POLIMORFISMO DE LOS GENES APO-A Y APO-B Y EL PERFIL LIPÍDICO DE PACIENTES CON COVID-19: UNA REVISIÓN INTEGRATIVA
DOI:
https://doi.org/10.56238/arev7n12-058Palabras clave:
Apolipoproteína B, Apolipoproteína A-1, Obesidad, COVID-19, Polimorfismo GenéticoResumen
Objetivo: analizar la influencia de los polimorfismos de los genes APOA y APOB con el perfil lipídico de pacientes con COVID-19. Método: se realizó la búsqueda en las bases de datos Scholar Google, Biblioteca Virtual en Salud - BVS, Portal de Periódicos CAPES, y PubMed, utilizando los descriptores "Apo-B polymorphism AND SARS-Cov-2 AND COVID-19" y "Apo-A polymorphism AND Covid-19". Se seleccionaron estudios a partir de 2020 que fueran compatibles con el objetivo del estudio. Resultados: se encontró la asociación entre el polimorfismo de Apo A-1 -75G/A (rs670) y niveles más reducidos de triglicéridos (TG) en pacientes con COVID-19, ya que el polimorfismo de Apo B (rs693) tuvo asociación com la reducción de los niveles de TG solo cuando codominancia con el SNP -75G/A (rs670). Conclusión: los polimorfismos de Apo A-1 y Apo B juegan un papel significativo en el pronóstico y desarrollo del COVID-19, sumado a esto es de suma importancia la inversión en estúdios, para así tener el desarrollo de nuevas estrategias terapéuticas de intervención basadas en el perfil genético del paciente, con el fin de optimizar el tratamiento y aumentar la supervivencia de los individuos en estado crítico.
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