EVALUATION OF C-REACTIVE PROTEIN, ACID GLYCOPROTEIN AND ERYTHROCYTE SEDIMENTATION RATE IN DOGS WITH HIP DYSPLASIA

Abstract

The objective of this study is to evaluate the inflammatory response in the hip joint in dysplastic dogs to compare laboratory findings of synovial fluid: nucleated cell count and its differential: mononucleated and polymorphonucleated cells, analysis of acute phase proteins: α1-acid glycoprotein, C-reactive protein and erythrocyte sedimentation rate, with radiographic findings of the hip joint in dogs with symptomatic and Asymptomatic. A total of 30 dogs were evaluated in the experiment, arranged in 3 experimental groups. The first group included 10 healthy animals (Control Group - CG), the second 10 animals with symptomatic hip dysplasia (Group 1 - G1) and the third 10 animals with hip dysplasia without symptoms (Group 2 - G2). A significant increase in ESR was observed in the symptomatic group, corroborating the hypothesis that in animals with clinical signs of the disease they present inflammation in the hip joint. ESR is useful in evaluating the inflammatory process in symptomatic dogs, indicating an acute inflammatory process. On the other hand, the measurement of AGP and CRP by immunoturbidimetry do not confer plausible results of inflammation in osteoarthrosis of dysplastic dogs, making it an ineffective biomarker for monitoring the disease. It suggests further studies of other inflammatory biomarkers for the disease studied.