CENTRAL PRECOCIOUS PUBERTY, CLINICAL MANIFESTATIONS, AND CURRENT MANAGEMENT: A SYSTEMATIC REVIEW

Abstract

Objective: The general objective of the present study is to analyze the scientific production on Central Precocious Puberty, seeking to identify the main mechanisms involved in the etiopathogenesis, as well as the main methods used in the treatment of this pathology. Methodology: It is a systematic review focused on understanding the main aspects of Central Precocious Puberty. The research was guided by the question: "What are the main etiopathogenic mechanisms involved in the development of central precocious puberty, as well as the signs and symptoms and their management today?". To find answers, searches were performed in the PubMed database using four descriptors combined with the Boolean term "AND": Precocious Puberty; Pubertal Delay; Hormonal Treatment and Diagnosis. This resulted in 122 articles. 18 articles were selected for analysis Results: Puberty is a crucial phase that impacts the physical, emotional and social development of the child. Precocious puberty can be central (PPC) or peripheral (PPP), each with its own characteristics. Genetic mutations in genes such as KISS1, KISS1R, and MKRN3 help to understand their causes. Tumors and lesions of the central nervous system can contribute to SSC, highlighting the importance of a thorough clinical evaluation. Treatment with GnRH analogues is essential to control the premature advancement of sexual signs and preserve final height. Conclusion: An informed and continuous approach is essential for effective management and to improve clinical outcomes.