TRIMETHYLAMINURIA AND COGNITIVE BEHAVIORAL THERAPY AS AN INTERVENTION OPTION

Abstract

Trimethylaminuria (TMAU), known as fish odor syndrome, is a rare metabolic condition that prevents trimethylamine from metabolizing, resulting in intense and unpleasant body odor. This condition significantly impacts the quality of life of individuals, leading to social isolation, difficulties in work and school environments, and negatively affecting self-esteem. People with TMAU often face social stigmas, which can culminate in serious mental health problems such as anxiety, depression, and suicidal ideation. Although there is no cure for TMAU, symptoms can be managed through dietary interventions, pharmacology, and strict hygiene practices. In this context, psychotherapy, especially Cognitive-Behavioral Therapy (CBT), emerges as an essential tool. CBT offers a structured and evidence-based treatment, promoting not only emotional relief, but also autonomy and empowerment, which contributes to greater satisfaction with life, even in the face of the challenges imposed by the chronic condition. This therapeutic approach is constantly evolving, incorporating new practices that broaden the understanding of treatment. Techniques such as acceptance and mindfulness have become key, helping patients to embrace their internal experiences without judgment, which favors well-being. In addition, behavioral activation stimulates engagement in activities that provide pleasure and meaning, which are essential for emotional recovery. The evolution of CBT, which integrates methods from different disciplines, results in a more flexible approach that is adaptable to the needs of each individual. In this way, it seeks not only to treat the symptoms, but also to promote a significant transformation in the way patients deal with their emotions and relationships, favoring a more dignified and fulfilling life. Finally, it is crucial to invest in research in psychosocial areas to avoid biological reductionism in the treatment of TMAU. It is necessary to expand management and psychological support resources, with a deeper understanding of the condition and its impacts, especially in the training of health professionals. Thus, we will be able to offer more effective support, allowing patients to overcome their difficulties and achieve a life of greater quality and dignity.