Contribution to the chemical study of Chrysobalanus icaco leaves

Abstract

Chrysobalanus icaco (Chrysobalanaceae), is a shrub in Brazil, occurs throughout the coast and in the Amazon biome, known as abajurú, abajerú, bajerú, guajurú, among other popular names. In folk medicine, it is mainly used to control blood glucose in diabetics, dysentery and leukorrhea. There are studies in the scientific literature that confirm its antidiabetic effects. From a chemical point of view, the species is characterized as a bioproducer of terpene and phenolic compounds.  The objective of this work is to contribute to the chemical studies of the species C. icaco, considering its relevant pharmacological activities. In this work we present the isolation and characterization of two triterpenes and three flavonoids, in addition to the product obtained by acetylation reaction of an ethyl acetate fraction identified as 2α, 3β-diacetoxy-6β-hydroxy-olean-12-en-28-oate of [β-D-triacetoxy-glycopyranosyl (2→1) – β - triacetoxy-xylopyranosyl]. The structural determination of the substances was made through the analysis of 1D and 2D nuclear magnetic resonance spectra and HR-ESI-MS mass spectrometry and comparison with values recorded in the literature.