POLIMORFISMO DOS GENES APO-A E APO-B E O PERFIL LIPÍDICO DE PACIENTES COM COVID-19: UMA REVISÃO INTEGRATIVA
DOI:
https://doi.org/10.56238/arev7n12-058Palavras-chave:
Apolipoproteína B, Apolipoproteína A-1, Obesidade, COVID-19, Polimorfismo GenéticoResumo
Objetivo: analisar a influência dos polimorfismos dos genes APOA e APOB com o perfil lipídico de pacientes com COVID-19. Metodologia: realizou-se a pesquisa nas bases de dados Scholar Google, Biblioteca Virtual em Saúde – BVS, Portal de Periódicos CAPES, e PubMed, utilizando os descritores “Apo-B polymorphism AND SARS-Cov-2 AND COVID-19” e “Apo-A polymorphism AND Covid-19”. Foram selecionados estudos a partir de 2020 e que fossem compatíveis com o objetivo do estudo. Resultados: foi encontrada a associação entre o polimorfismo da Apo A-1 -75G/A (rs670) e níveis mais reduzidos de triglicerídeos (TG) em pacientes com COVID-19, já o polimorfismo da Apo B (rs693) teve associação a redução dos níveis de TG apenas quando e codominância com o SNP -75G/A (rs670). Conclusão: os polimorfismos da Apo A-1 e Apo B desempenham um papel significativo no prognóstico e desenvolvimento da COVID-19, somado a isso é de suma importância o investimento em estudos, para assim haver o desenvolvimento de novas estratégias terapêuticas de intervenção baseadas no perfil genético do paciente, a fim de otimizar o tratamento e aumentar a sobrevida de indivíduos em estado crítico.
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Referências
AL-BUSTAN, S. et al. Re-sequencing of the APOAI promoter region and the genetic association of the-75G>A polymorphism with increased cholesterol and low density lipoprotein levels among a sample of the Kuwaiti population. BMC Medical Genetics, [S.L], v.14, n.90, 2013. DOI: https://doi.org/10.1186/1471-2350-14-90
ALVES, E. S. et al. The APOB rs693 polymorphism impacts the lipid profile of Brazilian older adults. Brazilian Journal of Medical and Biological Research, [S.L], v.53, n.3, p.e9102, 2020. DOI: https://doi.org/10.1590/1414-431x20199102
BEHBODIKHAH, J. et al. Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target. Metabolits, [S.L], v.11, n.690, 2021. DOI: https://doi.org/10.3390/metabo11100690
BEYERSTEDT, S., CASARO, E. B., RANGEL, É. B. COVID-19: angiotensin converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection. European Journal of Clinical Microbiology & Infectious Diseases, São Paulo, v. 40, p. 905-919, 2021. DOI: https://doi.org/10.1007/s10096-020-04138-6
CARRA, F. A. et al. The impact of obesity in hospitalized patients with COVID-19: a retrospective cohort study. Diabetology and Metabolic Syndrome, São Paulo, v.16, n.20, 2024.
COSTA, M. D. R. et al. Single nucleotide polymorphisms in apolipoprotein A-I (rs670) and B (rs693) associated with serum lipoproteins and endothelial activation in COVID-19 outpatients. Brazilian Journal of Pharmaceutical Sciences, Ceará, v.60, n.24015, 2024. DOI: https://doi.org/10.1590/s2175-97902024e24015
CARVALHO, J. C. S. et al. The Interplay among Glucocorticoid Therapy, Platelet-Activating Factor and Endocannabinoid Release Influences the Inflammatory Response to COVID-19. Viruses, São Paulo, v.15(2), n. 573, 2023. DOI: https://doi.org/10.3390/v15020573
FEINGOLD, K. R., GRUNFELD, C. Introduction to Lipids and Lipoproteins. National Library of Medicine, Califórnia, 2024.
FEINGOLD, K. R., GRUNFELD, C. Effect of Inflammation and Infection on Lipids and Lipoproteins. In Endotexto (internet), Califórnia, 2025.
GALLO, G., DESIDERI, G., SAVOIA, C. Update on Obesity and Cardiovascular Risk: From Pathophysiology to Clinical Management. Nutrients, Itália, v.16, n.2781, 2024. DOI: https://doi.org/10.3390/nu16162781
GALVÃO, M. H. R., RONCALLI, A. G. Fatores associados a maior risco de ocorrência de óbito por COVID-19: análise de sobrevivência com base em casos confirmados. Revista Brasileira de Epidemiologia, Natal, v. 23, p. e200106, 2020. DOI: https://doi.org/10.1590/1980-549720200106
GASPARIN, C. C., et al. Polymorphisms of APOE and APOB genes and dyslipidemias in a South Brazilian Cohort. Brazilian Journal of Implantology and Health Sciences, [S.L], v.6, n.1, p.992–1012, 2024. DOI: https://doi.org/10.36557/2674-8169.2024v6n1p992-1012
GOLIN, N., et al. Perfil lipídico de pacientes com diagnóstico de SARS-CoV-2 internados em unidades críticas de um hospital privado. Revista Da Associação Brasileira de Nutrição - RASBRAN, [S.L], v.12, n.4, p.88–98, 2022. DOI: https://doi.org/10.47320/rasbran.2021.2354
GOYAL, R. Comparative highlights on MERS-CoV, SARS-CoV-1, SARS-CoV-2, and NEO-CoV. EXCLI Journal, [S.L], v.1245-1272, 2022.
HUTTEN, C. G., et al. Obesity, Inflammation, and Clinical Outcomes in COVID-19: A Multicenter Prospective Cohort Study. The Journal of Clinical Endocrinology and Metabolism, [S.L], v.109, n.11, p. 2745-2753, 2024. DOI: https://doi.org/10.1210/clinem/dgae273
LAPIĆ, I., et al. Association of polymorphisms in genes encoding prothrombotic and cardiovascular risk factors with disease severity in COVID-19 patients: A pilot study. Journal of Medical Virology, [S.L], v.94, n.8, p.3669–3675, 2022. DOI: https://doi.org/10.1002/jmv.27774
LENT-SCHOCHET, D., JIALAL, I. Biochemistry, Lipoprotein Metabolism. StatPearls. [S.L], 2023.
Li, Y., et al. Lipid metabolism changes in patients with severe COVID-19. Clinica Chimica Acta, [S.L], v.517, p.66–73, 2021. DOI: https://doi.org/10.1016/j.cca.2021.02.011
MAKAROVA, Y. A., et al. Atherosclerosis, Cardiovascular Disorders and COVID-19: Comorbid Pathogenesis. Diagnostics, [S.L], v.13, n.3, p.478, 2023. DOI: https://doi.org/10.3390/diagnostics13030478
MENESES, R. R. C. Envolvimento do polimorfismo da apolipoproteina A1 (rs670) no tamanho e ação antioxidante da lipoproteína de alta densidade. 2023. 83 f. Tese de doutorado, Universidade Federal do Ceará. 2023.
MINISTÉRIO DA SAÚDE. COVID-19 No Brasil: Casos e Óbitos. Coronavírus Brasil. 2024.
MINISTÉRIO DA SAÚDE. (2025). Covid-19 - Casos e Óbitos. Ministério Da Saúde. 2025.
MOSCA, S., et al. Dyslipidemia Diagnosis and Treatment: Risk Stratification in Children and Adolescents. Journal of Nutrition and Metabolism, [S.L], n.4782344, 2022. DOI: https://doi.org/10.1155/2022/4782344
MUHEEB, G., et al. Association between lipid profile and clinical outcomes in COVID-19 patients. Scientific Reports, [S.L], v.14, n.1, p.1–12, 2024.
NURTAZINA, A. et al. Apolipoprotein B/A1 Ratio as a Diagnostic Alternative to Triglycerides and HDL-Cholesterol for the Prediction of Metabolic Syndrome among Hypertensives in Kazakhstan. Diagnostics, [S.L], v.10, n.510, 2020. DOI: https://doi.org/10.3390/diagnostics10080510
PAN AMERICAN HEALTH ORGANIZATION. One in eight people are now living with obesity. - PAHO/WHO | Pan American Health Organization. 2024.
PĂUNICĂ, I., et al. (2023). Comparative evaluation of LDL-CT, non-HDL/HDL ratio, and ApoB/ApoA1 in assessing CHD risk among patients with type 2 diabetes mellitus. Journal of Diabetes and Its Complications, [S.L], v.7, n.12, p.10863, 2023. DOI: https://doi.org/10.1016/j.jdiacomp.2023.108634
PUSHKAREV, V. V., et al. Plasma Apolipoproteins A1/B and OxLDL Levels in Patients with Covid-19 As Possible Markers of the Disease. Cytology and Genetics, [S.L], v.55, n.6, p.519–523, 2021. DOI: https://doi.org/10.3103/S0095452721060116
REZAEI, M. et al. ACE2: Its potential role and regulation in severe acute respiratory syndrome and COVID‐19. Journal of Cellular Physiology, Iran, v.236, p. 2430-2442, 2021. DOI: https://doi.org/10.1002/jcp.30041
SOUZA, T. V. et al. XbaI polymorphism in the APOB gene and its association with increased cholesterol in children and adolescents: Ouro Preto study. Scientific Reports, Minas Gerais, v.14(1), n.31452, 2024. DOI: https://doi.org/10.1038/s41598-024-83099-8
ULLOQUE-BADARACCO, J. R., et al. Prognostic value of apolipoproteins in COVID-19 patients: A systematic review and meta-analysis. Travel Medicine and Infectious Disease, [S.L], v.44, n.102200, 2021. DOI: https://doi.org/10.1016/j.tmaid.2021.102200
WONG, S. K., et al. Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence. Biomedicines, Malásia, v.10, n.12, p.3239, 2022. DOI: https://doi.org/10.3390/biomedicines10123239
YASEEN, R. I., et al. The relation between ApoB/ApoA-1 ratio and the severity of coronary artery disease in patients with acute coronary syndrome. Egyptian Heart Journal, [S.L], v.73, n.1, p.1–9, 2021. DOI: https://doi.org/10.1186/s43044-021-00150-z
ZHU, Z., et al. Low serum level of apolipoprotein A1 may predict the severity of COVID-19: A retrospective study. Journal of Clinical Laboratory Analysis, China, v.35, n.8, 2021. DOI: https://doi.org/10.1002/jcla.23911
