EMERGING TREATMENTS FOR INFECTIVE ENDOCARDITIS: THERAPEUTIC APPROACHES UNDER REVIEW

Abstract

Infective endocarditis (IE) is a serious clinical condition with a high mortality rate, especially if left untreated. This study presents a systematic review of the literature on emerging treatments for IE, addressing antimicrobial strategies and surgical interventions. The research included articles published between 2019 and 2024, using descriptors such as "infectious endocarditis". Modern antimicrobial approaches include the combined use of ceftriaxone and amoxicillin, as well as the transition to partially oral therapies in selected patients. Regarding surgical management, recommendations from international guidelines emphasize early interventions in cases of heart failure, persistent infection, or risk of embolization. Results point to the importance of a multidisciplinary approach, involving infectious disease specialists, cardiologists, and surgeons, in order to optimize outcomes and personalize treatments. Developments in guidelines for removal of implantable devices and for IE associated with cardiac interventions highlight the need for robust protocols and continued advances in the diagnosis and management of the disease.