EFFECT OF PHOTOBIOMODULATION ON HEALING OF POST-MINOR AMPUTATION ULCERS IN PATIENTS WITH DIABETES MELLITUS
DOI:
https://doi.org/10.56238/arev8n3-015Keywords:
Laser, Photobiomodulation, Ulcers, Amputations, Diabetes MellitusAbstract
Aims: To evaluate the effect of laser photobiomodulation on the closure of ulcers after minor amputations in patients with DM.
Method: 16 patients undergoing outpatient treatment in a public tertiary hospital were randomly divided into two groups. The conventional group was treated by cleaning the lesion with saline solution and using primary dressing; the photobiomodulation group received the conventional treatment+laser with λ=660nm, I=2.7W/cm2, H=108J/cm2, t=40s, E=4.32J. Each week the lesions were evaluated by measuring the area, perimeter, temperature, pH and glycemia levels. Statistical analysis was performed and the significance of all tests was =0.05.
Results: After 5 weeks there was no significant difference between groups, but 100% of the patients in the photobiomodulation group had granulation tissue, while in the conventional group it was 0% (p = 0.0014). By ROC curve was possible to establish that the cut-off for the arising of granulation tissue is 4 weeks. In addition, up to 18 laser treatment sessions increases the likelihood of ulcer closure, but beyond 18 sessions the probability starts to decrease, falling below 40%. It was also possible to determine the glycemic limit for the success of photobiomodulation: up to 225mg/dL.
Conclusion: Laser photobiomodulation with the parameters used accelerated the arising of the granulation tissue and provided 100% lesion cure in 6 patients. This study was also instrumental in determining the ideal number of sessions to maximize the likelihood of ulcer closure: once a week, for up to 18 weeks and with greater affectivity in patients with capillary glycemia below 225mg/dL.
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