IMPACT OF ELECTRONIC CIGARETTES ON THE ORAL CAVITY: SCOPING REVIEW
DOI:
https://doi.org/10.56238/arev8n4-027Keywords:
Electronic Nicotine Delivery Systems, Vaping, Mouth Neoplasms, Smokers, Mouth MucosaAbstract
Electronic Nicotine Delivery Systems (ENDS) are devices that vaporize a liquid containing nicotine and other potentially toxic substances, such as heavy metals, aldehydes, and carcinogenic compounds. Popular among younger populations, their use has been associated with adverse health effects, particularly in the oral cavity, the first site of contact with aerosols. This study aims to identify conceptual categories and gaps related to the effects of e-cigarettes on the oral cavity. A scoping review was conducted following the Joanna Briggs Institute (JBI) protocol and the PRISMA-ScR checklist. The research question, based on the PEO (Participants, Exposure, Outcome) strategy, investigated the effects of e-cigarette use on oral health. Pilot studies, randomized clinical trials, controlled and non-randomized studies, and case reports were included without restrictions on language or publication date. A total of 68 studies were identified, of which 7 met the inclusion criteria. The results revealed cytotoxic, inflammatory, infectious, and carcinogenic effects associated with e-cigarette use, even in the absence of nicotine. Lesions such as nicotine stomatitis, hairy tongue, and hyperplastic candidiasis were more frequent, along with a higher prevalence of Human Papillomavirus (HPV). Therefore, e-cigarette use may cause significant damage to the oral mucosa, altering its integrity, microbiota, and metabolism, and may contribute to the development of neoplasms. These findings reinforce that e-cigarettes are not a safe alternative to smoking and highlight the need for clinical attention, especially among young users.
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References
Alhajj, M. N., et al. (2022). Oral health practices and self-reported adverse effects of e-cigarette use among dental students in 11 countries: an online survey. BMC Oral Health, 22(1), 1–9. DOI: https://doi.org/10.1186/s12903-022-02053-0
Ali, D., et al. (2022). Comparison of periodontal status and salivary IL-15 and -18 levels in cigarette-smokers and individuals using electronic nicotine delivery systems. BMC Oral Health, 22(1), 1–7. DOI: https://doi.org/10.1186/s12903-022-02700-6
Bardellini, E., et al. (2018). Oral mucosal lesions in electronic cigarettes consumers versus former smokers. Acta Odontologica Scandinavica, 76(3), 226–228. DOI: https://doi.org/10.1080/00016357.2017.1406613
Bustamante, G., et al. (2018). Presence of the carcinogen N′-nitrosonornicotine in saliva of e-cigarette users. Chemical Research in Toxicology, 31(8), 731–738. DOI: https://doi.org/10.1021/acs.chemrestox.8b00089
Cátala-Valentín, A. R., et al. (2022). E-cigarette aerosols promote oral S. aureus colonization by delaying an immune response and bacterial clearing. Cells, 11(5). DOI: https://doi.org/10.3390/cells11050773
De Sousa, A. C. C., et al. (2023). Impactos do uso de cigarro eletrônico na prevalência do câncer bucal: revisão de literatura. Revista de Estudos Multidisciplinares, 1(5), 12–26.
Elmahdi, F. M., et al. (2023). A cytological study of oral human papillomavirus (HPV) infection among electronic cigarette smokers in Al-Madinah Al-Munawara. Cureus. DOI: https://doi.org/10.7759/cureus.40421
Filho, A. R. de S. B., et al. (2021). Cigarro eletrônico: malefícios e comparação com o tabagismo convencional. Brazilian Journal of Health Review, 4(4), 15898–15907. DOI: https://doi.org/10.34119/bjhrv4n4-119
Guo, J., et al. (2021). Liquid chromatography-nanoelectrospray ionization-high-resolution tandem mass spectrometry analysis of apurinic/apyrimidinic sites in oral cell DNA of cigarette smokers, e-cigarette users, and nonsmokers. Chemical Research in Toxicology, 34(12), 2540–2548. DOI: https://doi.org/10.1021/acs.chemrestox.1c00308
Klawinski, D., et al. (2021). Vaping the venom: oral cavity cancer in a young adult with extensive electronic cigarette use. Pediatrics, 147(5), e2020022301. DOI: https://doi.org/10.1542/peds.2020-022301
Machado, B. M. B., et al. (2023). Uso de cigarro eletrônico e os impactos na cavidade oral. Brazilian Journal of Periodontology, 33(2), 16–25. DOI: https://doi.org/10.14436/0103-9393.33.2.16-25.oar
Nguyen, H., et al. (2017). Oral carcinoma associated with chronic use of electronic cigarettes. Otolaryngology (Sunnyvale), 7(2), 304. DOI: https://doi.org/10.4172/2161-119X.1000304
Pandarathodiyil, A. K., et al. (2021). Lactate dehydrogenase levels in the saliva of cigarette and e-cigarette smokers (vapers): a comparative analysis. Asian Pacific Journal of Cancer Prevention, 22(10), 3227–3235. DOI: https://doi.org/10.31557/APJCP.2021.22.10.3227
Silva, B. B. L. da, et al. (2021). Injuries caused by the use of electronic cigarettes: an integrative review. Research, Society and Development, 10(16), e25101623137. DOI: https://doi.org/10.33448/rsd-v10i16.23137