EFECTO DE LA SUPLEMENTACIÓN DE PROBIÓTICOS Y PREBIÓTICOS COMO COADYUVANTES EN EL TRATAMIENTO DE LA DEPRESIÓN: UNA REVISIÓN INTEGRATIVA
DOI:
https://doi.org/10.56238/levv16n55-073Palabras clave:
Probióticos, Prebióticos, Síntomas DepresivosResumen
La depresión es un trastorno mental altamente prevalente que afecta significativamente la calidad de vida. Tradicionalmente tratados mediante enfoques farmacológicos y psicoterapéuticos, nuevos estudios han explorado el eje microbiota-intestino-cerebro como una ruta complementaria de tratamiento. En este contexto, el uso de probióticos y prebióticos ha ganado atención debido a sus potenciales efectos beneficiosos sobre la salud mental, influyendo positivamente en los síntomas depresivos. Por esta razón, el presente estudio se propuso, a través de una revisión integradora de la literatura, verificar el uso de estos compuestos en individuos con trastornos depresivos, donde buscamos resaltar vacíos en el conocimiento actual y promover el acercamiento entre nutrición y salud mental. La investigación se realizó mediante la búsqueda de estudios disponibles en las bases de datos PubMed, Cochrane y Science direct, utilizando los descriptores “Probióticos”, “Prebióticos”, “Depresión”, combinados por los operadores booleanos “Y y O”. Se concluye que el uso de probióticos y prebióticos como vía terapéutica complementaria indica resultados satisfactorios en el tratamiento de los síntomas depresivos. Teniendo en cuenta la falta de estandarización y evaluación continua del uso de estos suplementos, es importante resaltar que los resultados deben ser analizados diligentemente, de esta manera los efectos moduladores tendrán mayor respaldo para su uso. Por lo tanto, también es necesario realizar más pruebas con dosis, tiempo y métodos con estándares específicos para un resultado más confiable.
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BARTOS, A.; WEINEROVA, J.; DIONDET, S. Effects of human probiotics on memory and psychological and physical measures in community-dwelling older adults with normal and mildly impaired cognition: results of a bi-center, double-blind, randomized, and placebo-controlled clinical trial (CleverAge biota). Frontiers in Aging Neuroscience, v. 15, 7 jul. 2023.
BINDELS, L. B. et al. Towards a more comprehensive concept for prebiotics. Nature Reviews Gastroenterology & Hepatology, v. 12, n. 5, p. 303–310, 31 mar. 2015.
BOCKTING, C. L. et al. A lifetime approach to major depressive disorder: The contributions of psychological interventions in preventing relapse and recurrence. Clinical Psychology Review, v. 41, p. 16–26, nov. 2015. DOI: 10.1016/j.cpr.2015.02.003.
CHEN, S. et al. Prevalence, progress, and subgroup disparities in pharmacological antidepressant treatment of those who screen positive for depressive symptoms: a repetitive cross-sectional study in 19 European countries. The Lancet Regional Health – Europe, v. 17, p.100368, jun. 2022. DOI: 10.1016/j.lanepe.2022.100368.
CRYAN, J. F. et al. The microbiota-gut-brain axis. Physiological Reviews, v. 99, n. 4, p. 1877-2013, 28 ago. 2019. DOI: 10.1152/physrev.00018.2018.
DEEHAN, E. C. et al. Perspective: Revisiting the concepts of prebiotic and prebiotic effect in light of scientific and regulatory progress – A consensus paper from the Global Prebiotic Association (GPA). Advances in Nutrition, p. 100329, out. 2024. DOI: 10.1016/j.advnut.2024.100329.
FREIJY, T. M. et al. Effects of a high-prebiotic diet versus probiotic supplements versus synbiotics on adult mental health: The “Gut Feelings” randomised controlled trial. Frontiers in Neuroscience, v. 16, 6 fev. 2023.
FULLER, R. Probiotics in human medicine. Gut, v. 32, n. 4, p. 439-442, 1 abr. 1991. DOI: 10.1136/gut.32.4.439.
GIBSON, G. R.; ROBERFROID, M. B. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. The Journal of Nutrition, v. 125, n. 6, p. 1401–1412, 1 jun. 1995. DOI:10.1093/jn/125.6.1401.
HAGHIGHAT, N.; RAJABI, S.; MOHAMMADSHAHI, M. Effect of synbiotic and probiotic supplementation on serum brain-derived neurotrophic factor level, depression and anxiety symptoms in hemodialysis patients: a randomized, double-blinded, clinical trial. Nutritional Neuroscience, p. 1–10, 4 ago. 2019.
HEIDARZADEH-RAD, N. et al. Effects of a Psychobiotic Supplement on Serum Brain-derived Neurotrophic Factor Levels in Depressive Patients: A Post Hoc Analysis of a Randomized Clinical Trial. Journal of Neurogastroenterology and Motility, v. 26, n. 4, p. 486–495, 30 set. 2020.
HILL, C. et al. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nature reviews. Gastroenterology & hepatology, v. 11, n. 8, p. 506–14, 2014.
KENNEDY, P. J. et al. Irritable bowel syndrome: a microbiome-gut-brain axis disorder? World Journal of Gastroenterology, v. 20, n. 39, p. 14105, 2014. DOI: 10.3748/wjg.v20.i39.14105.
KESSLER, R. C. et al. Age differences in the prevalence and co-morbidity of DSM-IV major depressive episodes: results from the WHO World Mental Health Survey Initiative. Depression and Anxiety, v. 27, n. 4, p. 351–364, abr. 2010.
MARX, W. et al. Major depressive disorder. Nature Reviews Disease Primers, v. 9, n. 1, p. 44, 24 ago. 2023. DOI: 10.1038/s41572-023-00454-1
MINISTÉRIO DA SAÚDE. Depressão. Disponível em: https://www.gov.br/saude/pt-br/assuntos/saude-de-a-a-z/d/depressao. Acesso em: 30 maio 2025.
MOINUL, D. et al. Patient Perceptions of Microbiome-Based Therapies as Novel Treatments for Mood Disorders: A Mixed Methods Study. The Canadian journal of psychiatry/Canadian journal of psychiatry, 28 fev. 2024.
NALIBOFF, B. D. et al. Evidence for decreased activation of central fear circuits by expected aversive visceral stimuli in IBS patients. Gastroenterology, v. 118, n. 4, 1 abr. 2000. DOI:10.1016/S0016-5085(00)82626-8
NATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE. Depression in adults: treatment and management. London: NICE, 2022.
NIKOLOVA, V. L. et al. Perturbations in gut microbiota composition in psychiatric disorders: a review and meta-analysis. JAMA Psychiatry, v. 78, n. 12, p. 1343–1354, 2021. DOI: 10.1001/jamapsychiatry.2021.2573.
O’MAHONY, S. M. et al. Maternal separation as a model of brain–gut axis dysfunction. Psychopharmacology, v. 214, n.1, p. 71–88, 2011. DOI: 10.1007/s00213-010-2010-9.
PETER P.J. JACKSON et al. Inulin-type fructans and 2’fucosyllactose alter both microbial composition and appear to alleviate stress-induced mood state in a working population compared to placebo (maltodextrin): the EFFICAD Trial, a randomized, controlled trial. The American Journal of Clinical Nutrition, v. 118, n. 5, p. 938–955, 1 nov. 2023.
QASEEM, A. et al. Nonpharmacologic and pharmacologic treatments of adults in the acute phase of major depressive disorder: a living clinical guideline from the American College of Physicians. Annals of Internal Medicine, v. 176, n. 2, p. 239–252, 2023. DOI: 10.7326/M22-2056.
RADFORD-SMITH, D. E.; ANTHONY, D. C. Prebiotic and probiotic modulation of the microbiota–gut–brain axis in depression. Nutrients, v. 15, n. 8, p. 1880, 2023. DOI: 10.3390/nu15081880.
ROSSOM, R. C. et al. Antidepressant adherence across diverse populations and healthcare settings. Depression and Anxiety, v. 33, n. 8, p. 765–774, 2016. DOI: 10.1002/da.22532.
SANTOMAURO, D. F. et al. Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic. The Lancet, v. 398, n. 10312, p. 1700–1712, 6 nov. 2021. DOI: 10.1016/S0140-6736(21)02143-7.
SARKAR, A. et al. Psychobiotics and the manipulation of bacteria–gut–brain signals. Trends in Neurosciences, v. 39, n. 11, p. 763–781, 2016. DOI: 10.1016/j.tins.2016.09.002
STECHER, C.; CLOONAN, S.; DOMINO, M. E. The economics of treatment for depression. Annual Review of Public Health, v. 45, n. 1, p. 527-551, 2023. DOI: 10.1146/annurev-publhealth-061022-040533.
TARUTANI, S. et al. Effects of 4G-beta-D-Galactosylsucrose in patients with depression: A randomized, double-blinded, placebo-controlled, parallel-group comparative study. Journal of Psychiatric Research, v. 148, p. 110–120, abr. 2022.
TENEA, G. N.; YÉPEZ, L. Probiotics and prebiotics in human nutrition and health. In: RAO, V. (Ed.). Probiotics and prebiotics in human nutrition and health. Rijeka: InTech, 2016. DOI: 10.5772/61495.