MULTIMODAL ANALYSIS AND MOLECULAR CHARACTERIZATION OF BENIGN CUTANEOUS PIGMENTED LESIONS: ADVANCES IN DIFFERENTIAL DIAGNOSIS AND IMPLICATIONS FOR DERMATOLOGICAL HEALTH

Abstract

Benign pigmented skin lesions are often mistaken for malignant conditions due to their visual similarity, making differential diagnosis a critical challenge in dermatology. This study aims to comprehensively analyze the multimodal and molecular characteristics of these lesions, employing cutting-edge imaging technologies and advanced genetic analysis. The research was conducted in a referral dermatology center, involving an observational study with 200 patients diagnosed with benign pigmented lesions. Techniques such as digital dermoscopy, skin reflectance spectroscopy, and next-generation genetic sequencing were used to investigate the molecular properties of the lesions. The results indicated specific pigmentation patterns and the presence of genetic markers that are essential to distinguish benign from malignant lesions. Multimodal analysis proved to be a powerful tool, providing a significant increase in diagnostic accuracy. Furthermore, the molecular findings suggest new perspectives for personalized treatment, enhancing the safety and efficacy of dermatological care. This study not only improves the understanding of the biology of pigmented lesions but also proposes the integration of molecular methods into conventional clinical practices. In conclusion, the multimodal and molecular approach is essential for the advancement of diagnostic techniques and may transform dermatological practice by offering more accurate diagnoses and safer clinical interventions.