COINFECÇÃO POR KLEBSIELLA PNEUMONIAE EM PACIENTES PEDIÁTRICOS COM COVID-19: UMA REVISÃO

Autores

  • Angelica de Lima das Chagas Autor
  • Jaqueline Correia Pontes Serra Autor
  • Jose Daniel Goncalves Vieira Autor
  • Lilian Carla Carneiro Autor

DOI:

https://doi.org/10.56238/arev7n10-267

Palavras-chave:

Resistência Antimicrobiana, COVID-19, Infecções Relacionadas à Assistência à Saúde (HIS), Klebsiella Pneumoniae, SARS-CoV-2

Resumo

A COVID-19 em pacientes pediátricos, embora frequentemente menos grave do que em adultos, pode ser complicada por coinfecções bacterianas, particularmente por Klebsiella pneumoniae (KP), um patógeno oportunista associado a altas taxas de resistência antimicrobiana e desfechos clínicos adversos. Este artigo revisa sistematicamente a literatura sobre coinfecção por KP em crianças com COVID-19, destacando sua prevalência, fatores de risco, impacto clínico e estratégias de manejo. Foi realizada uma revisão integrativa da literatura, abrangendo artigos publicados entre 2020 e 2025 nas bases de dados PubMed, Scopus, Web of Science e ScienceDirect. Foram incluídos estudos observacionais, retrospectivos e prospectivos, com foco em pacientes pediátricos diagnosticados com COVID-19 e coinfecção por KP. A análise temática identificou padrões de prevalência e gravidade clínica. Este estudo reforça que, embora a COVID-19 em crianças frequentemente apresente um curso leve a moderado, a coinfecção por KP representa um fator agravante e destaca a falta de estudos pediátricos robustos abordando a coinfecção por KP em pacientes pediátricos com COVID-19.

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Referências

1. Verani JR, Blau DM, Gurley ES, et al (2024) Child deaths caused by Klebsiella pneumoniae in sub-Saharan Africa and south Asia: a secondary analysis of Child Health and Mortality Prevention Surveillance (CHAMPS) data. Lancet Microbe 5:e131–e141. https://doi.org/10.1016/S2666-5247(23)00290-2

2. Kernéis S, Lucet JC, Santoro A, Meschiari M (2021) Individual and collective impact of Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae in patients admitted to the ICU. J Antimicrob Chemother 76:i19–i26. https://doi.org/10.1093/jac/dkaa494

3. Vidal DC, Kuzma J, Hensley J, et al (2023) AGE-BASED VARIABILITY OF ABSOLUTE LYMPHOCYTE COUNT IN CHILDREN WITH SEPTIC SHOCK. Crit Care Med 51:355. https://doi.org/10.1097/01.ccm.0000908648.28830.ae

4. Koutsogiannaki S, Kim S, Yuki K (2023) Age-dependent transcriptomic profiles of leukocytes in pediatric population. Clin Immunol Orlando Fla 255:109728. https://doi.org/10.1016/j.clim.2023.109728

5. Dumitru IM, Dumitrascu M, Vlad ND, et al (2021) Carbapenem-Resistant Klebsiella pneumoniae Associated with COVID-19. Antibiotics 10:561. https://doi.org/10.3390/antibiotics10050561

6. Lee J, Chang E, Jung J, et al (2022) Bacterial Co-Infection and Empirical Antibacterial Therapy in Patients With COVID-19. J Korean Med Sci 38:. https://doi.org/10.3346/jkms.2023.38.e37

7. Ahmad T, Khan M, Haroon, et al (2020) COVID-19: Zoonotic aspects. Travel Med Infect Dis 36:101607. https://doi.org/10.1016/j.tmaid.2020.101607

8. Ahmad W, Hernandez JA, Saini S, Mishra RK (2021) The US equity sectors, implied volatilities, and COVID-19: What does the spillover analysis reveal? Resour Policy 72:

9. Jia W, Wang J, Sun B, et al (2021) The Mechanisms and Animal Models of SARS-CoV-2 Infection. Front Cell Dev Biol 9:. https://doi.org/10.3389/fcell.2021.578825

10. Biskupek I, Sieradzan A, Czaplewski C, et al (2022) Theoretical Investigation of the Coronavirus SARS-CoV-2 (COVID-19) Infection Mechanism and Selectivity. Molecules 27:2080. https://doi.org/10.3390/molecules27072080

11. Khreefa Z, Barbier MT, Koksal AR, et al (2023) Pathogenesis and Mechanisms of SARS-CoV-2 Infection in the Intestine, Liver, and Pancreas. Cells 12:262. https://doi.org/10.3390/cells12020262

12. Morovati H, Eslami S, Bonab HF, et al (2022) Bacterial and fungal coinfections among patients with COVID-19 in Zanjan, Northwest of Iran; a single-center observational with meta-analysis of the literature. Iran J Microbiol 14:624–635. https://doi.org/10.18502/ijm.v14i5.10955

13. Murray CJ, Ikuta KS, Sharara F, et al (2022) Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. The Lancet 399:629–655. https://doi.org/10.1016/S0140-6736(21)02724-0

14. Binkhamis KM, Alhaider AS, Sayed AK, et al (2023) Prevalence of secondary infections and association with mortality rates of hospitalized COVID-19 patients. Ann Saudi Med 43:243–253. https://doi.org/10.5144/0256-4947.2023.243

15. Bender RG, Sirota SB, Swetschinski LR, et al (2024) Global, regional, and national incidence and mortality burden of non-COVID-19 lower respiratory infections and aetiologies, 1990–2021: a systematic analysis from the Global Burden of Disease Study 2021. Lancet Infect Dis 24:974–1002. https://doi.org/10.1016/S1473-3099(24)00176-2

16. Arcari G, Raponi G, Sacco F, et al (2021) Klebsiella pneumoniae infections in COVID-19 patients: a 2-month retrospective analysis in an Italian hospital. Int J Antimicrob Agents 57:106245. https://doi.org/10.1016/j.ijantimicag.2020.106245

17. Zhu X, Ge Y, Wu T, et al (2020) Co-infection with respiratory pathogens among COVID-2019 cases. Virus Res 285:198005. https://doi.org/10.1016/j.virusres.2020.198005

18. Braun V, and Clarke V (2006) Using thematic analysis in psychology. Qual Res Psychol 3:77–101. https://doi.org/10.1191/1478088706qp063oa

19. Barsanti G, Driutti M, Brunelli L, Cocconi R (2021) KPC rise in an Italian academic hospital during COVID‑19 pandemic. Italian, p 140

20. Sreenath K, Batra P, Vinayaraj EV, et al (2021) Coinfections with Other Respiratory Pathogens among Patients with COVID-19. Microbiol Spectr 9:10.1128/spectrum.00163-21. https://doi.org/10.1128/spectrum.00163-21

21. Ficik J, Andrezál M, Drahovská H, et al (2023) Carbapenem-Resistant Klebsiella pneumoniae in COVID-19 Era—Challenges and Solutions. Antibiotics 12:1285. https://doi.org/10.3390/antibiotics12081285

22. Li Q, Song M, Hu Z, et al (2024) Pediatric respiratory pathogen dynamics in Southern Sichuan, China: a retrospective analysis of gender, age, and seasonal trends. Front Pediatr 12:. https://doi.org/10.3389/fped.2024.1374571

23. Raychaudhuri D, Sarkar M, Roy A, et al (2021) COVID-19 and Co-infection in children: The Indian perspectives. J Trop Pediatr 67:. https://doi.org/10.1093/tropej/fmab073

24. Yakovlev AS, Afanasev VV, Alekseenko SI, et al (2024) Prevalence and Clinical Impact of Viral and Bacterial Coinfections in Hospitalized Children and Adolescents Aged under 18 Years with COVID-19 during the Omicron Wave in Russia. Viruses 16:1180. https://doi.org/10.3390/v16081180

25. Xu X, Meng L, Li J, et al (2025) Analysis of the potentially pathogenic bacteria of lower respiratory tract infections in children per-, during and post-COVID-19: a retrospective study. Eur J Clin Microbiol Infect Dis 44:167–180. https://doi.org/10.1007/s10096-024-04991-9

26. Yue Y, Wu D, Zeng Q, et al (2025) Changes in children respiratory infections pre and post COVID-19 pandemic. Front Cell Infect Microbiol 15:1549497. https://doi.org/10.3389/fcimb.2025.1549497

27. Singh V, Upadhyay P, Reddy J, Granger J (2021) SARS-CoV-2 respiratory co-infections: Incidence of viral and bacterial co-pathogens. Int J Infect Dis 105:617–620. https://doi.org/10.1016/j.ijid.2021.02.087

28. Ciptaningtyas VR, Hapsari R, Lestari ES, et al (2022) Bacterial colonization of the upper airways of children positive and negative for SARS-CoV-2 during the COVID-19 pandemic. BMC Infect Dis 22:860. https://doi.org/10.1186/s12879-022-07851-z

29. Ciptaningtyas VR, Mast Q de, Jonge MI de (2021) The burden and etiology of lower respiratory tract infections in children under five years of age in Indonesia. J Infect Dev Ctries 15:603–614. https://doi.org/10.3855/jidc.14268

30. Kenmoe S, Tcharnenwa C, Monamele GC, et al (2019) Comparison of FTD® respiratory pathogens 33 and a singleplex CDC assay for the detection of respiratory viruses: A study from Cameroon. Diagn Microbiol Infect Dis 94:236–242. https://doi.org/10.1016/j.diagmicrobio.2019.01.007

31. Sapra M, Kirubanandhan S, Kanta P, et al (2022) Respiratory viral infections other than SARS CoV-2 among the North Indian patients presenting with acute respiratory illness during the first COVID-19 wave. VirusDisease 33:57–64. https://doi.org/10.1007/s13337-022-00761-3

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Publicado

2025-10-28

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Como Citar

DAS CHAGAS, Angelica de Lima; SERRA, Jaqueline Correia Pontes; VIEIRA, Jose Daniel Goncalves; CARNEIRO, Lilian Carla. COINFECÇÃO POR KLEBSIELLA PNEUMONIAE EM PACIENTES PEDIÁTRICOS COM COVID-19: UMA REVISÃO. ARACÊ , [S. l.], v. 7, n. 10, p. e9345 , 2025. DOI: 10.56238/arev7n10-267. Disponível em: https://periodicos.newsciencepubl.com/arace/article/view/9345. Acesso em: 5 dez. 2025.