SYSTEMATIC REVIEW: INTERMITTENT FASTING AS AN ADJUVANT STRATEGY IN METASTATIC TRIPLE NEGATIVE BREAST CANCER
Keywords:
Advanced Breast Neoplasms, Fasting-Mimicking Diet, Adjunctive Therapies, Tumor ResistanceAbstract
Triple-negative breast cancer (TNBC) is the most aggressive subtype of the disease, marked by high recurrence rates and limited therapeutic response, especially in metastatic stages. In this context, adjunctive strategies such as intermittent fasting and the fasting-mimicking diet (FMD) have gained attention due to their potential effects on tumor progression, metabolic modulation, and reduction of treatment-related toxicity. This systematic review analyzed seven relevant studies, including experimental, clinical, and review articles, assessing the impact of fasting on TNBC management. Findings indicate potential benefits, such as decreased inflammation, increased tumor sensitivity to conventional therapies, and reduced damage to normal cells, although human data remain limited. In conclusion, intermittent fasting and FMD emerge as promising yet experimental strategies, and further well-designed clinical trials are required to establish their efficacy and safety in patients with metastatic TNBC.
