SERUM LEPTIN LEVELS AND THEIR ASSOCIATION WITH OVULATORY FAILURE IN OBESE BITCHES
DOI:
https://doi.org/10.56238/ERR01v11n1-016Keywords:
Adipokines, Veterinary Endocrinology, Female Fertility, Energy Metabolism, Animal ReproductionAbstract
Obesity in dogs has become an increasingly frequent health problem, being associated with metabolic and endocrine changes that can interfere with female reproductive function. Considering the scarcity of specific studies that relate hormonal changes resulting from excess adipose tissue to ovulatory dysfunction in female dogs, the objective of this study was to analyze the association between hormonal changes related to energy metabolism and the occurrence of ovulatory dysfunction in overweight female dogs. To this end, a narrative literature review was conducted using a qualitative approach based on the critical analysis of scientific articles, reviews, dissertations, and theses obtained from national and international databases. Thus, it was observed that increased adipose mass is consistently associated with elevated circulating adipokines and the development of hormonal resistance, factors that can compromise ovulation and fertility. It was therefore concluded that hormonal changes associated with excess weight represent a potential risk factor for ovulatory dysfunction in female dogs.
Downloads
References
AHIMA, R. S. et al. Role of leptin in the neuroendocrine response to fasting. Nature, Londres, v. 382, n. 6588, p. 250–252, 1996.
BARCELLAR, R. F.; VALADARES, T. C.; CIARLINI, P. C. Alterações do metabolismo energético de cães obesos: revisão sistemática e metanálise. Revista Foco, Curitiba, v. 17, n. 3, e4724, 2024.
BRANNIAN, J. D.; HANSEN, K. A. Leptin and ovarian folliculogenesis: implications for ovulation induction and fertility. Reproductive Biology and Endocrinology, Londres, v. 24, n. 1, p. 1–7, 2002.
CARZOLI, A.; MEIKLE, A.; PESSINA, P. Canine obesity, overweight, and adipokine serum concentration are associated with hematological, biochemical, hormonal, and cardiovascular markers. Open Veterinary Journal, Tripoli, v. 15, n. 2, p. 619–629, 2025.
CASTRACANE, V. D.; HENSON, M. C. Leptin’s role in reproduction: review of evidence. Journal of Endocrinology, Bristol, v. 179, n. 3, p. 291–301, 2003.
CHILDS, G. V. et al. Importance of leptin to reproduction. Endocrinology, Oxford, v. 162, n. 2, bqaa204, 2021.
CONSIDINE, R. V. et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New England Journal of Medicine, Boston, v. 334, n. 5, p. 292–295, 1996.
COURCIER, E. A. et al. Risk factors for canine obesity in veterinary practices in the United Kingdom. Veterinary Journal, Londres, v. 184, n. 2, p. 214–220, 2010.
EVANS, M. C. et al. Multiple leptin signalling pathways in the control of metabolism and reproductive function. International Journal of Molecular Sciences, Basel, v. 22, n. 17, p. 9210, 2021.
FRIEDMAN, J. M.; HALAAS, J. L. Leptin and the regulation of body weight in mammals. Nature, Londres, v. 395, n. 6704, p. 763–770, 1998.
GERMAN, A. J. The growing problem of obesity in dogs and cats. Journal of Nutrition, Oxford, v. 136, n. 7, p. 1940S–1946S, 2006.
HAUSMAN, G. J. et al. The biology of leptin in the pig. Domestic Animal Endocrinology, Amsterdã, v. 43, n. 1, p. 1–11, 2012.
LAFLAMME, D. P. Understanding and managing obesity in dogs and cats. Veterinary Clinics of North America: Small Animal Practice, Filadélfia, v. 36, n. 6, p. 1283–1295, 2006.
MAFFE I, M. et al. Leptin levels in human and rodent: measurement and physiological relevance. Journal of Clinical Investigation, Nova Iorque, v. 95, n. 6, p. 2518–2524, 1995.
MARQUES, C. et al. Obesity-induced inflammation and metabolic dysfunction in dogs. Animals, Basel, v. 10, n. 8, p. 1391, 2020.
MAURY, E.; BRICHARD, S. M. Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Molecular and Cellular Endocrinology, Amsterdã, v. 314, n. 1, p. 1–16, 2010.
MCGREEVY, P. D. et al. Prevalence of obesity in dogs examined by Australian veterinary practices. Australian Veterinary Journal, Canberra, v. 83, n. 6, p. 315–321, 2005.
MIYAI, R. et al. Obesity and reproductive disorders in female dogs. Theriogenology, Nova Iorque, v. 165, p. 1–7, 2021.
MOSLEHI, N. et al. Ovarian leptin resistance in obesity-related infertility. Journal of Endocrinological Investigation, Roma, v. 41, n. 7, p. 839–848, 2018.
MYERS, M. G. et al. Mechanisms of leptin action and leptin resistance. Annual Review of Physiology, Palo Alto, v. 72, p. 537–556, 2010.
PÉREZ-PÉREZ, A. et al. Role of leptin in female reproduction. Clinical Chemistry and Laboratory Medicine, Berlim, v. 53, n. 1, p. 15–28, 2015.
PIANTEDOSI, D. et al. Effect of a weight loss program on biochemical and immunological profile, serum leptin levels, and cardiovascular parameters in obese dogs. Frontiers in Veterinary Science, Lausanne, v. 7, p. 398, 2020.
RADIN, M. J. et al. Serum leptin concentrations in lean and obese dogs. Journal of Veterinary Internal Medicine, Hoboken, v. 23, n. 2, p. 372–378, 2009.
RAMOS, A. G. C. et al. Canine obesity: contributing factors and body condition evaluation. Pets, Basel, v. 2, n. 2, p. 22, 2025.
ROBKER, R. L. et al. Mechanisms of obesity-induced ovarian dysfunction. Reproduction, Cambridge, v. 137, n. 4, p. 613–626, 2009.
SHARMA, Y.; GALVÃO, A. M. Maternal obesity and ovarian failure: is leptin the culprit? Animal Reproduction, Belo Horizonte, v. 19, n. 4, e20230007, 2022.
TEIXEIRA, S. V. Análise sérica de leptina, IL-6, IGF-1 e estrógeno em cadelas com excesso de peso e carcinomas mamários em estágio inicial. 2017. Dissertação (Mestrado em Patologia) – Universidade Federal de Minas Gerais, Belo Horizonte, 2017.
VELAZQUEZ, M. A. The role of leptin in mammalian oocyte developmental competence. Theriogenology, Nova Iorque, v. 220, p. 12–20, 2025.
ZORAN, D. L. Obesity in dogs and cats: a metabolic and endocrine disorder. Veterinary Clinics of North America: Small Animal Practice, Filadélfia, v. 40, n. 2, p. 221–239, 2010.