IN SILICO CHARACTERIZATION OF BRAIN-DERIVED NEUROTROPIC FACTOR
DOI:
https://doi.org/10.56238/levv16n53-057Keywords:
Brain-derived Neurotropic Factor, Neurology, Health, MedicineAbstract
BDNF acts as a modulator of synaptic plasticity, influencing both the central and peripheral nervous systems, in addition to regulating neurotransmitters and neuronal excitability. The main objective of this work is to evaluate the in silico characterization of Brain-Derived Neurotrophic Factor (BDNF) for structural, functional and molecular interactions analyses, to understand its role in neurobiological processes, neurodegenerative and psychiatric diseases. And as specific: to analyze the three-dimensional structure of BDNF; to study the molecular interactions between BDNF and its receptors (mainly TrkB); to identify potential mutations or variants that may affect BDNF function; to explore the relationship between BDNF and neurodegenerative diseases; to evaluate the viability of BDNF modulators as possible therapeutic targets. The theme “IN SILICO CHARACTERIZATION OF BRAIN-DERIVED NEUROTROPIC FACTOR: an integrative review” determined the construction of the PICO strategy, which represents an acronym for Patient (P), Intervention (I), Comparison (C) and Outcomes (O-outcomes), which generated the guiding question of this integrative literature review: “How can the in silico characterization of Brain-Derived Neurotrophic Factor (BDNF) contribute to the understanding of its structure, function and molecular interactions, as well as its implications in the development of neurodegenerative and psychiatric diseases, and in the direction of potential therapies?”. Some therapeutic strategies to increase BDNF are aerobic physical exercises and resistance training that increase BDNF, a diet rich in flavonoids (e.g.: blueberries, green tea) and omega-3 can modulate the expression of BDNF, TrkB agonists and gene therapy are promising, but still in clinical studies and deep brain stimulation (DBS) can restore neuronal plasticity via BDNF. There is a great need for more studies in the area, few articles were observed in the area and mainly in Brazil, on the subject.
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