THE TUMOR SUPPRESSOR GENE p53 AND ITS ROLE IN THE ETIOPATHOGENESIS OF NEOPLASMS
DOI:
https://doi.org/10.56238/arev7n10-286Keywords:
p53 Gene, Neoplasms, PathologyAbstract
The p53 gene is considered the "guardian of the genome", a protein located in the position 1.3 of the short arm of chromosome 17, whose main function maintaining genome stability under normal conditions and also its integrity. The p53 by having the function of preserving genome integrity, assigns a significant role in carcinogenesis, their relationship has been established due to the high rate of mutations found in malignant tumors from different tissues. Its performance in almost all human tumors, directly or indirectly, has been observed in the pathogenesis. When stabilized, p53 is converted into a functional protein due to its translational modifications in response to cellular stress derived from DNA damage, which follows the start of the realization of some functions due to genetic damage, such as particularly in genes that regulate the cell cycle, DNA stability and programmed cell death (apoptosis).
Downloads
References
1. KOIFMAN, Sergio; KOIFMAN, Rosalina Jorge. Incidência e Mortalidade por Câncer. Questões da saúde reprodutiva, p. 227, 1999.
2. GUERRA, Maximiliano Ribeiro et al. Magnitude e variação da carga da mortalidade por câncer no Brasil e Unidades da Federação, 1990 e 2015. Revista Brasilgeira de Epidemiologia, v. 20, p. 102-115, 2017. https://doi.org/10.1590/1980-5497201700050009
3. Andréa B. C. F. Salles, Agnes C. Fett-Conte, A importância do gene p53 na carcinogênese. Rev.bras.hematol.hemoter.,2002,24(2):85-89. https://doi.org/10.1590/S1516-84842002000200004
4. Jones PA, Laird PW. Cancer epigenetics comes of age. Nature Genet, 1999. 21, 163-167. https://doi.org/10.1038/5947
5. Kawamura M. DNA circulante em paciente com câncer. Germinis - Boletim Informativo
6. Lane DP, Crawford LV. T-antigen is bound to host protein in SV40-transformed cells. Nature, 1979. 278: 261-263. https://doi.org/10.1038/278261a0
7. Strachan T, Read AP. Genética Molecular Humana. 2 ed. Porto Alegre: Artmed Editora, 2002. 576p.
8. Weinert T. DNA damage and checkpoint pathways: molecular anatomy and interactions with repair. Cell, 1998. 94: 555- 558. DOI: 10.1016/S0092-8674(00)81597-4
9. Yamaguchi K, Sugano K, Fukayama, et al. Polymerase chain reaction-based approaches for detection of allelic loss in the p53 tumor suppressor gene in colon neoplasms. Am J Gastroenterol, 1997. 92, 307-312.
10. Jorde LB, Carey JC, Bamshad MJ, et al. Genética Médica. 2 ed. Rio de Janeiro: Guanabara-Koogan, 2000. 297p.
11. Bandoh N, Hayashi T, Kishibi K., et al. Prognostic value of p53 mutations, bax, and spontaneous apoptosis in maxillary sinus squamous cell carcinoma. Cancer, 2002. 94:1968-1980. https://doi.org/10.1002/cncr.10388
12. Goloni CBV. Estudo das alterações cariotípicas, do rearranjo gênico BCR/ABL e do cromossomo 20 em leucemias. São José do Rio Preto, 2000. 150p. Dissertação de mestrado – Genética, Instituto de Biociências, Letras e Ciências Exatas, IBILCE-UNESP.
13. GEORGE, Philomena. p53 How crucial is its role in cancer. Int J Curr Pharm Res, v. 3, n. 2, p. 19-25, 2011.
14. MAXIMOV, G.; MAXIMOV, K. The role of p53 tumor-suppressor protein in apoptosis and cancerogenesis. Biotechnology & Biotechnological Equipment, Sófia, v. 22, n. p. 664-668, 2008. https://doi.org/10.1080/13102818.2008.10817532
15. FETT-CONTE, Agnes C.; SALLES, A. B. C. F. A importância do gene p53 na carcinogênese humana. Rev Bras Hematol Hemoter, v. 24, n. 2, p. 85-89, 2002. https://doi.org/10.1590/S1516-84842002000200004
16. GARCIA, Patrick Vianna et al. Increased toll-like receptors and p53 levels regulate apoptosis and angiogenesis in non-muscle invasive bladder cancer: mechanism of action of P-MAPA biological response modifier. BMC cancer, v. 16, n. 1, p. 1, 2016. https://doi.org/10.1186/s12885-016-2474-z
17. BALLESTEROS CASTAÑEDA, Doris et al. Proteína p53: sinais e o papel no processo de carcinogênese. Rev. cir. traumatol. buco-maxilo-fac, v. 7, n. 2, 2008.
18. RIVLIN, Noa et al. Mutations in the p53 tumor suppressor gene important milestones at the various steps of tumorigenesis. Genes & cancer, v. 2, n. 4, p. 466-474, 2011. https://doi.org/10.1177/1947601911408889
19. JÚNIOR, Geraldo Barroso Cavalcanti; KLUMB, Claudete Esteves; MAIA, Raquel C. p53 e as hemopatias malignas. Revista Brasileira de Cancerologia, v. 48, n. 3, p. 419-427, 2002. https://doi.org/10.32635/2176-9745.RBC.2002v48n3.2218
20. Soussi, T., and K. G. Wiman. "TP53: an oncogene in disguise." Cell Death & Differentiation 22.8 (2015): 1239-1249. https://doi.org/10.1038/cdd.2015.53
21. MARTINEZ-ZAPIEN, Denise et al. Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53. Nature, v. 529, n. 7587, p. 541-545, 2016. https://doi.org/10.1038/nature16481
22. BURSAC, Sladana et al. Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, v. 1842, n. 6, p. 817-830, 2014. https://doi.org/10.1016/j.bbadis.2013.08.014
23. GIGLIO, Auro Del et al. Mutaçäo do gene p53 induzindo predisposiçäo genética ao câncer: relato de um caso da síndrome de Li-Fraumeni. Rev. bras. clín. ter, v. 28, n. 6, p. 256-259, 2002.
24. CATANI, João Paulo Portela. Terapia gênica do câncer associando reparo da via p53 à imunoestimulação por IFN β. 2014. Tese de Doutorado. Universidade de São Paulo.
https://doi.org/10.11606/T.5.2014.tde-26112014-100519
25. TAVARES DOS SANTOS, Giovana et al. Fatores clínicos e anatomopatológicos que influenciam a sobrevida de pacientes com câncer de mama e derrame pleural neoplásico. Jornal Brasileiro de Pneumologia, v. 38, n. 4, 2012. https://doi.org/10.1590/S1806-37132012000400011
26. DE QUEIROZ, Rafaela Muniz et al. Changes in O-GlcNAc homeostasis activate the p53 pathway in ovarian cancer cells. Journal of Biological Chemistry, p. jbc. M116. 734533, 2016. https://doi.org/10.1074/jbc.M116.734533
