
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References
CHEN, J. W. et al. AGA Clinical Practice Update on the Diagnosis and Management of Extraesophageal Gastroesophageal Reflux Disease: Expert Review. Clinical Gastroenterology and Hepatology, v. 21, n. 6, p. 1414-1421, 2023. DOI: https://doi.org/10.1016/j.cgh.2023.01.040
CUI, N. et al. Laryngopharyngeal reflux disease: Updated examination of mechanisms, pathophysiology, treatment, and association with gastroesophageal reflux disease. World Journal of Gastroenterology, v. 30, n. 16, p. 2209-2219, 2024. DOI: https://doi.org/10.3748/wjg.v30.i16.2209
KASUGAI, K.; OGASAWARA, N. Gastroesophageal Reflux Disease: Pathophysiology and New Treatment Trends. Internal Medicine, v. 63, n. 1, p. 1-10, 2024. DOI: https://doi.org/10.2169/internalmedicine.1551-23
KATZ, P. O. et al. ACG Clinical Guideline: Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease. American Journal of Gastroenterology, v. 117, n. 1, p. 27-56, 2022. DOI: https://doi.org/10.14309/ajg.0000000000001538
UGLIONO, E. et al. Laparoscopic antireflux surgery for refractory gastroesophageal reflux disease: long-term clinical outcomes. Updates in Surgery, v. 75, n. 4, p. 979-986, 2023. DOI: https://doi.org/10.1007/s13304-023-01483-x
WU, G. et al. Unraveling the causality between gastroesophageal reflux disease and increased cancer risk: evidence from the UK Biobank and GWAS consortia. BMC Medicine, v. 22, n. 1, p. 323, 2024. DOI: https://doi.org/10.1186/s12916-024-03526-5
ZHENG, Z. et al. Current Advancement on the Dynamic Mechanism of Gastroesophageal Reflux Disease. International Journal of Biological Sciences, v. 17, n. 15, p. 4154-4164, 2021. DOI: https://doi.org/10.7150/ijbs.65066