Clinical manifestations, comorbidities, and therapeutic approaches of celiac disease in pediatrics: A systematic review

Abstract

Objective: The general objective of the present study is to analyze the scientific production on Celiac Disease, seeking to identify the main clinical manifestations, as well as the main comorbidities and the main methods used in the treatment of this pathology. Methodology: It is a systematic review focused on understanding the main aspects of Celiac Disease. The research was guided by the question: "What are the clinical manifestations, associated diseases and management of celiac disease in pediatric patients, based on the evidence available in the scientific literature?". To find answers, searches were performed in the PubMed database using three descriptors combined with the Boolean term "AND". This resulted in 268 articles. 17 articles were selected to compose the collection. Results: Celiac Disease (CD) is an immune-mediated condition that affects the gastrointestinal tract and can cause several symptoms, including extraintestinal manifestations. Diagnosis involves serological testing and biopsies, with gluten removal being the only effective treatment. Strict adherence to the gluten-free diet is crucial for recovery, but it can vary between patients, impacting long-term health. Conclusion: CD is associated with other autoimmune and genetic conditions, requiring regular monitoring and ongoing support to ensure the well-being of patients.