EVASION OF THE IMMUNE RESPONSE IN PROSTATE CANCER: ROLE OF THE TUMOR MICROENVIRONMENT
DOI:
https://doi.org/10.56238/10.56238/levv16n54-050Keywords:
Neoplasia, Immune Mediators, Immune Mechanism, ImmunotherapyAbstract
Introduction: Prostate cancer (CaP) is one of the most prevalent neoplasms among men, with a high incidence and mortality rate. In 2022, 1,467,854 cases and 397,430 deaths were recorded globally. In Brazil, PCa is the most diagnosed among men, with 71,730 new cases in 2023. The disease is characterized by the uncontrolled proliferation of tumor cells and the evasion of the immune response, facilitating metastasis. Objective: Given this scenario, the present work aimed to unveil the cancer growth process, with emphasis on the role of the tumor microenvironment and its role in evading the immune response. Methodology: This study was carried out through a literature review, using contemporary academic sources. The research focused on the descriptive analysis of interactions between the tumor microenvironment (MAT) and the immune response in the context of prostate cancer, covering publications from 2015 to 2025. Results: The tumor microenvironment plays a crucial role in the progression of PCa, creating immunosuppressive conditions that favor the survival of tumor cells. MAT cells secrete factors that inhibit the immune system's response, making it difficult to eliminate cancer cells. Conclusion: The complexity of MAT represents a significant challenge to the effectiveness of available therapies for PCa. Early detection of the disease is essential to improve the prognosis of patients. Continuing research into new therapies is essential for developing strategies that can overcome the barriers imposed by the tumor microenvironment.
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