EFFECTS OF VITAMIN D SUPPLEMENTATION ON IRRITABLE BOWEL SYNDROME SYMPTOMS: AN INTEGRATIVE REVIEW
DOI:
https://doi.org/10.56238/levv16n55-033Keywords:
Irritable Bowel Syndrome, Vitamin D, Inflammatory Bowel Disease, Nutritional, SupplementationAbstract
Irritable Bowel Syndrome (IBS) is considered a functional disorder of the gastrointestinal tract that involves alterations in the intestinal microbiota, with a low-grade inflammatory state and dysregulation of intestinal immunity. This disorder is characterized by frequent abdominal pain accompanied by bloating, unstable bowel habits, with variations or predominance of constipation and/or diarrhea, as well as gas and flatulence. Individuals affected by this disorder experience impairments in several aspects of quality of life, particularly in relation to diet, due to the need for nutritional therapy, as well as the financial burden of medical consultations, examinations, and medications, in addition to social impairment and consequent psychological impacts, such as anxiety and depression. Supplementation with vitamin D3 (cholecalciferol) in IBS has been widely studied, and evidence has demonstrated improvements in quality of life and reductions in symptoms. Increased serum levels of cholecalciferol have been associated with anti-inflammatory, antimicrobial, and immunomodulatory mechanisms acting on the intestinal barrier, promoting a reduction in intestinal microbiota inflammation and improvement of its function. This study aimed to evaluate the effects of vitamin D supplementation on symptoms of irritable bowel syndrome. A literature search was conducted to investigate the effects of vitamin D supplementation in individuals with IBS and the potential for symptom improvement. Improvements in symptom intensity and frequency were observed with weekly cholecalciferol supplementation. Evidence suggests a positive effect of vitamin D supplementation in individuals with IBS; however, further studies are needed to support and confirm this therapeutic strategy.
Downloads
References
AGGELETOPOULOU, Ioanna; GERAMOUTSOS, Georgios; PASTRAS, Ploutarchos; TRIANTOS, Christos.Vitamina D na Síndrome do Intestino Irritável: Explorando seu Papel no Alívio dos Sintomas e na Fisiopatologia. Nutrients, v. 17, n. 6, p. 1028, 14 mar. 2025. DOI: https://doi.org/10.3390/nu17061028
ALEMAN, R. S.; MONCADA, M.; ARYANA, K. J. Intestino permeável e os ingredientes que ajudam a tratá-lo: uma revisão. Molecules, v. 28, n. 2, p. 619, 2023. DOI: https://doi.org/10.3390/molecules28020619.
AKIHO, H.; IHARA, E.; NAKAMURA, K. Low-grade inflammation plays a pivotal role in gastrointestinal dysfunction in irritable bowel syndrome. World Journal of Gastrointestinal Pathophysiology, v. 1, n. 3, p. 97–105, 15 ago. 2010. DOI: 10.4291/wjgp.v1.i3.97. Disponível em: https://www.wjgnet.com/2150-5330/full/v1/i3/97.htm
ANDRADE, V. L. A. et al. FODMAPs restricted diet as a treatment option in irritable bowel syndrome: systematic review. Gastroenterologia, Endoscopia e Digestão, v. 34, n. 1, p. 34-41, jan./mar. 2015
ALVES, F. A. da S. et al. Relação entre vitamina D e doenças inflamatórias intestinais. Brazilian Journal of Development, Curitiba, v. 9, n. 6, p. 19721–19735, jun. 2023. DOI: 10.34117/bjdv9n6-067. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/60634. Acesso em: 28 maio 2025
ANDRAE, D. A.; PATRICK, D. L.; DROSSMAN, D. A.; COVINGTON, Paul S. Evaluation of the Irritable Bowel Syndrome Quality of Life (IBS-QOL) questionnaire in diarrheal-predominant irritable bowel syndrome patients. Health and Quality of Life Outcomes, v. 11, art. 208, 13 dez. 2013. DOI: 10.1186/1477-7525-11-208. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895767/
BATTISTINI, C. et al. Vitamin D modulates intestinal microbiota in inflammatory bowel diseases. International Journal of Molecular Sciences, v. 22, n. 1, p. 362, 2020. Disponível em: https://doi.org/10.3390/ijms22010362.
BENNET, S. M. P.; OHMAN, L.; SIMRÉN, M. Gut microbiota as potential orchestrators of irritable bowel syndrome. Gut and Liver, v. 9, n. 3, p. 318–331, 2015. DOI: 10.5009/gnl14265.
BIZZARO, G.; ANTICO, A.; FORTUNATO, A.; BIZZARO, N. Vitamin D and autoimmune diseases: is vitamin D receptor (VDR) polymorphism the culprit? Israel Medical Association Journal, v. 19, n. 7, p. 438-443, jul. 2017. Disponível em: https://pubmed.ncbi.nlm.nih.gov/28786260/. Acesso em: 12 nov. 2025.
BURNS, G. L.; TALLEY, N. J.; KEELY, S. Immune responses in the irritable bowel syndromes: time to consider the small intestine. BMC Medicine, v. 20, art. 115, 2022. DOI: 10.1186/s12916-022-02301-8.
CAIXETA, M. A. et al. Síndrome do intestino irritável: aspectos patogênicos e terapêuticos. Brazilian Journal of Implantology and Health Sciences, v. 6, n. 5, p. 440–447, 7 maio 2024.
CARVALHO L. do C. et al. Doenças inflamatórias intestinais: uma abordagem geral. Revista Eletrônica Acervo Médico, v. 2, p. e9650, 2 fev. 2022. DOI: https://doi.org/10.25248/REAMed.e9650.2022.
CAVALCANTE, R. M. S. et al. O papel da microbiota na etiologia das doenças inflamatórias intestinais. RBONE - Revista Brasileira de Obesidade, Nutrição e Emagrecimento, v. 14, n. 86, p. 498-510, 18 out. 2020.
COTRIM, M. A. et al. O papel da microbiota intestinal na patogênese das doenças inflamatórias intestinais. The role of the intestinal microbiota in the pathogenesis of inflammatory intestinal disease. Revista Brasileira de Saúde. Curitiba, v. 3, n. 3, p. 052, 2020. DOI: 10.34119/bjhrv3n3-052.
COZZOLINO, S.M.F. Biodisponibilidade de nutrientes. 5. ed. Barueri: Editora Manole, 2016.
DINAN, T. G. Hypothalamic-Pituitary-Gut Axis Dysregulation in Irritable Bowel Syndrome. Gastroenterology, v. 130, n. 5, p. 1458-1466, 2006. DOI: 10.1053/j.gastro.2005.10.039.
EL AMROUSY, D.; HASSAN, S.; EL ASHRY, H.; YOUSEF, M.; HODEIB, H. Vitamin D supplementation in adolescents with irritable bowel syndrome: Is it useful? A randomized controlled trial. Saudi Journal of Gastroenterology, v. 24, n. 2, p. 109–114, Mar.–Apr. 2018. DOI: 10.4103/sjg.SJG_438_17.
FERREIRA, A. I; GARRIDO, M; CASTRO-POCAS, F. Irritable Bowel Syndrome: News from na Old Disorder. GE Port J Gastroenterol, Lisboa, v. 27, n. 4, p. 255-268, ago. 2020.Disponível em <http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452020000400007&lng=pt&nrm=iso>.
FERREIRA, G. S.; DEUS, M. H. A.; JUNIOR, E. A.. Fisiopatologia e etiologias das doenças inflamatórias intestinais: uma revisão sistemática de literatura. Pathophysiology and etiologies of the inflammatory bowel diseases: a systematic review. Revista Brasileira de Saúde. Brazilian Journal of Health Review, Curitiba, v. 4, n. 4, p. 17061-17076, jul./aug. 2021. DOI: 10.34119/bjhrv4n4-210
FORD, A. C.; TALLEY, N. J. Mucosal inflammation as a potential etiological factor in irritable bowel syndrome: a systematic review. Journal of Gastroenterology, v. 46, n. 4, p. 421–431, 2011. DOI: 10.1007/s00535-011-0379-9.
JALILI, M.; VAHEDI, H.; POUSTCHI, H.; HEKMATDOOST, A. Effects of Vitamin D Supplementation in Patients with Irritable Bowel Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. International Journal of Preventive Medicine, v. 10, p. 16, 2019. DOI: 10.4103/ijpvm.IJPVM_512_17.
LACY, B. E.; PATEL, N. K. Critérios de Roma e uma abordagem diagnóstica para a síndrome do intestino irritável. Journal of Clinical Medicine, v. 6, n. 11, p. 99, 2017. Disponível em: https://doi.org/10.3390/jcm6110099
MALAGUARNERA, L. Vitamin D and microbiota: Two sides of the same coin in the immunomodulatory aspects. International Immunopharmacology, v. 79, p. 106112, fev. 2020.
MOHAMMED, H. A.; MIRSHAFIEY, A.; VAHEDI, H.; HEMMASI, G.; MOUSSAVI NASL KHAMENEH, A.; PARASTOUEI, K.; SABOOR-YARAGHI, A. A. Immunoregulation of inflammatory and inhibitory cytokines by vitamin D3 in patients with inflammatory bowel diseases. Scandinavian Journal of Immunology, v. 85, n. 3, p. 155–163, 2017. DOI: 10.1111/sji.12547.
NIELSEN, O. H. et al. Gerenciando a deficiência de vitamina D na doença inflamatória intestinal. Revista BMJ, v. 10, n. 4, 2019. Disponível em: http://orcid.org/0000-0003-4612-8635.
O’MALLEY, D.; QUIGLEY, E. M.; DINAN, T. G.; CRYAN, J. F. Do interactions between stress and immune responses lead to symptom exacerbations in irritable bowel syndrome? Brain, Behavior, and Immunity, v. 25, n. 7, p. 1333-1341, out. 2011. DOI: https://doi.org/10.1016/j.bbi.2011.04.009. Disponível em: https://pubmed.ncbi.nlm.nih.gov/21536124/. Acesso em: 12 nov. 2025.
ORTEGA, M. A. et al. Immune-Mediated Diseases from the Point of View of Psychoneuroimmunoendocrinology. Biology, v. 11, n. 7, p. 973, 28 jun. 2022.
OZER, M. et al. Prevalence of irritable bowel syndrome-like symptoms using Rome IV criteria in patients with inactive inflammatory bowel disease and relation with quality of life. Medicine, v. 99, n. 19, p. e20067, maio 2020.
PONTET, Y.; OLANO, C. Prevalencia de síndrome de intestino irritable en América Latina [Irritable bowel syndrome prevalence in Latin America]. Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru, 41(3), 144–149. 2021.
POP, T. L. et al. The Role of Vitamin D and Vitamin D Binding Protein in Chronic Liver Diseases. International Journal of Molecular Sciences, v. 23, n. 18, p. 10705, 14 set. 2022.
SATIA, M.C.; MUKIM, A.G.; TIBREWALA, K.D.; BHAVSAR, M.S. A randomized two-way cross over study for comparison of absorption of vitamin D3 buccal spray and soft gelatin capsule formulation in healthy subjects and in patients with intestinal malabsorption. Nutrition Journal, v. 14, n. 1, art. 114, 2015. DOI: 10.1186/s12937-015-0105-1.
SANTOS, R. M. et al. Doença inflamatória intestinal: perfil do tratamento ambulatorial. Arquivos de Gastroenterologia, v. 54, n. 2, p. 96–100, 2017. DOI: 10.1590/S0004-2803.201700000-01.
SIKAROUDI, M. K.; MOKHTARE, M.; JANANI, L.; FAGHIHI KASHANI, A. H.; MASOODI, M.; AGAH, S.; ABBASPOUR, N.; DEHNAD, A.; SHIDFAR, F. Vitamin D3 supplementation in diarrhea-predominant irritable bowel syndrome patients: the effects on symptoms improvement, serum corticotropin-releasing hormone, and interleukin-6 – a randomized clinical trial. Digestive Diseases, published online on Mar. 23, 2020. DOI: 10.1159/000506149.
SIKAROUDI, M. K.; MOKHTARE, M.; SHIDFAR, F.; JANANI, L.; FAGHIHI KASHANI, A. H.; MASOODI, M.; AGAH, S.; DEHNAD, A.; SHIDFAR, S. Effects of vitamin D3 supplementation on clinical symptoms, quality of life, serum serotonin (5-hydroxytryptamine), 5-hydroxy-indole acetic acid, and ratio of 5-HIAA/5-HT in patients with diarrhea-predominant irritable bowel syndrome: a randomized clinical trial. EXCLI Journal, v. 19, p. 652–667, 2020. DOI: 10.17179/excli2020-2247.
RAYMOND, Janice L.; MORROW, Kelly. Krause & Mahan: Alimentos, nutrição e dietoterapia. 15. ed. Rio de Janeiro: Grupo GEN, 2022. Disponível em: Minha Biblioteca
SILVA, M. T. et al. Diagnóstico e tratamento da síndrome do intestino irritável: revisão sistemática. Pará Research Medical Journal, Belém, Brasil, v. 4, p. 1–8, 2020. DOI: 10.4322/prmj.2019.041. Disponível em: https://prmjournal.emnuvens.com.br/revista/article/view/59
SPEAR, E. T.; MAWE, G. M. Enteric neuroplasticity and dysmotility in inflammatory disease: key players and possible therapeutic targets. American Journal of Physiology – Gastrointestinal and Liver Physiology, Bethesda, v. 317, n. 6, p. G853–G861, 2019. DOI: 10.1152/ajpgi.00206.2019.
Weber J. B.; Weber C. de S. B.; Ferraz A. R. Síndrome do Intestino Irritável: uma revisão de literatura. Revista Eletrônica Acervo Médico, v. 18, p. e11009, 3 out. 2022. DOI: https://doi.org/10.25248/reamed.e11009.2022
WILLIAMS, C. E.; WILLIAMS, E. A.; CORFE, B. M. Vitamin D supplementation in people with IBS has no effect on symptom severity and quality of life: results of a randomised controlled trial. European Journal of Nutrition, v. 61, p. 299–308, 2022. DOI: 10.1007/s00394-021-02633-w.
ZAREI, D.; SAGHAZADEH, A.; REZAEI, N. Subtyping irritable bowel syndrome using cluster analysis: a systematic review. BMC Bioinformatics, v. 24, n. 1, p. 478, 15 dez. 2023. DOI: 10.1186/s12859-023-05567-8.
