EARLY INTERVENTIONS IN PATIENTS WITH SEPSIS: IMPACT ON MORTALITY AND EVIDENCE-BASED PROTOCOLS

Abstract

Sepsis is one of the main causes of morbidity and mortality in hospitals, characterized by a dysregulated inflammatory response to infections that can rapidly progress to organ dysfunction and death. Given its high lethality and pathophysiological complexity, early interventions emerge as essential strategies to improve clinical outcomes. This study aimed to conduct a literature review on the main therapeutic measures implemented in the early stages of sepsis and their impact on reducing mortality. Publications indexed in databases such as PubMed, Scopus, Web of Science, Embase, Lilacs and Cochrane Library were analyzed, considering articles published between 2010 and 2025. Critical analysis of the data showed that early identification of sepsis, combined with immediate administration of antimicrobials, adequate volume replacement and continuous monitoring, constitute a set of actions that significantly reduce mortality rates. The importance of training health teams and implementing evidence-based clinical protocols as pillars for effectively dealing with sepsis in health services is also highlighted.