NANOTECHNOLOGY APPLIED TO PHARMACOLOGY: ADVANCES IN THE DEVELOPMENT OF DRUGS FOR PRECISION THERAPIES
DOI:
https://doi.org/10.56238/arev8n5-007Keywords:
Pharmacology, Nanotechnology, Drug Delivery Systems, Precision Therapy, Personalized TreatmentAbstract
Nanotechnology applied to pharmacology has emerged as an innovative strategy in the development of drugs for precision therapies, promoting significant advances in the efficacy, safety, and individualization of treatments. This study aimed to analyze the main advances in nanotechnology in the development of drugs for precision therapies, highlighting its applications, benefits, and challenges. This is a qualitative literature review conducted in the PubMed, Scopus, MEDLINE, and SciELO databases, encompassing studies published between 2022 and 2026, in Portuguese and English. The results showed that nanostructured systems allow for greater selectivity in drug delivery, acting directly on specific molecular targets and reducing systemic adverse effects. Advances in intelligent controlled-release systems, combined therapies, epigenetic nanotechnology, and integration with pharmacogenomics are also highlighted, expanding the possibilities for personalized interventions. Furthermore, the application of nanodevices in diagnostic and therapeutic monitoring has been verified, contributing to greater clinical precision. However, challenges related to safety, toxicity, environmental impact, and regulation persist, still limiting the widespread application of these technologies in clinical practice. It is concluded that nanotechnology represents a milestone in the transformation of contemporary pharmacology, enabling the development of more effective, safe, and individualized therapies. However, it is essential to advance clinical and regulatory research to enable its large-scale implementation, consolidating its role in precision medicine.
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References
ABDOllAHZADEH, H.; PEEPLES, T. L.; SHAHCHERAGHI, M. DNA nanotechnology in oligonucleotide drug delivery systems: prospects for bio-nanorobots in cancer treatment. Advanced Drug Delivery Reviews, v. 225, p. 115673, 2025.
ADEPU, S.; RAMAKRISHNA, S. Controlled drug delivery systems: current status and future directions. Molecules, v. 26, n. 19, p. 5905, 2021.
AHMAD, U. et al. Nanotechnology-driven epigenetic cancer therapy: precision delivery and sustained release of DNA methylation modulators. Yale Journal of Biology and Medicine, v. 98, n. 2, p. 227–235, 2025.
CAI, J. et al. Intelligent nanomedicine systems utilizing diverse nanoparticles for osteosarcoma therapy: a review. International Journal of Nanomedicine, v. 20, p. 14115–14130, 2025.
CHATTOPADHYAY, A. et al. Revolutionizing breast cancer therapeutics: intersecting frontiers of precision medicine, nanotechnology, and drug delivery innovations. Current Treatment Options in Oncology, v. 26, n. 9, p. 775–796, 2025.
CHEN, S. et al. Advance on combination therapy strategies based on biomedical nanotechnology induced ferroptosis for cancer therapeutics. Biomedicine & Pharmacotherapy, v. 176, p. 116904, 2024.
HAN, C. et al. Intelligent systems for inorganic nanomaterial synthesis. Nanomaterials, v. 15, n. 8, p. 631, 2025.
KALLEPALLI, B. et al. Intelligent drug delivery: pioneering stimuli-responsive systems to revolutionize disease management: an in-depth exploration. Current Drug Delivery, v. 22, n. 2, p. 195–214, 2025.
LAI, C. M. et al. Nanotechnology strategies in plant genetic engineering: intelligent delivery and precision editing. Plants, v. 14, n. 23, p. 3625, 2025.
LI, X.; SUN, T.; JIANG, C. Intelligent delivery systems in tumor metabolism regulation: exploring the path ahead. Advanced Materials, v. 36, n. 11, e2309582, 2024.
LÓPEZ-ESTÉVEZ, A. M. et al. Nanotechnology-assisted intracellular delivery of antibody as a precision therapy approach for KRAS-driven tumors. Journal of Controlled Release, v. 373, p. 277–292, 2024.
MA, X. et al. Nanotechnology in healthcare, and its safety and environmental risks. Journal of Nanobiotechnology, v. 22, n. 1, p. 715, 2024.
NINH, T. T. K. et al. Application of computational screening tools and nanotechnology for enhanced drug synergism in cancer therapy. Current Drug Delivery, v. 20, n. 7, p. 1015–1029, 2023.
SMADJA, D. M.; LELLOUCH, A. G. A promising frontier in cancer therapy: combining endothelial colony forming cells, nanotechnology, and hyperthermia for precision oncology. Stem Cell Reviews and Reports, v. 21, n. 8, p. 2343–2347, 2025.
TANTRAY, J. et al. Nanotechnology-based biomedical devices in cancer diagnostics and therapy. Medical Oncology, v. 42, n. 2, p. 50, 2025.
TIWARI, R. et al. Nano-enabled pharmacogenomics: revolutionizing personalized drug therapy. Journal of Biomaterials Science, Polymer Edition, v. 36, n. 7, p. 913–938, 2025.
WANG, J.; ZHAO, Y.; NIE, G. Intelligent nanomaterials for cancer therapy: recent progresses and future possibilities. Medical Review, v. 3, n. 4, p. 321–342, 2023.
YADOLLAHPOUR, A. Nanotechnology and biomarkers in precision medicine: advances and perspectives. Current Topics in Medicinal Chemistry, v. 21, n. 14, p. 1199–1201, 2021.
YANG, C. et al. Nanoplatform-mediated autophagy regulation and combined anti-tumor therapy for resistant tumors. International Journal of Nanomedicine, v. 19, p. 917–944, 2024.
YANG, H. et al. Nanotechnology-targeted modulation of mitophagy in cancer therapy: progress and challenges. Acta Biomaterialia, v. 204, p. 129–155, 2025.
ZAHRA, M.; ABRAHAMSE, H.; GEORGE, B. P. Green nanotech paradigm for enhancing sesquiterpene lactone therapeutics in cancer. Biomedicine & Pharmacotherapy, v. 173, p. 116426, 2024.
