IMPACTO DEL CANNABIDIOL EN LA REGENERACIÓN ÓSEA GUIADA: IMPLICACIONES PARA LA IMPLANTODONCIA MODERNA
DOI:
https://doi.org/10.56238/levv16n52-046Palabras clave:
Cannabidiol, Regeneración Ósea Guiada, Implantología, Osteogénesis, BiomaterialesResumen
La regeneración ósea guiada (ROG) es una técnica ampliamente utilizada en implantología dental para restaurar la cantidad y calidad ósea en zonas deficientes, con el objetivo de garantizar el éxito de los implantes dentales. En los últimos años, el cannabidiol (CBD), un fitocannabinoide de Cannabis sativa, ha demostrado prometedoras propiedades terapéuticas en procesos regenerativos gracias a su acción moduladora de la inflamación, la osteogénesis y la remodelación ósea. Este artículo realizó una revisión bibliográfica de estudios experimentales y clínicos relacionados con el efecto del CBD en la regeneración ósea, analizando sus mecanismos de acción, seguridad, eficacia y posibles aplicaciones en implantología dental. Los hallazgos indican que el CBD promueve la diferenciación de osteoblastos, inhibe la actividad de los osteoclastos, reduce la inflamación y favorece la integración del injerto óseo, proporcionando un entorno favorable para la cicatrización y el éxito del implante. Si bien los resultados son prometedores, se necesitan estudios clínicos controlados para establecer protocolos terapéuticos estandarizados y definir dosis seguras. La incorporación del CBD a la ROG representa una perspectiva innovadora para los tratamientos regenerativos personalizados, contribuyendo a avances significativos en la implantología dental moderna.
Descargas
Referencias
ABIDI, A.H. et al. Cannabinoid type-2 receptor agonist, inverse agonist, and anandamide regulation of inflammatory responses in IL-1β stimulated primary human periodontal ligament fibroblasts. Journal of Periodontal Research, v. 55, p. 762–783, 2020. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32562275/. Acesso em: 15 ago. 2025.
BERNARDINI, S. et al. Natural products for human health: an historical overview of the drug discovery approaches. Natural Product Research, v. 32, p. 1926–1950, 2018. Disponível em: https://pubmed.ncbi.nlm.nih.gov/28748726/. Acesso em: 15 ago. 2025.
PubMed
CARMONA RENDÓN, Y. et al. Cannabinoids in Periodontology: Where Are We Now? Antibiotics, v. 12, p. 1687, 2023. Disponível em: https://pubmed.ncbi.nlm.nih.gov/38136721/. Acesso em: 15 ago. 2025.
PubMed
GU, Z. et al. Marijuana-Derived Cannabinoids Trigger a CB2/PI3K Axis of Suppression of the Innate Response to Oral Pathogens. Frontiers in Immunology, v. 10, p. 2288, 2019. Disponível em: https://pmc.ncbi.nlm.nih.gov/articles/PMC6804395/. Acesso em: 15 ago. 2025.
PubMed Central
JIRÁSEK, P. et al. Cannabidiol and periodontal inflammatory disease: a critical assessment. Biomedicines, v. 166, p. 155–160, 2022. Disponível em: https://pubmed.ncbi.nlm.nih.gov/35332345/. Acesso em: 15 ago. 2025.
KLEIN, M. et al. Effects of cannabidiol, a Cannabis sativa constituent, on oral wound healing process in rats: clinical and histological evaluation. Phytotherapy Research, v. 32, p. 2275–2281, 2018. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30088305/. Acesso em: 15 ago. 2025.
PubMed
KONERMANN, A. et al. In vivo and in vitro identification of endocannabinoid signaling in periodontal tissues and their potential role in local pathophysiology. Cellular and Molecular Neurobiology, v. 37, p. 1511–1520, 2017. Disponível em: https://pubmed.ncbi.nlm.nih.gov/28289947/. Acesso em: 15 ago. 2025.
KOTURBASH, I.; MACKAY, D. Cannabidiol and other cannabinoids: from toxicology and pharmacology to the development of a regulatory pathway. Journal of Dietary Supplements, v. 17, p. 1–20, 2020. Disponível em: https://www.tandfonline.com/doi/full/10.1080/19390211.2020.1796886. Acesso em: 15 ago. 2025.
Taylor & Francis Online +1
KOZONO, S. et al. Involvement of the endocannabinoid system in periodontal healing. Biochemical and Biophysical Research Communications, v. 394, p. 928–933, 2010. Disponível em: https://pubmed.ncbi.nlm.nih.gov/20452402/. Acesso em: 15 ago. 2025.
LIU, C. et al. Activation of cannabinoid receptors promote periodontal cell adhesion and migration. Journal of Clinical Periodontology, v. 46, p. 1264–1272, 2019. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31386606/. Acesso em: 15 ago. 2025.
MACCARRONE, M. et al. The endocannabinoid system in human keratinocytes. Journal of Biological Chemistry, v. 278, p. 33896–33903, 2003. Disponível em: https://pubmed.ncbi.nlm.nih.gov/12871974/. Acesso em: 15 ago. 2025.
NAKAJIMA, Y. et al. Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-κB pathway inhibition. FEBS Letters, v. 580, p. 613–619, 2006. Disponível em: https://pubmed.ncbi.nlm.nih.gov/16375947/. Acesso em: 15 ago. 2025.
OSSOLA, C.A. et al. Signs of alveolar bone damage in early stages of periodontitis and its prevention by stimulation of cannabinoid receptor 2. Model in rats. Acta Odontológica Latinoamericana, v. 33, p. 143–152, 2020. Disponível em: https://www.actaodontologica.com.ar/. Acesso em: 15 ago. 2025.
PALLADINI, M.C. Indications for the use of cannabinoids. Brazilian Journal of Pain, São Paulo, v. 6, p. S142–S145, 2023. Disponível em: https://doi.org/10.5935/2595-0118.20230054-pt. Acesso em: 15 ago. 2025.
RAPHAEL-MIZRAHI, B.; GABET, Y. The cannabinoids effect on bone formation and bone healing. Current Osteoporosis Reports, v. 18, p. 433–438, 2020. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32783652/. Acesso em: 15 ago. 2025.
STAHL, V.; VASUDEVAN, K. Comparison of efficacy of cannabinoids versus commercial oral care products in reducing bacterial content from dental plaque: a preliminary observation. Cureus, v. 12, p. e6809, 2020. Disponível em: https://www.cureus.com/articles/38062-comparison-of-efficacy-of-cannabinoids-versus-commercial-oral-care-products-in-reducing-bacterial-content-from-dental-plaque-a-preliminary-observation. Acesso em: 15 ago. 2025.
WHYTE, L. et al. Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro. British Journal of Pharmacology, v. 165, p. 2584–2597, 2012. Disponível em: https://pubmed.ncbi.nlm.nih.gov/22329758/. Acesso em: 15 ago. 2025.