ACETATO: MECANISMOS CELULARES Y POTENCIAL TERAPÉUTICO EN ENFERMEDADES NEUROINMUNOLÓGICAS Y NEURODEGENERATIVAS
DOI:
https://doi.org/10.56238/levv16n53-008Palabras clave:
Acetato, Enfermedades Neurológicas, Glutamato, N-acetilaspartato, Neuroinflamación, NeuroprotecciónResumen
Con el tiempo, el acetato ha adquirido una importancia creciente en los estudios que involucran vías metabólicas, en particular las relacionadas con la bioenergética y la estructura celular. Además de ser un sustrato en el ciclo de Krebs, el acetato es un intermediario importante para la síntesis de lípidos. En el cerebro, el acetato participa en importantes pasos enzimáticos para la formación de mielina, un proceso implicado en el tratamiento de enfermedades neurodegenerativas. Además, el acetato tiene una alta afinidad por los astrocitos y participa en la síntesis de neurotransmisores. La suplementación oral con acetato o una dieta acetogénica han demostrado una actividad neuroprotectora significativa, particularmente en enfermedades neuroinflamatorias. Este estudio aborda los procesos metabólicos, bioenergéticos, estructurales y nutricionales, y presenta perspectivas terapéuticas relacionadas con el acetato.
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