SÍNDROME CORONARIO AGUDO: DIAGNÓSTICO PRECOZ Y MANEJO TERAPÉUTICO EN URGENCIAS
DOI:
https://doi.org/10.56238/levv17n57-046Palabras clave:
Síndrome Coronario Agudo, Diagnóstico Precoz, Medicina de Urgencias, Infarto de Miocardio, TratamientoResumen
Las enfermedades cardiovasculares continúan siendo la principal causa de morbimortalidad a nivel mundial, y el síndrome coronario agudo (SCA) constituye un desafío central en los servicios de urgencias y emergencias. Esta revisión narrativa sintetiza evidencias publicadas entre 2021 y 2025 sobre el diagnóstico precoz y el manejo del SCA en el contexto asistencial de emergencia. El diagnóstico contemporáneo se basa en la integración de la evaluación clínica, el electrocardiograma de 12 derivaciones y biomarcadores cardíacos de alta sensibilidad, especialmente la troponina. La adopción de algoritmos diagnósticos acelerados (0/1 h y 0/2 h) ha incrementado la eficiencia y la seguridad del flujo asistencial, permitiendo la exclusión fiable del infarto agudo de miocardio en pacientes de bajo riesgo cuando se aplica en concordancia con el juicio clínico. La estratificación del riesgo se optimiza mediante el uso de escalas validadas, destacándose el puntaje HEART en la predicción de mortalidad a corto plazo y el T-MACS en la identificación de pacientes con mayor riesgo de eventos cardiovasculares adversos mayores. En el SCA sin elevación persistente del segmento ST, el momento de la coronariografía se determina según el perfil de riesgo isquémico, recomendándose una estrategia invasiva inmediata en pacientes de muy alto riesgo y una estrategia precoz en aquellos de alto riesgo. El manejo terapéutico inicial incluye antiagregación plaquetaria y anticoagulación, equilibrando el beneficio isquémico y el riesgo hemorrágico. Persisten desafíos relacionados con la heterogeneidad de las presentaciones clínicas y las desigualdades asistenciales, especialmente en mujeres y adultos mayores. En conjunto, los avances recientes apuntan hacia un modelo de atención progresivamente orientado por la estratificación del riesgo, protocolos estandarizados e integración tecnológica.
Descargas
Referencias
Akman, G., et al. (2023). T-MACS score vs HEART score identification of major adverse cardiac events in the emergency department. American Journal of Emergency Medicine, 64, 21–25. https://doi.org/10.1016/j.ajem.2022.11.015 DOI: https://doi.org/10.1016/j.ajem.2022.11.015
Aktemur, M. R., et al. (2025). Comparative evaluation of HEART, T-MACS, and HE-MACS scores for risk stratification and management of patients with chest pain in the emergency department. Medicine, 104(6), Article e41432. https://doi.org/10.1097/MD.0000000000041432 DOI: https://doi.org/10.1097/MD.0000000000041432
Al-Zaiti, S. S., et al. (2023). Machine learning for ECG diagnosis and risk stratification of occlusion myocardial infarction. Nature Medicine, 29, 1804–1813. https://doi.org/10.1038/s41591-023-02396-3 DOI: https://doi.org/10.1038/s41591-023-02396-3
Ashburn, N. P., et al. (2023). Performance of the European Society of Cardiology 0/1-hour algorithm with high-sensitivity cardiac troponin T among patients with known coronary artery disease. JAMA Cardiology, 8(4), 347–356. https://doi.org/10.1001/jamacardio.2023.0031 DOI: https://doi.org/10.1001/jamacardio.2023.0031
Ataş, I., et al. (2025). Comparison of pretreatment in European Society of Cardiology acute coronary syndrome guidelines. Western Journal of Emergency Medicine, 26(6), 1679–1687. https://doi.org/10.5811/westjem.43528 DOI: https://doi.org/10.5811/WESTJEM.43528
Bergmark, B. A., et al. (2022). Acute coronary syndromes. The Lancet, 399(10332), 1347–1358. https://doi.org/10.1016/S0140-6736(21)02391-6 DOI: https://doi.org/10.1016/S0140-6736(21)02391-6
Bhatt, D. L., Lopes, R. D., & Harrington, R. A. (2022). Diagnosis and treatment of acute coronary syndromes: A review. JAMA, 327(7), 662–675. https://doi.org/10.1001/jama.2022.0358 DOI: https://doi.org/10.1001/jama.2022.0358
Biscaglia, S., et al. (2023). Complete or culprit-only PCI in older patients with myocardial infarction. New England Journal of Medicine, 389(10), 889–898. https://doi.org/10.1056/NEJMoa2300468 DOI: https://doi.org/10.1056/NEJMoa2300468
Byrne, R. A., et al. (2023). 2023 ESC Guidelines for the management of acute coronary syndromes. European Heart Journal, 44(38), 3720–3826. https://doi.org/10.1093/eurheartj/ehad191 DOI: https://doi.org/10.1093/eurheartj/ehad191
Cavalier, J. S., et al. (2025). Stress cardiovascular magnetic resonance imaging in intermediate-risk emergency department patients with abnormal high-sensitivity troponin. Journal of Cardiovascular Magnetic Resonance, 27, Article 101851. https://doi.org/10.1016/j.jocmr.2025.101851 DOI: https://doi.org/10.1016/j.jocmr.2025.101851
Cesar, L. A. M., et al. (2025). Diretriz de síndrome coronariana crônica – 2025. Arquivos Brasileiros de Cardiologia, 122(9), Article e20250619. https://doi.org/10.36660/abc.20250619 DOI: https://doi.org/10.36660/abc.20250619
De Barros e Silva, P. G. M., et al. (2025). Diretriz brasileira de atendimento à dor torácica na unidade de emergência – 2025. Arquivos Brasileiros de Cardiologia, 122(9), Article e20250620. https://doi.org/10.36660/abc.20250620 DOI: https://doi.org/10.36660/abc.20250620
Diletti, R., et al. (2023). Immediate versus staged complete revascularization in patients presenting with acute coronary syndrome and multivessel disease (BIOVASC): A prospective, open-label, non-inferiority, randomized trial. The Lancet, 401(10383), 1172–1182. https://doi.org/10.1016/S0140-6736(23)00351-3 DOI: https://doi.org/10.1016/S0140-6736(23)00351-3
Doudesis, D., et al. (2023). Machine learning for diagnosis of myocardial infarction using cardiac troponin concentrations. Nature Medicine, 29, 1201–1210. https://doi.org/10.1038/s41591-023-02325-4 DOI: https://doi.org/10.1038/s41591-023-02325-4
Engström, A., Mokhtari, A., & Ekelund, U. (2024). Direct comparison of the European Society of Cardiology 0/1-hour vs. 0/2-hour algorithms in patients with acute chest pain. Journal of Emergency Medicine, 66(6), e651–e659. https://doi.org/10.1016/j.jemermed.2024.02.004 DOI: https://doi.org/10.1016/j.jemermed.2024.02.004
Gulati, M., et al. (2021). 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the evaluation and diagnosis of chest pain: A report of the American College of Cardiology/American Heart Association joint committee on clinical practice guidelines. Circulation, 144(22), e368–e454. https://doi.org/10.1161/CIR.0000000000001029 DOI: https://doi.org/10.1161/CIR.0000000000001047
Kraler, S., et al. (2025). Acute coronary syndromes: Mechanisms, challenges, and new opportunities. European Heart Journal, 46(29), 2866–2889. https://doi.org/10.1093/eurheartj/ehaf289 DOI: https://doi.org/10.1093/eurheartj/ehaf289
Lambrou, K., et al. (2023). Impacts of high sensitivity troponin T reporting on care and outcomes in clinical practice: Interactions between low troponin concentrations and participant sex within two randomized clinical trials. International Journal of Cardiology, 393, Article 131396. https://doi.org/10.1016/j.ijcard.2023.131396 DOI: https://doi.org/10.1016/j.ijcard.2023.131396
Lima Filho, M. O., et al. (2024). Estratégia invasiva na síndrome coronária aguda sem supradesnível do segmento ST. Revista da Sociedade de Cardiologia do Estado de São Paulo, 34(2), 254–261. https://doi.org/10.29381/0103-8559/20243403254-61 DOI: https://doi.org/10.29381/0103-8559/20243403254-61
Møller, J. E., et al. (2024). Microaxial flow pump or standard care in infarct-related cardiogenic shock. New England Journal of Medicine, 390(15), 1382–1393. https://doi.org/10.1056/NEJMoa2312572 DOI: https://doi.org/10.1056/NEJMoa2312572
Rao, S. V., et al. (2025). 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the management of patients with acute coronary syndromes. Journal of the American College of Cardiology, 85(22), 2135–2237. https://doi.org/10.1016/j.jacc.2024.11.009 DOI: https://doi.org/10.1016/j.jacc.2024.11.009
Reynolds, H. R., et al. (2021). Coronary optical coherence tomography and cardiac magnetic resonance imaging to determine underlying causes of myocardial infarction with nonobstructive coronary arteries in women. Circulation, 143(7), 624–640. https://doi.org/10.1161/CIRCULATIONAHA.120.052008 DOI: https://doi.org/10.1161/CIRCULATIONAHA.121.055516
Sandoval, Y., et al. (2022). High-sensitivity cardiac troponin and the 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR guidelines for the evaluation and diagnosis of acute chest pain. Circulation, 146(7), 569–581. https://doi.org/10.1161/CIRCULATIONAHA.122.059678 DOI: https://doi.org/10.1161/CIRCULATIONAHA.122.059678
Stone, G. W., et al. (2024). Intravascular imaging-guided coronary drug-eluting stent implantation: An updated network meta-analysis. The Lancet, 403(10429), 824–837. https://doi.org/10.1016/S0140-6736(23)02454-6 DOI: https://doi.org/10.1016/S0140-6736(23)02454-6
Thiele, H., et al. (2023). Extracorporeal life support in infarct-related cardiogenic shock. New England Journal of Medicine, 389(14), 1286–1297. https://doi.org/10.1056/NEJMoa2307227 DOI: https://doi.org/10.1056/NEJMoa2307227
Todd, F., Duff, J., & Carlton, E. (2022). Identifying low-risk chest pain in the emergency department without troponin testing: A validation study of the HE-MACS and HEAR risk scores. Emergency Medicine Journal, 39, 515–518. https://doi.org/10.1136/emermed-2021-211669 DOI: https://doi.org/10.1136/emermed-2021-211669
Wenzl, F. A., et al. (2022). Sex-specific evaluation and redevelopment of the GRACE score in non-ST-segment elevation acute coronary syndromes in populations from the UK and Switzerland: A multinational analysis with external cohort validation. The Lancet, 400(10354), 744–756. https://doi.org/10.1016/S0140-6736(22)01483-0 DOI: https://doi.org/10.1016/S0140-6736(22)01483-0
Zou, Y., et al. (2021). Sex-differences in the management and clinical outcome among patients with acute coronary syndrome. BMC Cardiovascular Disorders, 21, Article 609. https://doi.org/10.1186/s12872-021-02433-4 DOI: https://doi.org/10.1186/s12872-021-02433-4