PLANT-DERIVED MORIN AS A CONTROLLED-RELEASE ANTIMICROBIAL AGENT FOR PERIODONTAL THERAPY: A NATURAL ALTERNATIVE TO ANTIBIOTICS
DOI:
https://doi.org/10.56238/arev7n11-073Keywords:
Morin, Periodontal Disease, Controlled Release, Biopolymers, Antimicrobial Therapy, Natural ProductsAbstract
Objective:This narrative literature review aims to analyze current evidence on the potential use of morin, a natural flavonoid extracted from plants such as guava leaves, apple peels, and fig trees, as a controlled-release antimicrobial and anti-inflammatory agent for periodontal therapy. The focus is on its biological properties, formulation strategies using biopolymers, and its potential role as a natural alternative to conventional antibiotics in the management of periodontal disease.
Methodology: A comprehensive search was conducted in PubMed, Scopus, Web of Science, and Google Scholar databases using combinations of the keywords “Morin,” “Periodontal Disease,” “Controlled Release,” “Polymer,” and “Antimicrobial Agent.” Boolean operators “AND” and “OR” were used to refine results. Both in vitro and preclinical studies published in English between 2000 and 2025 were included, emphasizing the encapsulation of morin in biodegradable polymers and its biological effects on oral biofilms, inflammatory mediators, and tissue healing.
Results: The reviewed literature demonstrates that morin exhibits significant antimicrobial, anti-inflammatory, and antioxidant properties, reducing bacterial growth and oxidative stress associated with periodontal inflammation. In vitro studies conducted at the São Paulo State University (UNESP) have shown that morin-loaded polymeric microparticles, formulated with sodium alginate and gellan gum, promote controlled release and maintain biological activity against multispecies biofilms mimicking periodontal conditions. These systems may overcome the limitations of conventional antibiotics, such as bacterial resistance and undesirable side effects. However, clinical validation remains limited, and further animal and human trials are necessary to confirm efficacy and safety.
Conclusion: Morin-based delivery systems represent a promising, plant-derived alternative for adjunctive periodontal therapy, offering targeted antimicrobial activity and biocompatible release profiles. Standardization of polymeric formulations and clinical studies are required to translate these experimental findings into practical dental applications.
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References
Botelho, J., Machado, V., & Mendes, J. J. (2025). Antibiotics in periodontal treatment: An umbrella review. Frontiers in Cellular and Infection Microbiology, 15, Article 1601464. https://doi.org/10.3389/fcimb.2025.1601464
Brighenti, F. L., Sales, L. S., & Brighenti, F. (2025, September 30). A plant compound might be the secret weapon against gum disease. ScienceDaily. https://www.sciencedaily.com/releases/2025/09/250930034211.htm
Elashiry, M. (2021). Selective antimicrobial therapies for periodontitis. Frontiers in Microbiology, 12, Article 823553. https://doi.org/10.3389/fmicb.2021.823553
Higgins, J. P. T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M. J., & Welch, V. A. (Eds.). (2022). Cochrane handbook for systematic reviews of interventions (2nd ed.). John Wiley & Sons.
Kwon, H. J., Lee, Y. J., & Park, J. H. (2023). Anti-inflammatory and antimicrobial effects of plant flavonoids in experimental periodontitis. Journal of Periodontal Research, 58(4), 589–602. https://doi.org/10.1111/jre.13032
Sales, L. S., Brighenti, F. L., & Brighenti, F. (2025). Anti-inflammatory, antioxidant, and antimicrobial evaluation of morin. Archives of Oral Biology, 106, Article 106343. https://doi.org/10.1016/j.archoralbio.2025.106343
