EFFICACY OF TRANEXAMIC ACID PROPHYLAXIS IN REDUCING BLEEDING IN TOTAL KNEE ARTHROPLASTY: A SYSTEMATIC REVIEW
DOI:
https://doi.org/10.56238/levv17n56-048Keywords:
Tranexamic Acid, Knee Arthroplasty, Blood Loss, HemostasisAbstract
Introduction: Total knee arthroplasty is frequently associated with substantial perioperative blood loss, which may increase transfusion requirements and postoperative morbidity.
Objective: The main objective of this systematic review was to evaluate the efficacy of tranexamic acid prophylaxis in reducing bleeding in total knee arthroplasty, while secondary objectives included assessing safety outcomes, transfusion rates, optimal routes of administration, dosing strategies, and impacts on postoperative recovery.
Methods: A systematic search was conducted in PubMed, Scopus, Web of Science, Cochrane Library, LILACS, ClinicalTrials.gov, and the International Clinical Trials Registry Platform, including randomized and observational studies published within the last five years that evaluated tranexamic acid use in total knee arthroplasty.
Results and Discussion: A total of 20 studies were included, demonstrating that tranexamic acid significantly reduced total blood loss and transfusion rates without increasing thromboembolic complications, although heterogeneity was observed regarding administration routes and dosing protocols.
Conclusion: Current evidence supports the routine use of tranexamic acid as an effective and safe prophylactic strategy to reduce perioperative bleeding in total knee arthroplasty when applied within evidence-based protocols.
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References
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