THERAPEUTIC POTENTIAL OF USAG-1 INHIBITION FOR HUMAN TOOTH REGENERATION: A NARRATIVE REVIEW
DOI:
https://doi.org/10.56238/arev7n12-227Keywords:
Tooth Regeneration, USAG-1 Antibody, Bone Morphogenetic Proteins (BMP), Tooth DevelopmentAbstract
Objective: This review aimed to summarize current scientific evidence regarding pharmacological induction of human tooth regeneration through inhibition of the USAG-1 pathway.
Methodology: A structured search was performed in PubMed, Web of Science, and Google Scholar using the keywords “tooth regeneration”, “USAG-1”, “BMP signaling”, and “monoclonal antibody”. After removing duplicates, studies were screened by title and abstract. Full-text analysis was conducted to identify research addressing preclinical or clinical trials on USAG-1 inhibition for tooth development.
Results: Experimental evidence in animal models demonstrated that USAG-1 inhibition promotes tooth bud formation by enhancing BMP signaling. Preliminary human trial reports confirmed favorable safety and potential for inducing dental tissue growth, with no significant adverse effects.
Conclusion: Blocking USAG-1 represents a promising therapeutic pathway for biological tooth regeneration. Translating these findings into clinical practice could revolutionize restorative dentistry, offering natural tooth replacement and reducing the dependence on implants and prosthetics.
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References
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