NEUROPSYCHIATRIC DISORDERS ASSOCIATED WITH CHILDHOOD EPILEPSY: COGNITIVE, BEHAVIORAL, AND THERAPEUTIC IMPACTS: A SYSTEMATIC REVIEW

Authors

  • Ana Luisa Tomborelli Saia Author
  • Kharime Charara Author
  • Beatriz Camargo de Moraes Barreira Author
  • Ana Beatriz de Araújo Andrade Author
  • Letícia Pastana De Mello Author
  • Rafael Eduardo de Souza Santos Author
  • Lívia Rojas Brandemarte Author
  • Isabela de Angelles Floro Alonso Author
  • Leonardo Max Batista Araújo Author
  • Maria Eduarda Taglietti Espíndola Author
  • Victoria Falcão Battistella Author

DOI:

https://doi.org/10.56238/levv17n57-058

Keywords:

Epilepsy, Child, Neurodevelopmental Disorders, Mental Health

Abstract

Introduction: Childhood epilepsy is a chronic neurological condition frequently accompanied by a broad spectrum of neuropsychiatric comorbidities that significantly affect development and quality of life.

Objective: The main objective of this systematic review was to evaluate the prevalence, clinical patterns, and therapeutic implications of neuropsychiatric disorders associated with childhood epilepsy, with secondary objectives addressing cognitive outcomes, behavioral profiles, pharmacological interactions, psychosocial impact, and long-term prognosis.

Results and Discussion: Twenty studies were included, demonstrating high rates of cognitive impairment, attention-deficit/hyperactivity disorder, autism spectrum disorder, anxiety, depression, and behavioral dysregulation, with complex bidirectional interactions between seizures, antiepileptic drugs, and neurodevelopment.

Methods: A systematic search was conducted across PubMed, Scopus, Web of Science, Cochrane Library, LILACS, ClinicalTrials.gov, and ICTRP, applying predefined inclusion and exclusion criteria and synthesizing evidence using standardized risk-of-bias tools.Results and Discussion: Twenty studies were included, demonstrating high rates of cognitive impairment, attention-deficit/hyperactivity disorder, autism spectrum disorder, anxiety, depression, and behavioral dysregulation, with complex bidirectional interactions between seizures, antiepileptic drugs, and neurodevelopment.

Conclusion: Early identification and integrated management of neuropsychiatric comorbidities are essential to optimize clinical outcomes and promote individualized, multidisciplinary care in children with epilepsy.

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Published

2026-02-19

Issue

Vol. 17 No. 57 (2026): Vol. XVII Núm. LVII - 2026

Section

Articles

How to Cite

SAIA, Ana Luisa Tomborelli et al. NEUROPSYCHIATRIC DISORDERS ASSOCIATED WITH CHILDHOOD EPILEPSY: COGNITIVE, BEHAVIORAL, AND THERAPEUTIC IMPACTS: A SYSTEMATIC REVIEW. LUMEN ET VIRTUS, [S. l.], v. 17, n. 57, p. e12241, 2026. DOI: 10.56238/levv17n57-058. Disponível em: https://periodicos.newsciencepubl.com/LEV/article/view/12241. Acesso em: 24 feb. 2026.