POTENTIAL OF THE ESSENTIAL OIL OF ALPINIA ZERUMBET (PERS.) B.L. BURTT & R. M. SM. (COLONIA) AGAINST ALZHEIMER'S DISEASE, THROUGH ANTIOXIDANT AND ANTICHOLINESTERASE ACTIVITY IN VITRO AND IN SILICO STUDIES

Authors

  • Selene M. de Morais Author
  • Felipe W. V. Paulino Author
  • Daniel P. de Oliveira Author
  • Rita de C. A. Pereira Author
  • Wildson Max B. da Silva Author
  • Daniela R. Alves Author
  • Jacilene Silva Author
  • Emmanuel S. Marinho Author

DOI:

https://doi.org/10.56238/arev7n1-153

Keywords:

Cholinergic Hypothesis, Free Radicals, Molecular Docking

Abstract

The plant Alpinia zerumbet, commonly known as "Colônia," is widely utilized in traditional medicine for addressing anxiety and hypertension, both of which are associated with oxidative damage in the brain. This study aimed to explore the antioxidant and anticholinesterase properties of the essential oil extracted from its leaves. Additionally, an in-silico investigation was carried out on several essential oil constituents concerning the acetylcholinesterase enzyme. The GC/MS analysis identified nineteen volatile compounds, mainly monoterpenoids (98.41%), particularly terpinen-4-ol, eucalyptol,

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Published

2025-01-20

Issue

Vol. 7 No. 1 (2025)

Section

Articles

How to Cite

DE MORAIS, Selene M.; PAULINO, Felipe W. V.; DE OLIVEIRA, Daniel P.; PEREIRA, Rita de C. A.; DA SILVA, Wildson Max B.; ALVES, Daniela R.; SILVA, Jacilene; MARINHO, Emmanuel S. POTENTIAL OF THE ESSENTIAL OIL OF ALPINIA ZERUMBET (PERS.) B.L. BURTT & R. M. SM. (COLONIA) AGAINST ALZHEIMER’S DISEASE, THROUGH ANTIOXIDANT AND ANTICHOLINESTERASE ACTIVITY IN VITRO AND IN SILICO STUDIES. ARACÊ , [S. l.], v. 7, n. 1, p. 2516–2534, 2025. DOI: 10.56238/arev7n1-153. Disponível em: https://periodicos.newsciencepubl.com/arace/article/view/2890. Acesso em: 5 feb. 2025.