LUNG TRANSPLANTATION IN A PATIENT WITH ACUTE SILICOSIS: A CASE REPORT
DOI:
https://doi.org/10.56238/arev8n2-141Keywords:
Silicosis, Respiratory Failure, Lung TransplantationAbstract
Acute silicosis is a rare and rapidly progressive form of occupational lung disease resulting from intense exposure to free silica, commonly occurring in activities such as sandblasting and stone grinding. It is characterized by the accumulation of proteinaceous material within the alveoli, leading to severe respiratory failure and a poor prognosis, with possible progression to death within two years. Despite a reduction in cases due to advances in personal protective measures, it remains an important diagnostic and therapeutic challenge. The objective is to describe the clinical, diagnostic, and therapeutic course of a patient with acute silicosis who underwent bilateral lung transplantation, highlighting the importance of early recognition and timely referral to specialized lung transplant centers. The methodology is based on a case report developed through retrospective analysis of clinical, laboratory, radiological, histopathological, and follow- up data from a patient treated at a tertiary public hospital in the Federal District, Brazil. The information was obtained through electronic medical record review. The case demonstrates that lung transplantation may represent an effective therapeutic alternative in selected cases of acute silicosis, particularly in young patients, reinforcing the relevance of early diagnosis and occupational prevention.
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GUTIERREZ, Tatiana Maron; GARCIA, Cristiane Sousa Nascimento Baez; MORALES, Marcelo Marcos; ROCCO, Patricia Rieken Macedo. Entendendo a fisiopatologia da silicose. Revista Pulmão RJ, Rio de Janeiro, v. 17, n. 1, p. 33–37, 2008.
BRASIL. Ministério da Saúde. Secretaria de Atenção à Saúde. Departamento de Ações Programáticas Estratégicas. Pneumoconioses. Brasília, DF: Ministério da Saúde, 2006. 76 p. (Série A: Normas e Manuais Técnicos; Protocolos de Complexidade Diferenciada, n. 6).
SOCIEDADE BRASILEIRA DE PNEUMOLOGIA E TISIOLOGIA. Capítulo 12. In: Jornal Brasileiro de Pneumologia, suplemento 52, v. 17, capítulo 12. Rio de Janeiro: SBPT,[2008].
BARBOZA, C. E. G. et al. Tuberculose e silicose: epidemiologia, diagnóstico e quimioprofilaxia. Jornal Brasileiro de Pneumologia, Brasília, v. 35, n. 5, p. 273–276, 2002.
BAUM, Lauren; ARNOLD, Thomas C. Silicosis. In: STATPEARLS. Treasure Island (FL): StatPearls Publishing, 2023.
CAMARGO, Paulo C. L. B. et al. Transplante pulmonar: indicações e resultados. Einstein (São Paulo), São Paulo, v. 13, n. 2, p. 297-304, 2015. DOI: https://doi.org/10.1590/S1679-45082015RW3156
PERIN, Felipe A. et al. Long-term survival following unilateral lung transplantation for end-stage silicosis relative to idiopathic pulmonary fibrosis. Jornal Brasileiro de Pneumologia, v. 48, n. 2, e20210379, 2022.
SOCIEDADE BRASILEIRA DE CIRURGIA TORÁCICA. Transplante de pulmão: indicações atuais. São Paulo: SBCT, 2003.
ANG, B.; LIU, X.; CHENG, P.; MENG, X.; JIA, Q. Silicosis: from pathogenesis to therapeutics. Frontiers in Pharmacology, v. 16, 29 jan. 2025. doi:10.3389/fphar.2025.1516200. DOI: https://doi.org/10.3389/fphar.2025.1516200
MCEWEN, Kate; BRODIE, Lyndell. Lung transplantation for silicosis and recovery: an Australian case study. British Journal of Nursing, v. 30, n. 3, p. 178–183, 11 fev. 2021. doi:10.12968/bjon.2021.30.3.178. DOI: https://doi.org/10.12968/bjon.2021.30.3.178
FUNDACENTRO. Eliminação da silicose é objetivo de programa nacional da Fundacentro. Brasília, 06 abr. 2004.
FUNDACENTRO. Publicação internacional destaca o Programa Nacional de Eliminação da Silicose. Brasília, 06 fev. 2016.
MAO, W. J.; CHEN, J. Y.; ZHENG, M. F.; CHEN, R.; HE, Y. J.; LIU, F.; YE, S. G.; LU, R. G. Lung transplantation for phase III silicosis: a series of 32 cases. Zhonghua Wai Ke Za Zhi, 54(12):902–907, 2016. DOI: 10.3760/cma.j.issn.0529-5815.2016.12.006.