EPIGENETIC EFFECTS OF THC EXPOSURE ON NEURODEVELOPMENT, A SYSTEMATIC REVIEW

Abstract

Introduction: The consumption of cannabis and THC has been increasing within the youth population at a national and global level. Perinatal THC consumption is a concern for its effects on neurodevelopment. Methodology. Se realizó una búsqueda de artículos siguiendo las directrices Prisma. Resultados: de 106 artículos iniciales sometidos a los filtros correspondientes, se seleccionaron 6.  There is experimental evidence at the genetic level that relates THC consumption and its effect on the endocannabinoid system but epigenetic effects are caused as a consequence of gene methylations directly involved in neurodevelopment processes. Conclusions and Conclusions: Damage in the processes of maturation of nervous tissue, neuronal migration, neurite formation, and synaptogenesis are evident at the level of structural, physiological, and behavioral cries.  It is necessary to follow the path of research in this line and design public policies that adviertan y protejan a la población sobre os efectos deletéreos que puede provoke el consumo de cannabis em la descendencia.