A REVIEW OF NINE MEDICINAL PLANTS FROM THE RENISUS LIST WITH POTENTIAL USE IN DENTISTRY
DOI:
https://doi.org/10.56238/arev7n11-146Keywords:
Medicinal Plants, Dentistry, Phytotherapy, Oral HealthAbstract
This study gathers scientific evidence on the effectiveness of using nine medicinal plants from the RENISUS list in the treatment of oral conditions, highlighting their bioactive compounds and phytocomplexes, with the aim of supporting therapeutic protocols and serving as a reference tool for dental professionals. A bibliographic survey was conducted in the Scielo, PubMed, and Google Scholar databases, using the English and Portuguese descriptors: "Medicinal plants," "dentistry," "phytotherapy," and "oral health," combined using the Boolean operator "AND." The plants studied were: andiroba, copaiba, cat's claw, ginger, aloe vera, garlic, chamomile, turmeric, and clove. The main biological activities described, which justify their use, include anti-inflammatory, antibacterial, antiseptic, healing, analgesic, and antifungal actions.
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AHMAD, N. et al. A novel nanoformulation development of eugenol and their treatment in inflammation and periodontitis. Saudi Pharmaceutical Journal, v. 27, n. 6, p. 778–790, 2019. DOI: https://doi.org/10.1016/j.jsps.2019.04.014
ALMEIDA, G. D.; GODOI, E. P.; SANTOS, E. C.; LIMA, L. R. P. D.; OLIVEIRA, M. E. D. Extrato aquoso de Allium sativum potencializa a ação dos antibióticos vancomicina, gentamicina e tetraciclina frente Staphylococcus aureus. Revista de Ciências Farmacêuticas Básica e Aplicada, Araraquara, v. 34, n. 4, p. 487–492, 2013.
AMANPOUR, S. et al. A systematic review of medicinal plants and herbal products’ effectiveness in oral health and dental cure with health promotion approach. Journal of Education and Health Promotion, v. 12, p. 306, 2023. DOI: https://doi.org/10.4103/jehp.jehp_1297_22
APOLINÁRIO, A. C.; MONTEIRO, M. M. O.; PACHÚ, C. O. Allium sativum como agente terapêutico para diversas patologias: uma revisão. Revista de Biologia e Farmácia, v. 3, n. 1, 2008.
ARAGÃO, E. M. Propriedades físico-químicas e fitoquímicas da Aloe vera (Aloe barbadensis) e da Sucupira (Pterodon pubescens Benth) e aplicações terapêuticas. Morrinhos: Instituto Federal Goiano, 2024. 60 p.
BABAEE, N. et al. Evaluation of the therapeutic effects of Aloe vera gel on minor recurrent aphthous stomatitis. Dental Research Journal, v. 9, n. 4, p. 381–385, 2012.
BARDAJÍ, D. K. R. et al. Copaifera reticulata oleoresin: chemical characterization and antibacterial properties against oral pathogens. Anaerobe, v. 40, p. 18–27, 2016. DOI: https://doi.org/10.1016/j.anaerobe.2016.04.017
BRASIL. Ministério da Saúde. Ação 20K5 (DAF/SCTIE/MS)/2013 – Monografia da espécie Matricaria chamomilla L. (Chamomilla recutita (L.) Rauschert, Camomila). Brasília, 2015.
BRASIL. Ministério da Saúde. Informações Sistematizadas da Relação Nacional de Plantas Medicinais de Interesse ao SUS: Curcuma longa L., Zingiberaceae – Açafrão-da-terra. Brasília: Ministério da Saúde, 2020. 182 p.
BRASIL. Ministério da Saúde; Agência Nacional de Vigilância Sanitária (Anvisa). Monografia da espécie Allium sativum (alho). Brasília, 2015.
BRASIL. Ministério da Saúde; Agência Nacional de Vigilância Sanitária (Anvisa). Monografia da espécie Matricaria chamomilla L. (Chamomilla recutita (L.) Rauschert, Camomila). Brasília: Ministério da Saúde, 2015.
BRASIL. Presidência da República. Decreto nº 5813 de 22 de junho de 2006 – Aprova a Política Nacional de Plantas Medicinais e Fitoterápicos e dá outras providências. Brasília, 2006.
BURIAN, J. P.; SACRAMENTO, L. V. S.; CARLOS, I. Z. Fungal control by garlic extracts (Allium sativum L.) and modulation of peritoneal macrophages activity in murine model of sporotrichosis. Brazilian Journal of Biology, v. 77, n. 4, p. 848–855, 2017. DOI: https://doi.org/10.1590/1519-6984.03716
CAETANO, G. M.; GARCIA, G. A.; GONÇALVES, T. B.; SILVA, J. L. M. Atividade antifúngica do alho (Allium sativum) sobre Candida albicans. Revista Brasileira Multidisciplinar, v. 24, n. 1, p. 112–126, 2021. DOI: https://doi.org/10.25061/2527-2675/ReBraM/2021.v24i1.731
CALDAS, N. L. et al. Cytotoxicity and antimicrobial and physicochemical properties of sealers incorporated with Uncaria tomentosa. Brazilian Oral Research, v. 35, e086, 2021.
CALDAS, N. L.; PRADO, M. C.; CARVALHO, N. K.; SENNA, P. M.; SILVA, E. J. N. L. Cytotoxicity, antimicrobial and physicochemical properties of sealers incorporated with Uncaria tomentosa. Brazilian Oral Research, v. 35, e086, 2021. DOI: https://doi.org/10.1590/1807-3107bor-2021.vol35.0086
CALVI, R. L.; RABI, L. T.; VIANNA, W. O. Práticas integrativas e complementares em saúde (PICS) e a implementação no Sistema Único de Saúde (SUS) – uma breve revisão. Brazilian Journal of Health Review, Curitiba, v. 4, n. 6, p. 29144–29155, 2021. DOI: https://doi.org/10.34119/bjhrv4n6-444
CANDIDO, G. L. A. et al. Capacidade terapêutica da fitoterapia na odontologia: uma análise abrangente das propriedades antimicrobianas, anti-inflamatórias e reparadoras. International Journal of Scientific Dentistry, v. 1, n. 66, p. 84–103, 2025. DOI: https://doi.org/10.22409/ijosd.v1i66.60934
CHOI, S.; CHUNG, M. H. Review on the relationship between Aloe vera components and their biologic effects. Seminars in Integrative Medicine, v. 1, n. 1, p. 53–62, 2003. DOI: https://doi.org/10.1016/S1543-1150(03)00005-X
CONDE, N. C. O. et al. In vitro antimicrobial activity of plants of the Amazon on oral micro-organisms. Revista Odonto Ciência, v. 30, n. 4, p. 179–183, 2015. DOI: https://doi.org/10.15448/1980-6523.2015.4.17794
COSTA, A. T. A. et al. Babosa (Aloe vera) e camomila (Matricaria chamomilla) no tratamento da estomatite aftosa recorrente. Archives of Health Investigation, v. 8, n. 11, p. 751–755, 2019. DOI: https://doi.org/10.21270/archi.v8i11.4661
DAGNE, E.; BISRAT, D.; VILJOEN, A.; VAN WYK, B. E. Chemistry of Aloe species. Current Organic Chemistry, v. 4, n. 10, p. 1055–1078, 2000. DOI: https://doi.org/10.2174/1385272003375932
DAI, C. et al. The natural product curcumin as an antibacterial agent: current achievements and problems. Antioxidants, v. 11, n. 3, p. 459, 2022. DOI: https://doi.org/10.3390/antiox11030459
DANIEL, A. N. et al. Anti-inflammatory and antinociceptive activities of eugenol essential oil in experimental animal models. Revista Brasileira de Farmacognosia, v. 19, n. 1B, p. 212–217, 2009. DOI: https://doi.org/10.1590/S0102-695X2009000200006
DAS, A. D.; BALAN, A.; SREELATHA, K. Comparative study of the efficacy of curcumin and turmeric oil as chemopreventive agents in oral submucous fibrosis: a clinical and histopathological evaluation. Journal of Indian Academy of Oral Medicine and Radiology, v. 22, n. 2, p. 88–92, 2010. DOI: https://doi.org/10.4103/0972-1363.166922
DI SALLE, A. et al. Antimicrobial and antibiofilm activity of curcumin-loaded electrospun nanofibers for the prevention of biofilm-associated infections. Molecules, v. 26, n. 16, p. 4866, 2021. DOI: https://doi.org/10.3390/molecules26164866
FELDBERG, R. S. et al. In vitro mechanism of inhibition of bacterial cell growth by allicin. Antimicrobial Agents and Chemotherapy, v. 32, p. 1763–1768, 1988. DOI: https://doi.org/10.1128/AAC.32.12.1763
FERREIRA, A. S. et al. Natural products for the prevention and treatment of oral mucositis – a review. International Journal of Molecular Sciences, v. 23, n. 8, p. 4385, 2022. DOI: https://doi.org/10.3390/ijms23084385
FLORA DO BRASIL. Uncaria in Flora e Funga do Brasil. Jardim Botânico do Rio de Janeiro, 2025.
FONSECA, G. M. et al. Avaliação da atividade antimicrobiana do alho (Allium sativum Liliaceae) e de seu extrato aquoso. Revista Brasileira de Plantas Medicinais, v. 16, n. 3, p. 679–684, 2014. DOI: https://doi.org/10.1590/1983-084X/12_150
FRAZÃO, D. R. et al. Evaluation of the biological activities of Copaiba (Copaifera spp.): a comprehensive review based on scientometric analysis. Frontiers in Pharmacology, v. 14, p. 1215437, 2023. DOI: https://doi.org/10.3389/fphar.2023.1215437
GENEVA,WORLD HEALTH ORGANIZATION (WHO). Regulatory Situation of Herbal Medicines: A Worldwide Review,1998.
GETTI, G. T. M.; POOLE, P. L. Allicin causes fragmentation of the peptidoglycan coat in Staphylococcus aureus by effecting synthesis and aiding hydrolysis: a determination by MALDI-TOF mass spectrometry on whole cells. Journal of Medical Microbiology, v. 68, p. 667–677, 2019. DOI: https://doi.org/10.1099/jmm.0.000950
GILBERT, B.; ALVES, L. F.; FAVORETO, R. F. Monografias de plantas medicinais brasileiras e aclimatadas. v. II. Rio de Janeiro: Abifisa; Editora Fiocruz, 2022.
GILBERT, B.; ALVES, L. F.; FAVORETO, R. F. Monografias de plantas medicinais brasileiras e aclimatadas. v. II. Rio de Janeiro: Abifisa; Editora Fiocruz, 2022. DOI: https://doi.org/10.7476/9786557081778
GOES, P. et al. Clinical efficacy of a 1% Matricaria chamomilla L. mouthwash and 0.12% chlorhexidine for gingivitis control in patients undergoing orthodontic treatment with fixed appliances. Journal of Oral Science, v. 58, n. 4, p. 569–574, 2016. DOI: https://doi.org/10.2334/josnusd.16-0280
GOMES, M. S.; MENDONÇA, A. K. P.; CORDEIRO, T. O.; OLIVEIRA, M. M. B. Uso de plantas medicinais na odontologia: uma revisão integrativa. Revista Ciências da Saúde Nova Esperança, v. 18, n. 2, p. 118–126, 2020. DOI: https://doi.org/10.17695/revcsnevol18n2p118-126
HALDER, S. et al. Herbal drugs and natural bioactive products as potential therapeutics: a review on pro-cognitives and brain boosters perspectives. Saudi Pharmaceutical Journal, v. 29, n. 8, p. 879–907, 2021. DOI: https://doi.org/10.1016/j.jsps.2021.07.003
HANS, V. M. et al. Antimicrobial efficacy of various essential oils at varying concentrations against periopathogen Porphyromonas gingivalis. Journal of Clinical and Diagnostic Research, v. 10, n. 9, p. ZC16–ZC19, 2016. DOI: https://doi.org/10.7860/JCDR/2016/18956.8435
HARLEV, E. et al. Anticancer potential of aloes: antioxidant, antiproliferative, and immunostimulatory attributes. Phytotherapy Research, v. 78, n. 9, p. 843–852, 2012. DOI: https://doi.org/10.1055/s-0031-1298453
HENRIQUES, M. G.; PENIDO, C. The therapeutic properties of Carapa guianensis. Current Pharmaceutical Design, v. 6, p. 850–856, 2014. DOI: https://doi.org/10.2174/13816128113199990048
HERRERA, D. R. et al. Antimicrobial activity and substantivity of Uncaria tomentosa in infected root canal dentin. Brazilian Oral Research, v. 30, n. 1, 2016.
HERRERA, D. R.; DURAND-RAMIREZ, J. E.; FALCÃO, A.; SILVA, E. J. N. L.; SANTOS, E. B.; GOMES, B. P. F. A. Antimicrobial activity and substantivity of Uncaria tomentosa in infected root canal dentin. Brazilian Oral Research, v. 30, n. 1, 2016. DOI: https://doi.org/10.1590/1807-3107BOR-2016.vol30.0061
JEONG, G. S. et al. Anti-inflammatory effects of apigenin on nicotine- and lipopolysaccharide-stimulated human periodontal ligament cells via heme oxygenase-1. International Immunopharmacology, v. 9, n. 12, p. 1374–1380, 2009. DOI: https://doi.org/10.1016/j.intimp.2009.08.015
JETTANACHEAWCHANKIT, S. et al. Acemannan stimulates gingival fibroblast proliferation; expressions of keratinocyte growth factor-1, vascular endothelial growth factor, and type I collagen; and wound healing. Journal of Pharmacological Sciences, v. 109, n. 4, p. 525–531, 2009. DOI: https://doi.org/10.1254/jphs.08204FP
KAUR, S.; BAINS, K. Aloe barbadensis Miller (Aloe vera): pharmacological activities and clinical evidence for disease prevention. International Journal of Vitamin and Nutrition Research, v. 94, n. 3–4, p. 308–321, 2024. DOI: https://doi.org/10.1024/0300-9831/a000797
LEE, K. H. et al. Essential oil of Curcuma longa inhibits Streptococcus mutans biofilm formation. Journal of Food Science, v. 76, n. 9, p. H226–H230, 2011. DOI: https://doi.org/10.1111/j.1750-3841.2011.02427.x
LI, W. R. et al. Antifungal activity, kinetics and molecular mechanism of action of garlic oil against Candida albicans. Scientific Reports, v. 7, n. 6, p. 22805, 2016. DOI: https://doi.org/10.1038/srep22805
LOI, V. V. et al. Staphylococcus aureus responds to allicin by global S-thioallylation—role of the Brx/BSH/YpdA pathway and the disulfide reductase MerA to overcome allicin stress. Free Radical Biology and Medicine, v. 139, p. 55–69, 2019. DOI: https://doi.org/10.1016/j.freeradbiomed.2019.05.018
MALI, A. M.; BEHAL, R.; GILDA, S. S. Comparative evaluation of 0.1% turmeric mouthwash with 0.2% chlorhexidine gluconate in prevention of plaque and gingivitis: a clinical and microbiological study. Journal of Indian Society of Periodontology, v. 16, n. 3, p. 386–391, 2012. DOI: https://doi.org/10.4103/0972-124X.100917
MARKOWITZ, K.; MOYNIHAN, M.; LIU, M.; KIM, S. Biologic properties of eugenol and zinc oxide–eugenol: a clinically oriented review. Oral Surgery, Oral Medicine, Oral Pathology, v. 73, n. 6, p. 729–737, 1992. DOI: https://doi.org/10.1016/0030-4220(92)90020-Q
MILHOMEM-PAIXÃO, S. S. R. et al. The lipidome, genotoxicity, hematotoxicity and antioxidant properties of andiroba oil from the Brazilian Amazon. Genetics and Molecular Biology, v. 39, n. 2, p. 248–256, 2016. DOI: https://doi.org/10.1590/1678-4685-gmb-2015-0098
MISIR, J.; FATEMA, H.; BRISHTI, M.; HOQUE, M. Aloe vera gel as a novel edible coating for fresh fruits: a review. American Journal of Food Science and Technology, v. 2, n. 3, p. 93–97, 2014. DOI: https://doi.org/10.12691/ajfst-2-3-3
NAIDU, S.; SURESH, A. Effects of turmeric (Curcuma longa) in dentistry. International Journal of Development Research, v. 8, n. 7, p. 21828–21831, 2018.
NAKAMOTO, M.; KUNIMURA, K.; SUZUKI, J. I.; KODERA, Y. Antimicrobial properties of hydrophobic compounds in garlic: allicin, vinyldithiin, ajoene and diallyl polysulfides. Experimental and Therapeutic Medicine, v. 19, n. 2, p. 1550–1553, 2020. DOI: https://doi.org/10.3892/etm.2019.8388
NETO, I. R. C. et al. Uso medicinal da Carapa guianensis (andiroba): uma revisão integrativa. São José dos Pinhais Journal of Health Sciences, v. 6, n. 4, p. 16255–16265, 2024. DOI: https://doi.org/10.56238/arev6n4-305
ODO, E. O. et al. Analysis of the antibacterial effects of turmeric on particular bacteria. Medicine (Baltimore), v. 102, n. 48, e36492, 2023. DOI: https://doi.org/10.1097/MD.0000000000036492
OLIVEIRA, I. S. S. et al. Carapa guianensis Aublet (Andiroba) seed oil: chemical composition and antileishmanial activity of limonoid-rich fractions. BioMed Research International, v. 2018, p. 5032816, 2018. DOI: https://doi.org/10.1155/2018/5032816
PAOLETTI, T. et al. Anti-inflammatory and vascular protective properties of 8-prenylapigenin. European Journal of Pharmacology, v. 620, n. 1–3, p. 120–130, 2009. DOI: https://doi.org/10.1016/j.ejphar.2009.08.015
PAULI, S. et al. Effects of clove (Caryophyllus aromaticus L.) on the labeling of blood constituents with technetium-99m and on the morphology of red blood cells. Brazilian Archives of Biology and Technology, v. 50, suplemento, p. 175–182, 2007. DOI: https://doi.org/10.1590/S1516-89132007000600022
PIERI, F. A.; MUSSI, M. C.; MOREIRA, M. A. S. Óleo de copaíba (Copaifera sp.): histórico, extração, aplicações industriais e propriedades medicinais. Revista Brasileira de Plantas Medicinais, v. 11, n. 4, p. 465–472, 2009. DOI: https://doi.org/10.1590/S1516-05722009000400016
PULIKOTTIL, S. J.; NATH, S. Potential of clove (Syzygium aromaticum) in development of a therapeutic agent for periodontal disease: a review. South African Dental Journal, v. 70, n. 3, p. 108–115, 2015.
RAO, S. et al. The Indian spice turmeric delays and mitigates radiation-induced oral mucositis in patients undergoing treatment for head and neck cancer: an investigational study. Integrative Cancer Therapies, v. 13, n. 3, p. 201–210, 2014. DOI: https://doi.org/10.1177/1534735413503549
RAYATI F, HAJMANOUCHEHRI F, NAJAFI E. Comparison of anti-inflammatory and analgesic effects of Ginger powder and Ibuprofen in postsurgical pain model: A randomized, double-blind, case-control clinical trial. Dent Res J (Isfahan), v. 14, n. 1 ,p. 1.2017.
RAYATI, F.; HAJMANOUCHEHRI, F.; NAJAFI, E. Comparison of anti-inflammatory and analgesic effects of ginger powder and ibuprofen in postsurgical pain model: a randomized, double-blind, case-control clinical trial. Dental Research Journal (Isfahan), v. 14, n. 1, p. 1–7, 2017. DOI: https://doi.org/10.4103/1735-3327.201135
REIZNAUTT, C. M. et al. Development and properties of endodontic resin sealers with natural oils. Journal of Dentistry, v. 104, p. 103538, 2021. DOI: https://doi.org/10.1016/j.jdent.2020.103538
REZENDE, H. A.; COCCO, M. I. M. A utilização de fitoterapia no cotidiano de uma população rural. Revista da Escola de Enfermagem da USP, São Paulo, v. 36, n. 3, p. 282–288, 2002. DOI: https://doi.org/10.1590/S0080-62342002000300011
RODRIGUES, M. M.; SANTOS, S. S. F.; CLARO, C. A. A.; SCHERMA, A. P. Avaliação in vitro da atividade antifúngica do Allium sativum sobre cepas de Candida albicans isoladas de cavidade bucal. Revista de Periodontia, São Paulo, v. 19, n. 2, p. 124–132, 2009.
SANTA MARIA, A. et al. Evaluation of the toxicity of Uncaria tomentosa by bioassays in vitro. Journal of Ethnopharmacology, v. 57, n. 3, p. 183–187, 1997. DOI: https://doi.org/10.1016/S0378-8741(97)00067-6
SANTOS, J. P. C. Fitoterapia como alternativa a métodos tradicionais de tratamento da mucosite oral: revisão de literatura. 2023. 50 f. Trabalho de Conclusão de Curso (Graduação em Odontologia) – Faculdade de Odontologia, Universidade Estadual Paulista (UNESP), Araraquara, 2023.
SANTOS, J.P.C. Fitoterapia como alternativa a métodos tradicionais de tratamento da mucosite oral: revisão de literatura. 2023. 50 f. Monografia(trabalho de conclusão de curso)-Faculdade de Odontologia Universidade Estadual Paulista (Unesp), Araraquara, 2023.
SILVA, V. P.; BRITO, L. C.; MARQUES, A. M.; CAMILO, F. C.; FIGUEIREDO, M. R. Bioactive limonoids from Carapa guianensis seeds oil and the sustainable use of its by-products. Current Research in Toxicology, v. 4, p. 100104, 2023. DOI: https://doi.org/10.1016/j.crtox.2023.100104
SINGH, V. et al. Turmeric – a new treatment option for lichen planus: a pilot study. National Journal of Maxillofacial Surgery, v. 4, n. 2, p. 198–201, 2013. DOI: https://doi.org/10.4103/0975-5950.127651
SOARES, A. S. et al. Therapeutic effects of andiroba (Carapa guianensis Aubl.) oil, compared to low-power laser, on oral mucositis in children undergoing chemotherapy: a clinical study. Journal of Ethnopharmacology, v. 264, p. 113365, 2021. DOI: https://doi.org/10.1016/j.jep.2020.113365
SOUZA, A. B. et al. Antimicrobial evaluation of diterpenes from Copaifera langsdorffii oleoresin against periodontal anaerobic bacteria. Molecules, v. 16, n. 11, p. 9611, 2011. DOI: https://doi.org/10.3390/molecules16119611
SOUZA, T. J. D. et al. O uso de plantas medicinais em infecções bucais: uma alternativa eficaz. Research, Society and Development, v. 13, n. 4, p. 1–7, 2021.
SOUZA, T. J. D. et al. O uso de plantas medicinais em infecções bucais: uma alternativa eficaz. Research, Society and Development, v. 13, n. 4, p. 1–7, 2021. DOI: https://doi.org/10.25248/reas.e6880b.2021
SUHAG, A.; DIXIT, J.; DHAN, P. Role of curcumin as a subgingival irrigant: a pilot study. Periodontal Practice Today, v. 4, 2007.
SURJUSHE, A.; VASANI, R.; SAPLE, D. G. Aloe vera: a short review. Indian Journal of Dermatology, v. 53, n. 4, p. 163–166, 2008. DOI: https://doi.org/10.4103/0019-5154.44785
TAY, L. Y. et al. Evaluation of different treatment methods against denture stomatitis: a randomized clinical study. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, v. 118, n. 1, p. 72–77, 2014.
TAY, L. Y. et al. Evaluation of different treatment methods against denture stomatitis: a randomized clinical study. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, v. 118, n. 1, p. 72–77, 2014. DOI: https://doi.org/10.1016/j.oooo.2014.03.017
TOBOUTI, P. L. et al. Antimicrobial activity of copaiba oil: a review and a call for further research. Biomedicine & Pharmacotherapy, v. 94, p. 93–99, 2017. DOI: https://doi.org/10.1016/j.biopha.2017.07.092
TYAGI, P. et al. Bactericidal activity of curcumin I is associated with damaging of bacterial membrane. PLoS One, v. 10, n. 3, e0121313, 2015. DOI: https://doi.org/10.1371/journal.pone.0121313
VALADAS, L. A. R. et al. Clinical and antimicrobial evaluation of Copaifera langsdorffii Desf. dental varnish in children: a clinical study. Evidence-Based Complementary and Alternative Medicine, v. 2021, p. 6647849, 2021. DOI: https://doi.org/10.1155/2021/6647849
VALERA, M. C. et al. In vitro antimicrobial and anti-endotoxin action of Zingiber officinale as auxiliary chemical and medicament combined to calcium hydroxide and chlorhexidine. Acta Odontologica Scandinavica, v. 73, n. 7, p. 556–561, 2015.
VALERA, M. C. et al. In vitro antimicrobial and anti-endotoxin action of Zingiber officinale as auxiliary chemical and medicament combined to calcium hydroxide and chlorhexidine. Acta Odontologica Scandinavica, v. 73, n. 7, p. 556–561, 2015. DOI: https://doi.org/10.3109/00016357.2014.949846
WALLOCK-RICHARDS, D.; DOHERTY, C. J.; DOHERTY, L.; CLARKE, D. J.; PLACE, M.; GOVAN, J. R.; CAMPOPIANO, D. J. Garlic revisited: antimicrobial activity of allicin-containing garlic extracts against Burkholderia cepacia complex. PLoS One, v. 9, e112726, 2014. DOI: https://doi.org/10.1371/journal.pone.0112726
WANZELER, A. M. V. et al. Therapeutic effect of andiroba oil (Carapa guianensis Aubl.) against oral mucositis: an experimental study in golden Syrian hamsters. Clinical Oral Investigations, v. 5, p. 2069–2079, 2018. DOI: https://doi.org/10.1007/s00784-017-2300-2
WEBER, N. D. et al. In vitro virucidal effects of Allium sativum (garlic) extract and compounds. Planta Medica, v. 58, p. 417–423, 1992. DOI: https://doi.org/10.1055/s-2006-961504
WU, X.; SANTOS, R. R.; FINK-GREMMELS, J. Analyzing the antibacterial effects of food ingredients: model experiments with allicin and garlic extracts on biofilm formation and viability of Staphylococcus epidermidis. Food Science & Nutrition, v. 3, n. 2, p. 158–168, 2015. DOI: https://doi.org/10.1002/fsn3.199
ZARI, A. et al. Treatment with Uncaria tomentosa promotes apoptosis in B16-BL6 mouse melanoma cells and inhibits the growth of B16-BL6 tumours. Molecules, v. 26, n. 4, p. 1066, 2021. DOI: https://doi.org/10.3390/molecules26041066
