MANAGEMENT OF ANTISOCIAL PERSONALITY DISORDER: CHALLENGES AND THERAPEUTIC POSSIBILITIES

Authors

  • Michelle Tatiane de Souza França Author
  • Ryan Rafael Barros de Macedo Author
  • Nailon de Morais Kois Author
  • Rafaella Marcelino Ribeiro Author
  • Alex Canarin Omari Author
  • Manuela Simões Pires Martins Author
  • Júlia Dal Bó Cassettari Author
  • Vitória Carolina Reis Batista Author
  • Lethicia Hammerschmidt Goulart Author
  • Gabriela Decker Author
  • Luana Felicia Maia Author
  • Shely Pinto Frazão Rodrigues Author
  • Julia Ribeiro Teixeira Author

DOI:

https://doi.org/10.56238/levv17n57-010

Keywords:

Antisocial Personality Disorder, Violence, Clinical Management, Diagnosis, Treatment

Abstract

Antisocial Personality Disorder (ASPD) is defined by a persistent disregard for the rights of others, manifesting itself through exploitative and delinquent behaviors, often devoid of remorse, as well as difficulty in following social norms and maintaining relationships. It is a condition associated with violence and recidivism, increasing the risk of interpersonal violence. ASPD goes beyond the idea of ​​a simple behavioral deviation or a character flaw, and should be understood as a complex clinical condition, underpinned by profound alterations in neuropsychological functioning. This literature review aims to analyze the main challenges and strategies in the management of ASPD, based on data collected from the PubMed database using the MeSH descriptors "Antisocial Personality Disorder," "Treatment," and "Diagnosis." The findings indicate that the prognosis of ASPD is influenced by unfavorable early experiences, leading to "emotional shielding" in the face of authority figures. Thus, Antisocial Personality Disorder (ASPD) is configured as an intricate psychiatric condition, presenting social repercussions, challenging therapeutic interventions, causing significant functional impairments, and a strong association with violent behaviors. It is concluded that the prognosis tends to be unfavorable, especially due to demotivation and abandonment of treatment, reinforcing the need for continuous and multidimensional clinical strategies.

Downloads

Download data is not yet available.

References

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Disponível em: https://doi.org/10.1176/appi.books.9780890425596 Acesso em 19 jan. 2026.

CHOW, R. T. S. et al. Personality disorders, violence and antisocial behaviour: updated systematic review and meta-regression analysis. The British Journal of Psychiatry, v. 227, n. 1, p. 481-491, 2025.

DE VRIES, N. et al. Childhood adversity and treatment outcome in forensic patients with antisocial personality disorder. The Journal of Forensic Psychiatry & Psychology, v. 35, n. 2, p. 210-228, 2024.

FISHER, K. A. et al. Antisocial Personality Disorder (Nursing). StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2024.

HICKS, M. R. et al. Ketamine-Assisted Psychotherapy for Antisocial Personality Disorder: A Case Report. Journal of Psychoactive Drugs, p. 1-7, 2025.

JEUNG-MAARSE, H., Schmitgen, M.M., Schmitt, R. et al. Oxytocin effects on amygdala reactivity to angry faces in males and females with antisocial personality disorder. Neuropsychopharmacol. 48, 946–953 (2023).

LESCH, K. P.; GORBUNOV, N. Antisocial personality disorder: Failure to balance excitation/inhibition? Neuropharmacology, v. 268, p. 110321, 2025.

LOW, A. et al. Association patterns of antisocial personality disorder across substance use disorders. Translational Psychiatry, v. 14, p. 346, 2024.

SANCHEZ GODDARD, G. P. et al. Antisocial Personality Disorder in Mexican Women: A Study of Sociodemographic Variables and Comorbid Mental Disorders. Cureus, v. 17, n. 3, p. e80035, 2025.

TICK, B. et al. The genetic architecture of antisocial behavior: a meta-analysis of genome-wide association studies. Molecular Psychiatry, v. 29, n. 4, p. 1120-1135, 2024.

ZEIGLER, K. et al. Neuromodulation in Personality Disorders: A systematic review of non-invasive brain stimulation for Antisocial and Borderline clusters. Journal of Psychiatric Research, v. 181, p. 42-55, 2025.

GIBBON, S. et al. Psychological interventions for antisocial personality disorder. Cochrane Database of Systematic Reviews, v. 9, 2020. DOI: 10.1002/14651858.CD007668.pub2. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32880104/. Acesso em: 16 jan. 2026.

Fisher KA, Torrico TJ, Hany M. Antisocial Personality Disorder. [Updated 2024 Feb 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan

Published

2026-02-05

How to Cite

FRANÇA, Michelle Tatiane de Souza et al. MANAGEMENT OF ANTISOCIAL PERSONALITY DISORDER: CHALLENGES AND THERAPEUTIC POSSIBILITIES. LUMEN ET VIRTUS, [S. l.], v. 17, n. 57, p. e12062, 2026. DOI: 10.56238/levv17n57-010. Disponível em: https://periodicos.newsciencepubl.com/LEV/article/view/12062. Acesso em: 8 feb. 2026.