INFLUENCE OF ENDOCRINE DISRUPTORS ON THE DEVELOPMENT OF CRYPTORCHIDISM IN THE PEDIATRIC POPULATION
DOI:
https://doi.org/10.56238/arev7n12-201Keywords:
Endocrine Disruptors, Cryptorchidism, Pediatrics, Microplastics, Water SecurityAbstract
Introduction: The interference of synthetic chemical compounds with the endocrine system has become an increasing concern in public health. Among the most discussed effects is the impact of these endocrine disruptors (EDs) on the development of the male reproductive system. In this context, cryptorchidism has emerged as one of the conditions potentially associated with early exposure to these substances. Objective: To discuss the main endocrine disruptors (EDs) involved in the development of cryptorchidism in male children. Methodology: This is an integrative review based on searches in the PubMed, Medline, and Lilacs databases, using the descriptors “Endocrine Disruptors,” “Pediatrics,” and “Cryptorchidism.” Results: A total of 44 articles were found, of which 12 met the inclusion criteria. Evidence indicates an association between cryptorchidism and exposure to EDs such as phthalates (DEHP, DBP), halogenated and nitrogenated organic compounds, glycol ethers, and their derivatives. Furthermore, recent studies have identified microplastic particles in samples of drinking and river water, as well as in food and human tissues such as blood, liver, lung, brain, and semen. These microplastics may act as vectors for EDs, contributing to reproductive health risks. Conclusions: Exposure to EDs, especially during pregnancy, is a significant risk factor for cryptorchidism, with important implications for public health and water security.
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References
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