INCIDENTAL FINDING OF HEPATOCYTIC PROLIFERATION OF UNCERTAIN BIOLOGICAL BEHAVIOR

Abstract

Since 1995, research on liver tumors has been driven by groups such as the International Working Party (IWP) and the International Consensus Group for Hepatocellular Neoplasia (ICHN). These groups classified liver nodules into regenerative lesions, such as focal nodular hyperplasia, and dysplastic or neoplastic lesions, such as adenomas and hepatocellular carcinomas. Hepatocellular adenomas occur more in young women, often linked to the use of combined oral contraceptives, whereas hepatic hemangiomas and focal nodular hyperplasia usually remain benign but may require follow-up if they increase in size. The diagnosis of liver tumors is made mainly by imaging tests, and biopsy is used to evaluate the histological type. Treatment ranges from conservative to surgical, depending on size, symptoms, and malignant potential. In asymptomatic incidental findings, management is usually conservative. However, large, symptomatic, or malignant tumors require surgical intervention, and may include resection or chemotherapy in advanced cases. Little is said in the literature about uncertain histopathological behaviors, a fact that this research seeks to elucidate and help the scientific community.