ANALYSIS OF THE EFFECT OF NANOPARTICLES CONTAINING ΑLFA HUMULENE AND CURCUMIN ON NEUROINFLAMMATION: A SYSTEMATIC REVIEW

Authors

  • Giovanna Tardem Oliveira Author
  • Isabella Cristina Chiamolera Author
  • João Alfredo Schiewe Author
  • Livia Hoyer Garcia Miranda Author
  • Daniele Eurick Author
  • Jaine Alessandra Korchak Alves Author
  • André Alexandre Pezzini Author
  • Ivo Ilvan Kerppers Author

DOI:

https://doi.org/10.56238/arev7n2-237

Keywords:

Beta Amyloid, Humulene, Neuroinflammation, Cytokines, Alzheimer's disease

Abstract

Objective: To analyze the available evidence about nanoparticles containing alpha humulene and curcumin, and their possible therapeutic effects on neuroinflammation. Methodology: Systematic review of the literature, carried out from December 2023 to July 2024, covering publications from 2014 to 2024, in the Cochrane and PubMed electronic databases, based on the following descriptors: "curcumin", "Alzheimer disease", "Alzheimer", "cytokines", "humulene" and "nanoparticles", with the aid of the Boolean operator "AND". Results: A total of 672 articles were found, of which 10 met the inclusion and exclusion criteria. They addressed topics such as inflammatory changes in cerebrospinal fluid and blood, effects of curcumin and alpha-humulene on inflammatory markers, action on ß-amyloid and hyperphosphorylated tau proteins, modulation of insulin resistance, cognitive decline, in addition to the challenges of bioavailability and formulation of compounds, highlighting the relevance for prevention and intervention in Alzheimer's. Discussion: The review identified variables on the effects of α-humulene and curcumin on neuroinflammation and highlighted the need for further studies on their efficacy in Alzheimer's.

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Published

2025-02-20

Issue

Vol. 7 No. 2 (2025)

Section

Articles

How to Cite

OLIVEIRA, Giovanna Tardem; CHIAMOLERA, Isabella Cristina; SCHIEWE, João Alfredo; MIRANDA , Livia Hoyer Garcia; EURICK, Daniele; ALVES , Jaine Alessandra Korchak; PEZZINI, André Alexandre; KERPPERS, Ivo Ilvan. ANALYSIS OF THE EFFECT OF NANOPARTICLES CONTAINING ΑLFA HUMULENE AND CURCUMIN ON NEUROINFLAMMATION: A SYSTEMATIC REVIEW. ARACÊ , [S. l.], v. 7, n. 2, p. 8611–8625, 2025. DOI: 10.56238/arev7n2-237. Disponível em: https://periodicos.newsciencepubl.com/arace/article/view/3461. Acesso em: 5 dec. 2025.