COMPARISON OF THE EFFECT OF SELENIUM AND GLUTAMIN SUPPLEMENTATION ON INCREASE T-CD4 LYMPHOCYTE COUNT
DOI:
https://doi.org/10.56238/levv16n54-023Keywords:
Nutrilogy, Selenium, Glutamine, Imune System, CD4 T lymphocytesAbstract
Background: Nutritional interventions based on the intake adequacy of certain micronutrients can to improve CD4 T cell count. Aim: To review the literature on nutritional supplementation with selenium or glutamine to increase CD4 T lymphocyte counts. Method: The base chosen for the papers selection was PUBMED, using the following search strategy: (selenium [title] OR glutamine [title]) AND CD4 [title]. No time cut has been established. Results: This review had 14 articles on the chosen topic. Conclusions: About Se supplementation, when performed for 24 months significantly reduces the rate of decline in CD4+ cell counts in patients who have not undergone antiretroviral therapy. As for glutamine supplementation, its offer seems to increase the immune response against infections and suppress the expression of cytokines, which reduces inflammatory reactions. In addition, pretreatment with glutamine could cause a more balanced T cell polarization, which would alleviate the inflammatory response and attenuate polymicrobial sepsis-induced lesions.
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