ACETATO: MECANISMOS CELULARES E POTENCIAL TERAPÊUTICO EM DOENÇAS NEUROIMUNOLÓGICAS E NEURODEGENERATIVAS
DOI:
https://doi.org/10.56238/levv16n53-008Palavras-chave:
Acetato, Doenças Neurológicas, Glutamato, N-acetilaspartato, Neuroinflamação, NeuroproteçãoResumo
O acetato vem se tornando, ao longo do tempo, de grande relevância para os estudos que envolvem vias metabólicas, principalmente relacionadas à bioenergética e estrutura celular. O acetato, além de ser substrato no ciclo de Krebs, é um importante intermediário para a síntese de lipídeos. No cérebro, o acetato se envolve em etapas enzimáticas importantes para a formação da mielina, processo este, envolvido no tratamento de doenças neurodegenerativas. Ainda, o acetato apresenta grande afinidade por astrócitos e está envolvido na síntese de neurotransmissores. A suplementação oral de acetato ou a dieta acetogênica vêm apresentando importante atividade neuroprotetora, principalmente relacionadas a doenças neuroinflamatórias. O presente trabalho conflui processos metabólicos, bioenergéticos, estruturais e nutricionais e apresenta perspectivas terapêuticas relacionados ao acetato.
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