THE ARABIAN HORSE OF THE CRABBET LINEAGE AND CEREBELLAR ABIOTROPHY: A LITERATURE REVIEW
DOI:
https://doi.org/10.56238/ERR01v10n4-050Keywords:
Cerebellar Abiotrophy, Arabian Horse, Genetic DiseaseAbstract
Cerebellar abiotrophy (CA) is a hereditary neurodegenerative disease with autosomal recessive inheritance that predominantly affects Arabian horses, with a notable predisposition in the influential Crabbet line. The condition is characterized by early degeneration of Purkinje cells in the cerebellum, resulting in debilitating clinical signs such as ataxia, head tremors, lack of coordination, and imbalance, which manifest in foals up to six months of age. The etiology is associated with a mutation in the MUTYH gene, which impairs DNA repair mechanisms and promotes neuronal oxidative stress. Definitive diagnosis is made through genetic testing or post-mortem histopathological examination, and the disease is incurable. Management focuses on prevention through genetic testing and rigorous reproductive control to avoid crossbreeding between carriers, thus mitigating the significant economic and ethical impacts for breeders. This study reviews the pathophysiological, clinical, and genetic aspects of CA, emphasizing the importance of responsible genetic management in preserving the health and zootechnical value of the Arabian horse.
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