The LUMEN ET VIRTUS (LEV) Journal, ISSN 2177-2789 QUALIS CAPES 2017-2020 B2, is a journal qualified in the following areas: Interdisciplinary; Public and Business Administration, Accounting Sciences, and Tourism; Anthropology/Archaeology; Arts; Communication and Information; Education; Teaching; Linguistics and Literature. This journal was edited by Editora Lumen et Virtus Ltda until June 30, 2024, but from July 1, it will be edited by New Science Publishers. All publications of this journal are on a continuous flow basis, with monthly editions. The articles accepted for publication are in the following languages: English, Spanish, and Portuguese. The scientific publications of academic articles include: scientific articles, literary reviews, bibliographic reviews, case studies, action research, among others.
INFLUENCE OF HERBAL MEDICINES ON THE WEIGHT LOSS PROCESS: AN INTEGRATIVE REVIEW
Obesity is a chronic disease characterized by excessive fat accumulation, resulting in a significant loss of quality of life and longevity. It involves a complex interaction of environmental factors such as lifestyle and sedentary behavior, as well as genetic factors. This condition has led the overweight population to seek ways to combat this pathology and associated comorbidities, giving visibility to what is currently known as phytotherapeutics, characterized as natural products. Phytotherapeutics have significant potential as a complement to conventional interventions in the treatment of obesity. This work consists of an integrative literature review. The research aimed to evaluate the use of phytotherapy in the weight loss process. The inclusion criteria were articles published in reliable databases from 2015 to 2025. The search was conducted using the combined descriptors "Weight loss" and "Phytotherapy," which were submitted to the PubMed, SciELO, and BVS databases. The Boolean operator "AND" was used to establish the relationship between the descriptors. Therefore, it can be concluded that herbal remedies have significant potential as a complement to conventional interventions in the treatment of obesity. However, their use should always be accompanied by professional guidance, and maintaining healthy lifestyle habits remains essential for achieving and preserving long-term results.
CARDIOVASCULAR RISKS ASSOCIATED WITH THE SYSTEMIC USE OF NAPHAZOLINE: AN INTEGRATIVE REVIEW
Naphazoline, an alpha-adrenergic sympathomimetic amine widely used in nasal decongestants and ophthalmic solutions, has systemic absorption potential that may lead to adverse cardiovascular effects. This integrative review aimed to critically analyze scientific evidence published between 2015 and 2025 regarding the cardiovascular risks associated with the systemic or abusive use of naphazoline. The search was conducted between November and December 2025 in the PubMed/MEDLINE, SciELO, and Scopus databases using controlled descriptors (DeCS/MeSH) related to naphazoline and its cardiovascular effects. Clinical studies, reviews, and case reports published in Portuguese, English, or Spanish addressing systemic effects or cardiovascular events were included, totaling 14 articles that met the inclusion criteria. The findings indicate a consistent association between systemic absorption of naphazoline and events such as hypertension, reflex bradycardia, arrhythmias, and myocardial ischemia. The main pathophysiological mechanism involves hyperstimulation of alpha-adrenergic receptors, resulting in intense vasoconstriction, increased peripheral vascular resistance, and reduced coronary blood flow. A recurrent pattern of self-medication and prolonged use was also observed, favored by over-the-counter availability and the mistaken perception of safety. It is concluded that naphazoline, although effective as a topical vasoconstrictor, presents clinically relevant cardiovascular toxicity potential when systemically absorbed. This review contributes to strengthening pharmacovigilance and highlights the need for regulatory measures and health education aimed at promoting the rational use of nasal decongestants.
Copyright (c) 2025 João Pedro Martins Napi Correa, Wesley Cássio de Souza Silva, André Gustavo Sampaio Costa, Wendel Marcelo Quaresma Ribeiro, Hyury Cesar Barros de Oliveira, Neuci Alves dos Santos Prata, Lígia Brambilla Costa, Nathalia Leite Lara Nunes, Angelo Coutinho Mazolini, Heloisa Maffioletti Ferrari, Marcos Antônio Forte Júnior, José Iracy Macário Barros Júnior, Ana Clara Cavalaro Zamboni, Adrieli Tavares Polate, Raynara Brito Silva, Dayana Assunção Nascimento, Pedro Costa Lima, Rafaella Abrantes e Silva, Carlos Arthur Marinho da Silva Beltrão, Luma Moreira Soares de Andrade, Adriane Brasileiro Mazocoli Silva, André Junior Lopez Lima, Hanna Fauzi Abdul Rahim, Marcos Phellype de Souza Kussler, Lucas Cardeal Simão Ribeiro (Author)
EFFECT OF PROBIOTIC AND PREBIOTIC SUPPLEMENTATION AS ADJUVANTS IN THE TREATMENT OF DEPRESSION: AN INTEGRATIVE REVIEW
Depression is a highly prevalent mental disorder that significantly impacts quality of life. Traditionally treated with pharmacological and psychotherapeutic approaches, new studies have explored the gut-brain axis as a complementary treatment pathway. In this context, the use of probiotics and prebiotics has gained prominence for its potential beneficial effects on mental health, positively influencing depressive symptoms. For this reason, the present study proposed, through an integrative literature review, to verify the use of these compounds in individuals with depressive disorders, seeking to highlight gaps in current knowledge and promote the connection between nutrition and mental health. The research was conducted by searching for studies available in the PubMed, Cochrane, and ScienceDirect databases, using the descriptors "Probiotics," "Prebiotics," and "Depression," combined with the Boolean operators "AND" and "OR." It is concluded that the use of probiotics and prebiotics as a supplementary therapeutic route indicates satisfactory results in the treatment of depressive symptoms. Taking into account the lack of standardization and continuous evaluation of the use of these supplements, it is important to emphasize that the results need to be analyzed diligently, so that the modulating effects will have greater support for their use. Consequently, it is also necessary to carry out more tests with specific dosage, time and methods for a more reliable result.
500 kVA SOLAR PHOTOVOLTAIC PLANT PROJECT FOR RURAL CONSUMER: LAW 14,300/2022 AND NORMATIVE RESOLUTION 482/2012
This work presents the technical design of a 500 kVA photovoltaic solar power plant, intended for a rural consumer located in Foz do Iguaçu, Paraná. The system was designed using 550 Wp photovoltaic modules installed on the ground, totaling an installed capacity of 462 kWp. The system is connected to the electrical grid through a 13.8 kV medium voltage substation with an oil transformer. The project follows the technical standards of ABNT and the regulatory requirements of ANEEL and the local utility company (COPEL), covering aspects such as solar radiation studies, system sizing criteria, equipment selection, energy performance analysis, and economic feasibility. The estimated annual generation is approximately 692,661 kWh, enough to meet the property’s entire energy demand. The economic analysis shows an investment return (payback) of less than 3 years, highlighting the technical and financial viability of the system. The implementation of solar power plants in rural areas represents a sustainable and economically attractive solution for cost reduction and energy independence.
NEUROLOGICAL MANIFESTATIONS AND THEIR PATHOPHYSIOLOGICAL MECHANISMS ASSOCIATED WITH HIV INFECTION: A LITERATURE REVIEW
The Central Nervous System (CNS) is an important target of infection by the Acquired Immunodeficiency Virus (HIV), which is detected in the initial stages of the disease in the cerebrospinal fluid and brain tissue, regardless of the clinical manifestations presented by the patient. Therefore, it is estimated that such neurological manifestations affect approximately 40% to 70% of HIV-infected individuals, representing the second most common site of clinical presentation of the pathology, behind only the Lymphoid System. At the same time, the impairment of the nervous system may be due to several mechanisms, namely: direct action of the virus itself, opportunistic infections, neoplasms, autoimmunity, cerebrovascular or metabolic disorders. So, a systematic review of the literature was conducted using the SciELO, Virtual Health Library (VHL) and Google Scholar platforms, applying strict criteria in order to select the articles which properly addressed the topic in question. The research results indicate that the diagnosis of neurological pathologies resulting from HIV infection are still underdiagnosed, either due to a lack of knowledge about them or the presence of subclinical manifestations which can be confused with other complications resulting from the immunosuppression state. It is concluded, due to the severity of neurological conditions and the high number of deaths underlying HIV infection in the CNS, that the topic is increasingly studied and fits into the range of differential diagnoses in immunosuppressed patients presenting neurological symptoms.
Maria Carolina dos Santos de Figueiredo Andrade
EXPOSURE OF CHILDREN TO ENVIRONMENTS WITH THE POTENTIAL TO COMPROMISE CHILD AND ADOLESCENT DEVELOPMENT IN BASIC HEALTH UNITS IN RIBEIRÃO PRETO, SÃO PAULO STATE
Neurodevelopment is influenced by the interaction of neurological and biological factors and the environment, such as education, daily stimuli, and healthy family relationships. Toxic stress, caused by intense and continuous adversity, can impair neurodevelopment. One risk factor for this ongoing stress is family dysfunction, especially parental alcohol and drug abuse. In this study, 194 pairs of children (or adolescents) and their guardians were assessed for alcohol and drug use and other impactful factors that could be associated with adversity in children or adolescents directly or indirectly exposed to these substances.
THE ROLE OF CIVIL SOCIETY IN CREATING INCLUSIVE CITIES
The purpose of this article is to analyze the relationship between the right to the city and housing policies in São Paulo, focusing on occupations promoted by housing movements in central areas. An interdisciplinary approach was adopted, combining normative analysis of urban and housing legislation with a bibliographical review of academic studies and official documents on social mobilization and participatory governance. The results showed occupations respond to a structural housing deficit resulting from historical processes of marginalization; that instruments of participatory democracy play a decisive role in the formulation and continuity of inclusive policies; and that the reuse of empty urban spaces for social housing strengthens the dialogue between civil society, public authorities and private initiative. In the end, we highlight the need to institutionalize participatory channels to ensure the continuity of these policies and propose investigating their applicability in other Brazilian metropolises.
FLYWHEEL SYSTEMS COUPLED TO BEARINGLESS MOTORS: LITERATURE REVIEW
With the growing need for more sustainable and efficient energy storage technologies, flywheel-based energy storage systems, such as Flywheel Energy Storage Systems (FESS), have become increasingly relevant in this context, especially when coupled with bearingless motors. This article presents a review of current flywheel systems coupled to bearingless motors, analyzing their topologies, control strategies, optimization, thermal performance, and emerging applications. In addition, the goal is to identify the most promising technological trends, research opportunities, and the main challenges faced. The results point to the great potential of flywheel systems with bearingless motors in critical applications, smart grids, electric vehicles, aerospace systems, and integration with other technologies in hybrid energy storage architectures.
DIFFICULT AIRWAY IN CRITICAL SCENARIOS: A SYSTEMATIC REVIEW ON ASSESSMENT, TECHNOLOGIES, AND PATIENT SAFETY
Objective: This systematic review aims to investigate the main strategies for the assessment and safe management of difficult airways in critically ill patients. Methodology: The research question was constructed using the PVO (Population, Variable, Objective) strategy. The literature search was performed in the PubMed, Embase, and Science Direct databases using the following English descriptors: (“difficult airway” OR “difficult intubation” OR “airway management”) AND (“critical care” OR “emergency department” OR “intensive care unit”) AND (“airway assessment” OR “predictive tests” OR ultrasound) AND (‘videolaryngoscopy’ OR “fiberoptic intubation”) AND (“patient safety” OR complications). Initially, 333 articles were identified. After applying the eligibility criteria, 12 studies were selected. Results: The identification and management of difficult airways in critically ill patients require integrated approaches that increase initial intubation success and reduce adverse events. Ultrasound has emerged as a useful complementary method, allowing assessment of subglottic anatomy, prediction of difficulties, and rapid confirmation of tube placement; studies show high agreement with radiography, especially using the tracheal rings method. During the intubation phase, videolaryngoscopy has demonstrated superiority over direct laryngoscopy, significantly reducing the need for multiple attempts. The use of bougie as an initial strategy (“bougie-first”), especially in combination with videolaryngoscopy, increased first-attempt success even during continuous chest compressions. Preoxygenation strategies also contribute to greater safety: high-flow nasal cannula (HFNC) proved superior to bag-valve mask in reducing desaturations and adverse events, maintaining continuous oxygenation during laryngoscopy. Conclusion: Taken together, the evidence indicates that the combination of video laryngoscopy, bougie-first, preoxygenation with HFNC, and ultrasound for assessment and confirmation represents the most effective set of contemporary strategies for recognizing and managing the difficult airway in critically ill patients.
HEMOPHAGOCYTIC SYNDROME SECONDARY TO ANTICONVULSANT-RELATED DRESS SYNDROME: A CASE REPORT
DRESS (Drug Reaction with Eosinophilia and Systemic Inflammation) is a serious adverse reaction that can present with significant multivisceral involvement. The exacerbated immune activation that occurs in DRESS syndrome can trigger hemophagocytic syndrome, generating intense systemic inflammation with unfavorable and potentially fatal clinical evolution. The association between hemophagocytic syndrome and DRESS is rare; however, early recognition of signs and symptoms is fundamental for timely diagnosis and treatment, reducing the likelihood of adverse outcomes and increasing the chances of therapeutic success.
Copyright (c) 2025 Caroline Cristina de Melo, Bianca Vieira Albanese, Lucas Ferreira Borges, Ana Luara Barcelos Silva, Francesco Carlo Maronese, Marcos Donisete Granado Júnior (Author)
AGING FOR WOMEN WHO DANCE BALLET, REDEFINING GETTING OLDER
The increase in the elderly population is a reality that requires new approaches aimed at rethinking concepts related to this topic. The present study sought to understand aging and the influences of practicing ballet for aging women, from the perspective of an artistic, expressive, and communicative practice. To this end, a literature review was carried out using articles that address this theme.In this way, it is observed that there are connections between aging and the practice of ballet for women, especially regarding the perception of their physical, cognitive, and psychosocial changes. The sense of belonging to a group and the perception of aging actively are evident in their views on growing older. The pursuit of long-delayed desires and dreams is re-signified in a reconstruction of identity through the perception of functionality and belonging.This allows us to conclude that ballet for older adults incorporates rhythms and choreographies in inclusive ways that respect limitations, while also seeking to break paradigms and provide physical exercise, concentration, memory development, and emotional well-being (Lima et al., 2021).
B12 DEFICIENCY AND BODY MASS INDEX: IS THERE A RELATIONSHIP IN UNIVERSITY STUDENTS? A CROSS-SECTIONAL STUDY
This cross-sectional study investigates the relationship between vitamin B12 deficiency and Body Mass Index (BMI) in female university students of childbearing age at a university in southern Brazil. Data were collected during the study ‘RELATIONSHIP BETWEEN IRON DEFICIENCY AND COGNITION IN UNIVERSITY WOMEN OF CHILDBEARING AGE,’ conducted in the second half of 2023. A total of 116 participants were included, with vitamin B12 dosage and BMI assessment. The median age of the participants was 22 years, with a median BMI of 23.1 and vitamin B12 of 356 pg/ml. The results did not show a statistically significant correlation between vitamin B12 and BMI. However, a post hoc analysis demonstrated a direct correlation between age and increased BMI, emphasising the need for attention to nutritional issues and their implications for public health.
OPHTHALMIC HYPERTENSION AND ITS MANAGEMENT: A SYSTEMATIC REVIEW
Ocular hypertension is defined as elevated intraocular pressure (IOP) without structural damage to the optic nerve or visual field defects. Although often asymptomatic, this condition is an important risk factor for the development of glaucoma. This study aimed to analyze, through a systematic review, the main therapeutic strategies used in the management of ocular hypertension. A total of 108 studies were identified, of which 10 met the inclusion criteria. The methodology followed PRISMA guidelines, with searches conducted in PubMed, Scopus, Web of Science, Medline Ovid, and SciELO. The selected studies addressed the use of hypotensive eye drops, combination therapies, surgical interventions, monitoring devices, and personalized approaches. The results showed that early and individualized IOP reduction is associated with a lower rate of progression to glaucoma. It is concluded that effective management of ocular hypertension requires a multifactorial approach, treatment adherence, continuous risk assessment, and integration of technologies that enhance precision and therapeutic compliance
BIOMECHANICAL ANALYSIS PERFORMED ON LAMB FORELEGS COMPARING TRANSOSSEOUS REPAIR AND TRANSOSSEOUS REPAIR ASSOCIATED WITH ANCHOR FIXATION IN DISTAL TRICEPS LESIONS
Objective: To biomechanically compare two forms of triceps tendon repair (isolated transosseous suture versus transosseous suture associated with a metallic anchor). Method: The tests involved triceps tendon repairs in 8 forelimbs of goats, equally divided into the two repair type subgroups, and subjected to pull-out forces measured with a tensiometer. Result: The study concludes that the combined repair (transosseous suture associated with an anchor) was biomechanically superior to the isolated transosseous suture, although it acknowledges limitations such as the absence of tests in humans. Conclusions: Although there is no consensus on the best surgical repair technique for distal triceps injuries, the greater biomechanical resistance of the repair is a decisive factor for early rehabilitation and overall therapeutic success. Thus, the greater biomechanical resistance of the combined repair has the potential to generate greater benefit compared to the isolated repair technique.
PERIPHERAL ULCERATIVE KERATITIS - MOOREN'S ULCER: CHALLENGES IN DIAGNOSIS AND TREATMENT
Peripheral ulcerative keratitis encompasses a group of predominantly autoimmune disorders characterized by progressive stromal destruction at the corneal periphery and a high risk of perforation. Among its variants, Mooren’s ulcer stands out as an exclusively ocular condition with an aggressive, unpredictable course and no established association with systemic disease. This review critically examined the epidemiology, pathophysiology, diagnostic challenges, and therapeutic strategies related to this entity, integrating both classical insights and contemporary evidence. Findings indicate that stromal degradation results from a complex autoimmune inflammatory cascade, supporting the early use of systemic immunosuppression tailored to disease severity. Surgical interventions remain essential in cases of impending perforation or therapeutic refractoriness. Despite significant advances, important gaps persist, especially regarding recurrence prediction and the establishment of standardized treatment protocols. Effective management requires multidisciplinary coordination, long-term monitoring, and continuous integration of emerging evidence to enhance visual outcomes.
SELECTION OF ALPHA-AMYLASE PRODUCING BACTERIAL ISOLATES FROM AMAZONIAN AQUATIC ECOSYSTEM
The Amazonian biodiversity represents a significant source of biomolecules with potential for biotechnological application. This biodiversity can be harnessed for the development of inputs applicable to the industrial sector. In this context, bacteria possess the ability to secrete enzymes that can serve various purposes, and enzyme prospecting is considered fundamental for Brazil's socioeconomic development. Given this, the objective of this project was to prospect for alpha-amylase from the bacterial microbiota of an Amazonian aquatic ecosystem. To achieve this, water samples were collected from Lake Mamiá in the mid-Solimões region (Coari-AM) between 2022 and 2023. Subsequently, bacterial isolates with the capacity to hydrolyze starch were identified. Total DNA was then extracted from the amylolytic bacteria for amplification of the 16S Ribosomal RNA genes. Furthermore, the physicochemical conditions (Temperature, pH, and Electrical Conductivity) of the aquatic ecosystem were measured, alongside qualitative and quantitative analyses of alpha-amylase activity. In conclusion, the prospecting of enzymes from the bacterial microbiota of the Amazonian aquatic ecosystem is of fundamental importance for the search for novel biomolecules that meet industrial needs in bioprocesses, as well as for the enzyme's potential application in ethanol production from the processing and fermentation of cassava starch cultivated in the Amazon region.
PHARMACIST-BASED PRIMARY CARE: A CASE STUDY OF BRAZILIAN PRACTICE DURING THE PANDEMIC
The study analyzes the role of pharmacists in Brazilian primary care during the pandemic, highlighting how these professionals assumed essential clinical, educational, and organizational functions to ensure continuity of care in a period marked by sanitary instability and high service demand. The literature review shows that pharmacists helped qualify medication use, guide patients, reorganize internal workflows, strengthen health education actions, and support individuals with chronic conditions, reducing risks and promoting interventions aligned with the population’s emerging needs. Evidence indicates that practices such as telepharmacy, pharmacotherapeutic review, supply management, and community-oriented communication became important for maintaining therapeutic safety and increasing the effectiveness of health services. The pandemic underscored the importance of integrating pharmacists strategically into multidisciplinary teams, revealing that their actions are vital in structuring services, preventing clinical deterioration, and reinforcing public health policies. The findings emphasize that valuing pharmacists is essential for consolidating more efficient, human-centered, and sustainable models of care within primary health systems.
APPLICATIONS OF ARTIFICIAL INTELLIGENCE IN METABOLIC HEALTH
Artificial intelligence has expanded the possibilities for interpreting metabolic processes by enabling large volumes of clinical, nutritional and behavioral data to be examined in an integrated manner, supporting the identification of patterns that contribute to risk anticipation, the refinement of preventive strategies and the development of clinical approaches aligned with the physiological singularities of each individual, consolidating a model of care based on continuous and in-depth reading of metabolic variations and reinforcing interventions grounded in robust information that reflects biological and social realities observed in different health contexts. This study describes and discusses the application of artificial intelligence in metabolic monitoring, highlighting its ability to enhance practices related to the prediction of chronic diseases and the monitoring of clinical indicators that directly influence human metabolic evolution, allowing the development of more personalized strategies adapted to contemporary clinical demands, contributing to the expansion of scientific knowledge and to the construction of care models that integrate technology, predictive analysis and comprehensive understanding of the patient as central elements in promoting more consistent and effective clinical outcomes.
THE IMPACTS OF OBESITY ON PUBLIC HEALTH: AN EVIDENCE-BASED APPROACH
This study examined the impacts of obesity on public health through a bibliographic review that brought together recent evidence on epidemiological trends, clinical repercussions, and the social and economic effects associated with excessive body weight, enabling a comprehensive understanding of the phenomenon’s multifactorial nature. The investigation showed that changes in eating patterns, increased consumption of ultra-processed foods, and progressively sedentary routines contribute to rising obesity rates across age groups, highlighting the need for continuous prevention strategies and public policies that promote healthier food environments. The findings revealed that socioeconomic inequalities, limited access to nutritious foods, and reduced opportunities for physical activity intensify vulnerabilities and underscore the importance of interventions tailored to territorial specificities, especially among children, adolescents, and low-income populations. The review also demonstrated that obesity affects work capacity, increases healthcare and economic costs, and generates emotional strain and family-related challenges that reinforce cycles of illness. The evidence points to the relevance of intersectoral actions integrating health, education, social assistance, and urban planning, aiming to strengthen preventive measures and expand comprehensive care strategies designed to reduce the burdens associated with excessive weight.
INTEGRATION OF GPS TRACKING SYSTEMS IN URBAN LOGISTICS
Urban logistics has emerged as a strategic field as cities expand and demand analytical systems capable of precisely interpreting the behavior of freight vehicles, a context in which GPS tracking data stand out as an essential source for studies requiring high levels of operational detail. The literature shows that continuous records enable the identification of movement patterns, stop durations, spatial distribution of operations, and fluctuating traffic conditions, providing analytical support for a deeper understanding of logistic dynamics in urban environments. Research conducted in different regions demonstrates that the integration of georeferenced data, advanced processing techniques, and spatial analysis methods strengthens diagnostic capacity regarding urban performance, contributing to the identification of bottlenecks, assessment of corridor efficiency, and comprehension of interactions between infrastructure and operational flows. Based on the bibliographic review, GPS tracking was found to have evolved from a security-oriented tool to a structural instrument for planning and management, enabling public and private strategies to be formulated on the basis of empirical evidence. The findings indicate that continuous use of these technologies offers greater precision for scenario modeling, supports policies for reorganizing freight circulation, and enhances logistical practices in urban settings, demonstrating that systematic application of GPS data represents a significant advancement toward efficiency, sustainability, and rational management of freight transport.
ADVANCES IN THE TREATMENT OF METHANOL POISONING: A REVIEW OF CURRENT CLINICAL EVIDENCE
Methanol poisoning is a serious global public health problem, associated with high morbidity and mortality rates and outbreaks related to the consumption of adulterated beverages. This study aimed to identify, analyze, and synthesize recent clinical evidence on treatment strategies for methanol poisoning, with an emphasis on therapeutic and organizational advances over the last decade. This is an integrative literature review, conducted according to the steps proposed by Whittemore and Knafl (2005). The search was conducted in the PubMed, SciELO, Scopus, and Consensus Database between November and December 2025, using the descriptors “methanol poisoning,” “treatment,” “fomepizole,” “ethanol therapy,” and “hemodialysis.” A total of 216 studies were identified, of which 12 met the inclusion criteria (publications between 2013 and 2025, full text, and clinical-therapeutic focus). The evidence points to fomepizole as the first-choice antidote and early hemodialysis as a determining factor in reducing mortality and neurological sequelae. Standardized clinical protocols and multidisciplinary teams contributed to greater effectiveness and speed of care. It is concluded that this review contributes to consolidating the clinical evidence on the treatment of methanol poisoning, providing support for evidence-based practice and the formulation of public policies focused on clinical toxicology.
IMPACT OF IMMUNOSUPPRESSION ON THE PERIOPERATIVE MANAGEMENT OF PATIENTS WITH PIGMENTARY AUTOIMMUNE DISEASES, ESPECIALLY VOGT–KOYANAGI–HARADA SYNDROME
Introduction: Vogt-Koyanagi-Harada (VKH) syndrome is an autoimmune disorder mediated by CD4+ T lymphocytes, requiring prolonged treatment with corticosteroids and immunosuppressive agents. Although essential for inflammatory control, these therapies significantly influence perioperative risk. This study provides a systematic review of the evidence regarding perioperative management in immunosuppressed patients with pigmentary autoimmune diseases, with a focus on VKH. Methods: A systematic review was conducted in PubMed, Scopus, Web of Science, and the Cochrane Library (2000–2024) using combinations of descriptors related to VKH, immunosuppression, and surgical complications. Eligible studies included clinical trials, observational studies, reviews, and clinical guidelines addressing the impact of corticosteroids, immunomodulators, or biologic agents in the perioperative setting. Results: Fifteen studies met the inclusion criteria. Corticosteroid use was consistently associated with impaired wound healing, increased infection rates, and relative adrenal insufficiency. Immunomodulators such as mycophenolate mofetil, azathioprine, and cyclosporine were linked to heightened susceptibility to infections and delayed tissue repair, particularly in major surgeries. Biologic agents demonstrated the highest risk of deep infections, supporting guideline recommendations for suspending these therapies for one to two dosing cycles before surgery. International guidelines consistently emphasize individualized perioperative decisions based on drug class, duration of immunosuppression, and disease stability. Conclusion: Patients with VKH receiving immunosuppressive therapy face substantially increased perioperative risks. Multidisciplinary planning involving ophthalmology, surgery, and anesthesiology is essential. Implementing evidence-based perioperative strategies may reduce complications and improve outcomes in this vulnerable population.
THE ROLE OF THE DATA PROTECTION OFFICER IN THE POST-LGPD CORPORATE STRUCTURE
This article presents a critical analysis of the strategic role of the Data Protection Officer (DPO) within the organizational structure of Brazilian companies following the enactment of the General Data Protection Law (LGPD). It historically contextualizes the legislation and its relationship with the European Union’s General Data Protection Regulation (GDPR), highlighting the influence of international standards on the formulation of the Brazilian law. The impact of the LGPD on corporate governance is examined, emphasizing the structural adjustments necessary to ensure regulatory compliance, transparency, and the strengthening of data subjects’ trust. The study outlines the responsibilities of the DPO and their function as an intermediary between the company, data subjects, and the National Data Protection Authority (ANPD), addressing the technical, legal, and interpersonal competencies essential for performing this role. It also discusses the challenges related to integrating this professional into the strategic and operational processes of organizations, as well as recommended practices in information governance, digital compliance, and risk management, with an emphasis on the importance of an organizational culture focused on ethics, security, and the protection of personal data. It concludes that the DPO should not be understood merely as a legal requirement but as a strategic agent essential for corporate sustainability and for the establishment of responsible and competitive business environments in a context of increasing appreciation of privacy.
RELATIONSHIP BETWEEN BREASTFEEDING AND THE DEVELOPMENT OF THE INTESTINAL MICROBIOTA IN INFANTS: AN INTEGRATIVE REVIEW
Exclusive breastfeeding (EBF) is recognized as the gold standard in infant nutrition, with significant impacts on the development of the gut microbiota. This microbial community performs essential functions in immune and metabolic modulation, and its correct formation is fundamental for the prevention of diseases throughout life. Therefore, the objective of this study was to evaluate the relationship between EBF and the development of the gut microbiota in infants. A literature search was conducted, covering articles published between 2015 and 2025 through the PubMed, Virtual Health Library (VHL), and ScienceDirect databases. The search strategy used combined descriptors such as “Breastfeeding,” “Gastrointestinal Microbiome,” and “Infants.” After screening, three studies were included that demonstrate that EBF modulates the gut microbiota through oligosaccharides (HMOs), promoting colonization by Bifidobacterium and Lachnospiraceae, mitigating the impact of external factors such as cesarean delivery, and is associated with systemic protection, including reduced risk of asthma through balanced nasal and intestinal colonization. Therefore, even though AME acts as a decisive modulator in the intestinal microbiota, with effects on the prevention of metabolic, allergic, and immunological diseases, further studies are needed to deepen this relationship, since the studies found for this integrative review are still limited.
Francileide do Nascimento Ferreira Lemos
TECNOLOGIAS ASSISTIVAS E O DIREITO À EDUCAÇÃO INCLUSIVA
O presente artigo teve como objetivo analisar o papel das tecnologias assistivas na promoção de uma educação inclusiva na etapa básica do ensino, com ênfase em sua aplicação pedagógica. O estudo abordou a utilização de recursos tecnológicos como facilitadores do acesso, da permanência e da participação de estudantes com deficiência no ambiente escolar. A pesquisa, de caráter qualitativo, utilizou o método bibliográfico para examinar artigos científicos publicados entre 2017 e 2025, selecionados por meio da base CAPES Periódicos, a partir de critérios de relevância temática e temporalidade. Foram analisadas produções que discutem a prática pedagógica com tecnologia assistiva, sua função no cumprimento do direito à educação e sua categorização funcional. Os resultados evidenciaram que a efetividade desses recursos depende da formação docente, da intencionalidade no uso pedagógico e da existência de políticas institucionais de suporte. Verificou-se, ainda, que muitos professores utilizam estratégias assistivas de modo intuitivo, sem conhecimento conceitual formal sobre sua função inclusiva, o que limita o impacto das ferramentas disponíveis. Concluiu-se que, embora as tecnologias assistivas estejam presentes no cotidiano escolar, sua utilização plena requer condições institucionais e pedagógicas que nem sempre estão garantidas. A pesquisa reforçou a necessidade de ações formativas e políticas públicas voltadas à integração efetiva desses recursos nos contextos escolares.
Copyright (c) 2025 Leila Ribeiro dos Santos Soares, Lívia Rodrigues Nogueira, Thiely Fonseca de Almeida, Pedro Soares Magalhães, Marianne Maluma Alves Portilho (Author)
PREPARO DE MOLAR INFERIOR COM LIMA ROTATÓRIA PORTADOR DE CURVATURA ABRUPTA DA RAIZ DISTAL – RELATO DE CASO
Paciente do sexo masculino, 49 anos, sem histórico de doenças sistêmicas, procurou consultório particular, queixando-se de dor no dente 36. A radiografia comprovou cárie secundária. Radiograficamente, observou-se canal radicular portador de curvatura abrupta da raiz distal. O preparo realizado com o sistema rotatório da Solla Collors #35.04 até alcançar o comprimento de trabalho estabelecido. A patência foraminal com a lima de Glide path Solla Collors 16/02. A obturação foi realizada pela técnica do cone único associado ao cimento Bio-C Sealer. Conclui-se que o preparo com limas Solla Collors determina uma adequada formatação e modelagem de canais radiculares de molar inferior portador de curvatura abrupta.
Copyright (c) 2025 Rosana Maria Coelho Travassos , Samuel Nogueira Lima, Tereza Cristina Correia, Adriane Tenório Dourado Chaves, Erika Milagros Vilca Wanderley, Josué Alves, Priscila Prosini, Alexandre Batista Lopes do Nascimento, Hilcia Mezzalira Texeira, Verônica Maria de Sá Rodrigues, Viviane Ferreira Guimarães Xavier, Vanessa Lessa Cavalcanti de Araújo (Author)
EFEITOS DA SUPLEMENTAÇÃO DE MAGNÉSIO NA QUALIDADE DO SONO EM ADULTOS COM INSÔNIA: UMA REVISÃO INTEGRATIVA
A insônia afeta grande parte dos adultos e pode estar relacionada à deficiência de magnésio, mineral envolvido na regulação de neurotransmissores e na síntese de melatonina. Nesse contexto, a suplementação de magnésio vem sendo investigada como uma alternativa para a melhora da qualidade do sono. Este estudo teve como objetivo analisar os efeitos da suplementação de magnésio na qualidade do sono em adultos por meio de uma revisão integrativa, realizada nas bases de dados Scientific Electronic Library Online (SciELO), National Library of Medicine (PubMed) e Biblioteca Virtual em Saúde (BVS). Foram utilizados descritores controlados (DeCS/MeSH), combinados a operadores booleanos AND e OR, com as seguintes combinações: “Supplemental health AND Magnesium AND Sleep” e "Magnesium AND Sleep Initiation AND maintenance disorders". A busca foi realizada entre julho e novembro de 2025, considerando estudos publicados nos últimos oito anos. A qualidade metodológica dos estudos incluídos foi conduzida utilizando a ferramenta AMSTAR 2 (A MeaSurement Tool to Assess Systematic Reviews). Os resultados sugerem que, especialmente na forma de L-treonato de magnésio 1g/dia, o mineral pode melhorar a qualidade do sono, o humor e os níveis de melatonina. Conclui-se que o magnésio apresenta potencial como adjuvante não farmacológico na melhora do sono. Contudo, são necessários mais ensaios clínicos que avaliem diferentes formulações, dosagens e o uso a longo prazo.
Magnésio e Distúrbios de Início e Manutenção do Sono
Copyright (c) 2025 Luana Niuma Bezerra, Débora Thaís Sampaio da Silva, Ana Karine de Oliveira Soares, Tamires da Cunha Soares, Lívhya Maria Dias Alves, Kauanny da Silva Rodrigues, Jhuan Carlos Batista da Silva, Maria Alany Ferreira dos Santos (Author)
CRANIAL ASYMMETRY IN INFANTS BETWEEN 4 AND 12 MONTHS OF AGE
There are several types of cranial asymmetry, such as plagiocephaly, brachycephaly, and scaphocephaly. The causes may include gestational age, prenatal factors, and postnatal factors such as the infant’s habitual positioning during the day. Diagnosis should be made by a pediatrician or physician who monitors the newborn’s growth and development. Treatment can be performed through proper positioning care and, in some cases, with the use of cranial orthoses. This study aims to address cranial asymmetry, its types, diagnostic methods, and possible treatments based on scientific articles and studies conducted by professionals in the field.
SURGICAL CORRECTION OF ALTERED PASSIVE ERUPTION WITH RESTORATION OF THE DENTOGENGIVAL COMPLEX: CASE REPORT
The smile plays a fundamental role in facial aesthetics and social perception, and changes in its harmony have received increasing attention in contemporary dentistry. Excessive exposure of the gums when smiling, known as a “gummy smile,” is usually diagnosed when the gum display exceeds 3 mm, which can compromise aesthetics. Its etiology is multifactorial, including altered passive eruption (APE), genetic factors, and drug-induced changes. The aim of this study was to report the clinical-surgical management of a case of type I, subtype B APE, treated by aesthetic clinical crown lengthening associated with osteotomy and osteoplasty. The surgical procedure involved an internal bevel incision to remove the gingival collar, preservation of the interdental papillae, and elevation of the mucoperiosteal flap by sulcular incision, allowing access to the bone tissue to restore the biological distance of 3 mm. The clinical outcome demonstrated an excellent aesthetic and functional response, reinforcing the importance of accurate diagnosis, adequate surgical planning, and careful technical execution to achieve predictable healing and minimize complications.
APPLICATION OF THE MASP METHODOLOGY FOR IMPROVING THE BLBP INDICATOR IN A STEEL ROLLING INDUSTRY
H This article investigates the reduction of production losses in a steel rolling industry, with a focus on improving the BLBP indicator (Rolled Bars per Lost Bar), considering that high scrap rates directly impact operating costs, metal yield, and line efficiency, the Problem Analysis and Solution Method (MASP) was applied in conjunction with quality tools such as Pareto analysis, Ishikawa diagram, the 5 Whys, and the 5W2H plan. A detailed analysis of the company’s operational data made it possible to identify root causes mainly associated with the Continuous Mill and the Roughing Mill. After the implementation of the proposed corrective actions, an improvement in the BLBP index and a reduction in losses were observed, demonstrating the effectiveness of the adopted methodology and its relevance to industrial competitiveness.