THERAPEUTIC MANAGEMENT OF TAKOTSUBO CARDIOMYOPATHY: BROKEN HEART SYNDROME
DOI:
https://doi.org/10.56238/levv17n57-012Keywords:
Takotsubo Cardiomyopathy, Stress-Induced Cardiomyopathy, Acute Heart Failure, Left Ventricular Dysfunction, Clinical ManagementAbstract
Takotsubo cardiomyopathy, also known as broken heart syndrome or stress-related cardiomyopathy, is an acute and usually reversible cardiac condition characterized by transient left ventricular dysfunction without significant coronary obstruction. Its clinical presentation can be indistinguishable from acute myocardial infarction, including chest pain, electrocardiographic changes, and elevated cardiac markers. Although initially considered benign, recent evidence demonstrates a significant risk of complications such as arrhythmias, cardiogenic shock, and recurrence, as well as morbidity and mortality rates comparable to those of acute coronary syndrome. Prevalence is higher in postmenopausal women, but cases are also described in other contexts, such as the peripartum period, reinforcing the need for differential diagnosis and appropriate clinical follow-up. This study consisted of a narrative, qualitative, descriptive, and retrospective literature review conducted in the PubMed database between 2021 and 2025, using the descriptors "Takotsubo cardiomyopathy," "Management," and "Diagnosis." Full articles in Portuguese and English were included, excluding duplicates and studies with methodological weaknesses. It is concluded that Takotsubo cardiomyopathy requires an individualized therapeutic approach, early recognition, and multidisciplinary clinical follow-up, considering the risk of recurrence and psychosocial impacts
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References
ASSAD, J. et al. Takotsubo Syndrome: A Review of Presentation, Diagnosis and Management. Clinical Medicine Insights: Cardiology, v. 16, p. 1-11, 2022. DOI: https://doi.org/10.1177/11795468211065782
CITIOLO, Beatrice et al. Long-term prognosis and recurrence of Takotsubo Syndrome. Journal of Clinical Medicine, [s. l.], v. 12, n. 4, p. 1540-1555, 2023.
DAVE, P. et al. Ultrasound Used in the Diagnosis of Reverse Takotsubo Cardiomyopathy. Clinical Practice and Cases in Emergency Medicine, v. 8, n. 4, p. 384-385, 2024. DOI: https://doi.org/10.5811/CPCEM.20811
FONTELLES MJ, SIMÕES MG, FARIAS SH, FONTELLES RGS. Metodologia da pesquisa científica: diretrizes para elaboração de um protocolo de pesquisa. Rev. para. med; 23(3) jul-set 2009. ID: lil-588477.
HE, Li et al. Speckle tracking echocardiography in the diagnosis and risk stratification of Takotsubo Syndrome: a 2021-2024 update. Echocardiography, [s. l.], v. 41, n. 1, p. 115-128, 2024.
MATTA, A. et al. Takotsubo cardiomyopathy. Reviews in Cardiovascular Medicine, v. 23, n. 1, p. 038, 2022. DOI: https://doi.org/10.31083/j.rcm2301038
MATTA, A. G.; CARRIÉ, D. Epidemiology, Pathophysiology, Diagnosis, and Principles of Management of Takotsubo Cardiomyopathy: A Review. Medical Science Monitor, v. 29, p. e939020, 2023. DOI: https://doi.org/10.12659/MSM.939020
MURPHY, C. et al. Peripartum takotsubo cardiomyopathy after an emergency Caesarean delivery-diagnosis and specialist management. BJA Open, v. 15, p. 100478, 2025. DOI: https://doi.org/10.1016/j.bjao.2025.100478
PILLITTERI, M. et al. Perioperative management of Takotsubo cardiomyopathy: an overview. Journal of Anesthesia, Analgesia and Critical Care, v. 4, n. 45, 2024. DOI: https://doi.org/10.1186/s44158-024-00178-y
SANTORO, Francesco et al. The role of biomarkers in Takotsubo Syndrome: A comprehensive review. International Journal of Cardiology, [s. l.], v. 343, p. 1-12, 2022.
SINGH, T. et al. Takotsubo Syndrome: Pathophysiology, Emerging Concepts and Clinical Implications. Circulation, v. 145, n. 13, p. 1002-1019, 2022. DOI: https://doi.org/10.1161/CIRCULATIONAHA.121.055854