PROFILE OF ALZHEIMER'S RESEARCH GROUPS IN BRAZIL: A BIBLIOMETRIC ANALYSIS

Authors

  • Jonas Pereira de Oliveira Neto Author
  • Hellen Karolainy Gomes de Oliveira Author
  • Carol de Oliveira Souto Author
  • Rodrigo Cid Barbosa de Mello e Silva Author
  • Mariana Leite Nunes de Brito Author
  • Gabrielly Vitória Fernandes Rocha Author
  • Milena Nunes Alves de Sousa Author

DOI:

https://doi.org/10.56238/arev8n6-025

Keywords:

Alzheimer’s Disease, Bibliometrics, Research Groups, Scientific Production, Aging

Abstract

Alzheimer's disease is one of the major global public health challenges, especially due to population aging and increased life expectancy. In this context, research groups play a fundamental role in the production and dissemination of scientific knowledge about the disease. This study aimed to analyze the profile of Brazilian research groups focused on Alzheimer's Disease. This is a bibliometric, descriptive study with a quantitative approach, developed using data obtained from the Research Groups Directory (DGP) of the National Council for Scientific and Technological Development (CNPq). The search was conducted using the descriptor “Alzheimer,” consulted in the Health Sciences Descriptors (DeCS). Groups that presented the term either in their name or in their research lines were included in the study. Five eligible groups were identified, mainly linked to the fields of Medicine, Biochemistry, and Pharmacy. Data were analyzed using the IRAMUTEQ software through the construction of a word cloud based on the research lines. The results showed a predominance of groups located in the Southeast region of Brazil, in addition to a strong connection with higher education institutions. Thematic diversity was observed in the studies, encompassing genetic, molecular, clinical, nutritional, and pharmacotherapeutic aspects related to Alzheimer's Disease. Heterogeneity in scientific production among the groups and limited international collaboration were also identified. It is concluded that Brazilian research groups demonstrate relevant scientific potential and growing interdisciplinarity, although challenges related to internationalization and the strengthening of collaborative networks still persist.

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References

AKSNES, D. W. et al. Citations, citation indicators, and research quality: an overview of basic concepts and theories. SAGE Open, v. 9, n. 1, 2019.

ALVES, G.; SILVA, F. Os desdobramentos do tamanho de grupos de pesquisa: uma revisão de literatura. Revista Ibero-Americana de Ciência da Informação, v. 15, n. 3, 2022.

ALZHEIMER’S ASSOCIATION. 2024 Alzheimer’s disease facts and figures. Alzheimer’s & Dementia, v. 20, n. 5, 2024.

ANKENY, S. E. et al. Navigating the landscape of plasma biomarkers in Alzheimer’s disease. Neurology and Therapy, v. 13, 2024.

BRASIL. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Diretório de Grupos de Pesquisa no Brasil (DGP). Disponível em: http://dgp.cnpq.br/dgp/faces/consulta/consulta_parametrizada.jsf. Acesso em: 30 abr. 2026.

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO (CNPq). Diretório dos Grupos de Pesquisa no Brasil (DGP): base de dados. Brasília, DF: CNPq, 2023. Disponível em: http://lattes.cnpq.br/web/dgp. Acesso em: 30 abr. 2026.

DETURE, M. A.; DICKSON, D. W. The neuropathological diagnosis of Alzheimer’s disease. Molecular Neurodegeneration, v. 14, n. 32, 2019.

DONTHU, N.; KUMAR, S.; MUKHERJEE, D.; PANDEY, N.; LIM, W. M. How to conduct a bibliometric analysis: an overview and guidelines. Journal of Business Research, v. 133, p. 285–296, 2021.

IBANEZ, A.; SLACHEVSKY, A. Environmental–genetic interactions in ageing and dementia across Latin America. Nature Reviews Neurology, v. 20, p. 571–572, 2024.

JACK, C. R. et al. NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease. Alzheimer’s & Dementia, v. 14, n. 4, p. 535–562, 2018.

KHAN, A. F.; ITURRIA-MEDINA, Y. Beyond the usual suspects: multi-factorial computational models in the search for neurodegenerative disease mechanisms. Translational Psychiatry, v. 14, n. 386, 2024.

KNOPMAN, D. S. et al. Alzheimer disease. Nature Reviews Disease Primers, v. 7, n. 33, 2021.

LIM, W. M.; TING, D. H.; NG, W. K.; CHIN, M. W. L. The evolving business of bibliometric analysis: A review and future directions. Journal of Business Research, v. 139, p. 1319–1330, 2022.

LINDERS, G. M.; LOUWERSE, M. M. Zipf’s law revisited: Spoken dialog, linguistic units, parameters, and the principle of least effort. Psychonomic Bulletin & Review, v. 30, p. 77–101, 2023.

LIU, E.; ZHANG, Y.; WANG, J.-Z. Updates in Alzheimer’s disease: from basic research to diagnosis and therapies. Translational Neurodegeneration, v. 13, n. 45, 2024.

LIVINGSTON, G. et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. The Lancet, v. 396, n. 10248, p. 413–446, 2020.

MANAP, A. S. A. et al. Alzheimer’s disease: a review on current trends of diagnosis and therapeutics. Frontiers in Aging Neuroscience, v. 16, 2024.

NICHOLS, E. et al. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019. The Lancet Public Health, Londres, v. 7, n. 2, p. e105-e125, 2022.

PINTO, R. S.; DINIZ, L. P. Impactos do exercício físico nos mecanismos neurobiológicos da Doença de Alzheimer. Revista FT, v. 29, ed. 145, abr. 2025. DOI: 10.69849/revistaft/cl10202504211114. Disponível em: https://revistaft.com.br/impactos-do-exercicio-fisico-nos-mecanismos-neurobiologicos-da-doenca-de-alzheimer/. Acesso em: 06 maio 2026.

PRINCE, M. et al. The global impact of dementia: an analysis of prevalence, incidence, cost and trends. London: Alzheimer’s Disease International, 2023.

RAMOS, A. A. et al. The landscape of dementia research in Brazil from 2010 to 2021: a Scopus-based bibliometric study. Arquivos de Neuro-Psiquiatria, v. 82, n. 11, p. 1–11, 2024.

SALVIATI, Maria Elisabeth. Manual do Aplicativo Iramuteq (versão 0.7 Alpha 2 e R Versão 3.2.3).

SANTOS, S. M.; KOBASHI, N. Y. Grupos de pesquisa no Brasil: dinâmica, produção e colaboração científica. Ciência da Informação, v. 51, n. 2, 2022.

SCHELTENS, P. et al. Alzheimer’s disease. The Lancet, v. 397, n. 10284, p. 1577–1590, 2021.

SILVA, et al. Produção científica nacional sobre cuidador familiar da pessoa idosa com doença de Alzheimer em domicílio. Editora Científica Digital, 2025. Disponível em: Editora Científica Digital. Acesso em: 9 maio 2026.

SMITH, M. A. C.; PAYÃO, S. L. M. Changes in expression of key genes in Alzheimer’s disease: a specific brain tissue change. The Journals of Gerontology: Series A, v. 79, n. 5, 2024.

SOSA, A. L. et al. Advancements in dementia research, diagnostics, and care in Latin America: Highlights from the 2023 Alzheimer's Association International Conference satellite symposium in Mexico City. Alzheimer’s & Dementia, v. 20, n. 7, p. 5009–5026, 2024.

STUDART-NETO, A. et al. Guidelines for the use and interpretation of Alzheimer’s disease biomarkers in clinical practice in Brazil: recommendations from the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology. Dementia & Neuropsychologia, v. 18, e2024C001, 2024.

TANG, X.; SHI, W.; WU, R.; LI, S. The expansion of team size in library and information science (LIS): Is bigger always better? Journal of Information Science, 2023.

VALENTE, A. M. A análise bibliométrica como ferramenta de avaliação da produção científica. Revista Acadêmica de Ciências, 2024. Disponível em: https://periodicos.newsciencepubl.com/arace/article/download/2087/2544/7623. Acesso em: 23 abr. 2026.

WORLD HEALTH ORGANIZATION (WHO). Dementia: a public health priority. Geneva: World Health Organization, 2023.

XIAO, X. et al. Metabolic dysfunction and mitochondrial failure in Alzheimer’s disease: integrating pathophysiology, clinical evidence and emerging interventions. Frontiers in Neurology, v. 17, 2026.

ZENG, B. et al. Pharmacologic and nutritional interventions for early Alzheimer’s disease: a systematic review and network meta-analysis of randomized controlled trials. Journal of Alzheimer’s Disease, v. 99, n. 4, p. 1173–1186, 2024.

Published

2026-06-05

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Articles

How to Cite

DE OLIVEIRA NETO, Jonas Pereira; DE OLIVEIRA, Hellen Karolainy Gomes; SOUTO, Carol de Oliveira; DE MELLO E SILVA, Rodrigo Cid Barbosa; DE BRITO, Mariana Leite Nunes; ROCHA, Gabrielly Vitória Fernandes; DE SOUSA, Milena Nunes Alves. PROFILE OF ALZHEIMER’S RESEARCH GROUPS IN BRAZIL: A BIBLIOMETRIC ANALYSIS. ARACÊ , [S. l.], v. 8, n. 6, p. e13377, 2026. DOI: 10.56238/arev8n6-025. Disponível em: https://periodicos.newsciencepubl.com/arace/article/view/13377. Acesso em: 5 jun. 2026.