THE USE OF FIBRIN, PLATELET, AND LEUKOCYTE-RICH MEMBRANE (L-PRF) IN AESTHETIC DERMATOLOGY: A NARRATIVE REVIEW

Abstract

Introduction: The dermatological style has been developed using smaller and less dangerous techniques, driven by dissatisfaction with the status quo. Highlighted among the advances of L-PRF, which is an autologous procedure that causes cell regulation and collagen synthesis, without any pain and rejection. Even with the benefits, however, there are still problems in standardizing processes and obtaining demonstration of late effects. Objective: This study investigates the use of L-PRF (Leukocyte-Platelet Rich Fibrin) in aesthetic dermatology, highlighting its relevance in tissue regeneration and biostimulation, with the aim of evaluating its applications and efficacy in the treatment of various dermatological conditions. Methodology: A narrative review of the literature was carried out, with the selection of articles published between 2013 and 2024, prioritizing clinical and experimental studies that address the use of L-PRF in aesthetic dermatology. Key results: L-PRF has demonstrated significant benefits in facial rejuvenation, scar treatment, and accelerated tissue regeneration. In addition, studies indicate an improvement in the appearance of the skin, with positive effects in terms of elasticity, firmness and reduction of fine lines. Conclusion: L-PRF is an effective and safe therapy with great potential in aesthetic dermatology, although there are gaps in the standardization of protocols and in the variability of results. More in-depth studies are needed to validate its effectiveness and establish clear guidelines for application.