COSMETICS AND ENDOCRINE DISRUPTORS: WHAT IS KNOWN ABOUT THE EARLY ONSET OF PUBERTY
DOI:
https://doi.org/10.56238/arev8n2-059Keywords:
Endocrine Disruptor, Cosmetics, PubertyAbstract
This study aimed to understand the relationship between exposure to endocrine disruptors present in cosmetics and the early onset of puberty in children and adolescents. Precocious puberty has been observed with increasing frequency in recent decades, especially among girls, and is associated with significant physical, emotional, and social consequences. Among the environmental factors involved, endocrine disruptors stand out as chemical substances capable of interfering with the hormonal system, widely present in everyday products such as makeup, creams, shampoos, and sunscreens. Compounds such as phthalates, parabens, bisphenol A, and phenols have been associated with the anticipation of pubertal events, including thelarche and menarche, as well as relevant hormonal alterations. This is an integrative literature review conducted through searches in the PubMed, BVS, and LILACS databases, including articles published in the last ten years in Portuguese, English, and Spanish. A total of 12 primary studies with different methodological designs were analyzed. The results indicated a consistent association between exposure to endocrine disruptors and the early onset of puberty, although the magnitude of the effects varies according to the type of compound, dose, and duration of exposure. It is concluded that, despite existing methodological limitations, the evidence reinforces the need for stricter regulatory policies and for new longitudinal studies to deepen the understanding of this phenomenon and its impacts on child health.
Downloads
References
AIMUZI, Ruxianguli et al. Exposure to phthalates, phenols, and parabens mixture and alterations in sex steroid hormones among adolescents. Chemosphere, v. 302, p. 134834, 2022.
BARROS, Dayane et al. Disruptores endócrinos e sua influência na saúde humana. Brazilian Journal of Development, v. 5, n. 11, p. 24211-24225, 2019.
CORREA, Maria Eduarda Reis et al. Puberdade precoce: fatores que influenciam sua ocorrência. Revista Eletrônica Acervo Científico, v. 36, p. e8754, 2021.
HUYNH, Quynh Thi et al. The relationship between bisphenol A and phthalates with precocious puberty in Vietnamese children. Journal of Pediatric Endocrinology and Metabolism, v. 37, n. 7, p. 644-651, 2024.
HABIB, Yasmin Guerra Saib et al. Impacto da exposição ambiental a disruptores endócrinos na saúde reprodutiva: uma revisão de literatura. Revista Arquivos de Saúde, v. 5, n. 3, p. e2127, 2024.
HU, Peipei et al. Associations between exposure to a mixture of phenols, parabens, and phthalates and sex steroid hormones in children 6–19 years from NHANES, 2013–2016. Science of the Total Environment, v. 822, p. 153548, 2022.
JACOB, Kethelen Konstansky et al. Prevalência de puberdade precoce e fatores ambientais associados. Journal Archives of Health, v. 6, n. 4, p. e2797, 2025.
JUNG, Mo Kyung et al. The analysis of endocrine disruptors in patients with central precocious puberty. BMC Pediatrics, v. 19, n. 1, p. 323, 2019.
KIM, Mi Ra et al. The association between phthalate exposure and pubertal development. European Journal of Pediatrics, v. 183, n. 4, p. 1675-1682, 2024.
KONIECZNA, Aleksandra; RUTKOWSKA, Aleksandra; RACHOŃ, Dorota. Health risk of exposure to Bisphenol A (BPA). Roczniki Państwowego Zakładu Higieny, v. 66, n. 1, 2015.
LI, Haidan et al. Perfluorinated compounds linked to central precocious puberty in girls during COVID-19: an untargeted metabolomics study. Frontiers in Endocrinology, v. 15, p. 1491411, 2024.
MENDONÇA, Kamylly Reina Carneiro; CARDOSO, André Luiz; DA SILVA, Rayana Queiroz. Influência dos desreguladores endócrinos no desenvolvimento puberal: uma revisão integrativa. Brazilian Journal of Health Review, v. 7, n. 5, p. e72880, 2024.
QI, Hongli; PU, Shanshan; ZHAI, Huibin. Clinical characteristics and risk factors of female precocious puberty. Medicine, v. 104, n. 6, p. e41483, 2025.
SRILANCHAKON, Khomsak et al. Higher phthalate concentrations are associated with precocious puberty in normal weight Thai girls. Journal of Pediatric Endocrinology and Metabolism, v. 30, n. 12, p. 1293-1298, 2017.
SOUSA, Vagner Alexandre de et al. Toxicologia dos cosméticos: avaliação dos riscos que os produtos capilares trazem à saúde. Revista Visão Acadêmica, Cajazeiras, v. 20, n. 4, p. 78-93, 2019.
SOUZA, Bianca Melissa Costa; SERRÃO, Carlos Klinger Rodrigues. Desmistificando os parabenos: verdades por trás dos conservantes cosméticos. Brazilian Journal of Implantology and Health Sciences, v. 6, n. 10, p. 4603-4613, 2024.
SUGUIEDA, Erik Heidi Viana; MARAGNO, Matheus Juliano Oliveira; MASCARENHAS, André Neves. A relação entre disruptores endócrinos e a puberdade precoce: uma revisão sistemática de estudos observacionais. Revista Brasileira de Revisão de Saúde, v. 7, n. 4, p. e71466, 2024.
TANG, Jingyi et al. Exposure to synthetic steroid hormones and precocious puberty in girls: A case-control study. Ecotoxicology and Environmental Safety, v. 283, p. 116814, 2024.
ZHANG, Yunhui et al. Could exposure to phthalates speed up or delay pubertal onset and development? A 1.5-year follow-up of a school-based population. Environment International, v. 83, p. 41-49, 2015.
ZUO, Melody et al. The causal role of endocrine disrupting chemicals in pubertal timing: a Mendelian randomization study. Journal of Pediatric Endocrinology and Metabolism, 2025.